2. MAPK/ERK Pathway
  3. JNK
  4. DN-1289

DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability.

For research use only. We do not sell to patients.

DN-1289 Chemical Structure

DN-1289 Chemical Structure

CAS No. : 3026597-15-6

Size Price Stock Quantity
5 mg USD 230 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
10 mg USD 370 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
25 mg USD 750 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
50 mg USD 1200 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
100 mg USD 1920 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
200 mg   Get quote  
500 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

DN-1289 Related Antibodies

Top Publications Citing Use of Products

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability[1].

IC50 & Target

IC50: 17 nM (DLK), 40 nM (LZK)[1]
In Vitro

DN-1289 (compound 14) (0.1, 0.3, and 1 μM; 0-20 h) can block axon degeneration in dorsal root ganglion (DRG) neurons induced by nerve growth factor (NGF) withdrawal[1].
DN-1289 (0.1, 0.3, and 1 μM; 0-20 h) inhibits the activation of caspases in DRG neurons over time induced by NGF withdrawal[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DN-1289 Related Antibodies
In Vivo

DN-1289 (compound 14) (100 mg/kg and 150 mg/kg; i.p.; once daily for 10-15 d) is well-tolerated in mice model[1].
DN-1289 (150 mg/kg; p.o.; b.i.d. for 10 d) inhibits phosphorylation of c-Jun in an acute injury model with optic nerve crush (ONC) application[1].

Pharmacokinetic Analysis[1]

Species Route Dose (mg/kg) plasma Cmax (μM) plasma AUC0-24 h (μM·h) CLp (mL/min/kg) CLu (mL/min/kg) Vd (L/kg) t1/2 (h) F (%) Kpuu (AUC) brain AUC0-2 h (μM·h)
rat IV 1 1.09 2.42 14.7 150 6.7 6.5 / 0.6 4.05
PO 3 0.58 3.9 / / / 4.6 52 / /
mouse IV 1 1.06 4.06 8.6 200 4.7 6.8 / / /
PO 10 2.32 21.9 / / / 7.9 56 0.4 6.91
PO 150 24.9 324 / / / 23.7 53 / /
IP 100 15.4 280 / / / 23.7 53 / /
cyno IV 0.5 0.746 2.79 6.1 64 3.4 7.9 / / /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

441.38

Formula

C18H19F4N7O2
CAS No.
SMILES

NC1=C(OC(F)F)N=C(C2=NC(N3[C@@H](C4)CO[C@@H]4C3)=NC(N5CCC(F)(F)C5)=C2)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

DN-1289 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DN-12893026597-15-6DN1289DN 1289JNKc-Jun N-terminal kinaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DN-1289
Cat. No.:
HY-152142
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.