2. MAPK/ERK Pathway
  3. MAP3K
  4. GNE-8505

GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).

For research use only. We do not sell to patients.

GNE-8505 Chemical Structure

GNE-8505 Chemical Structure

CAS No. : 1620573-48-9

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1 mg USD 100 In-stock
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

GNE-8505 Related Antibodies

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MAP3K7/TAK1 MAP3K8 ASK2 MAP3K5/ASK1

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Description

GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK)[1].

IC50 & Target

DLK[1]
Molecular Weight

419.44

Formula

C21H24F3N5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)C1=CC(C2=NN(C([C@@H]3[C@]4([H])[C@@]3([H])CN(C5COC5)C4)=C2)CC6CC6)=CN=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (238.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3841 mL 11.9207 mL 23.8413 mL
5 mM 0.4768 mL 2.3841 mL 4.7683 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3841 mL 11.9207 mL 23.8413 mL 59.6033 mL
5 mM 0.4768 mL 2.3841 mL 4.7683 mL 11.9207 mL
10 mM 0.2384 mL 1.1921 mL 2.3841 mL 5.9603 mL
15 mM 0.1589 mL 0.7947 mL 1.5894 mL 3.9736 mL
20 mM 0.1192 mL 0.5960 mL 1.1921 mL 2.9802 mL
25 mM 0.0954 mL 0.4768 mL 0.9537 mL 2.3841 mL
30 mM 0.0795 mL 0.3974 mL 0.7947 mL 1.9868 mL
40 mM 0.0596 mL 0.2980 mL 0.5960 mL 1.4901 mL
50 mM 0.0477 mL 0.2384 mL 0.4768 mL 1.1921 mL
60 mM 0.0397 mL 0.1987 mL 0.3974 mL 0.9934 mL
80 mM 0.0298 mL 0.1490 mL 0.2980 mL 0.7450 mL
100 mM 0.0238 mL 0.1192 mL 0.2384 mL 0.5960 mL
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GNE-8505 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GNE-85051620573-48-9GNE8505GNE 8505MAP3KMAP kinase kinase kinase, MEKK, MAPKKKInhibitorinhibitorinhibit

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