2. MAPK/ERK Pathway
  3. JNK
  4. GDC-0134

GDC-0134 is a potent, selective, orally active, brain-penetrant dual leucine zipper kinase (DLK) inhibitor. GDC-0134 blocks DLK activity in cellular assays and in animal models of neuronal injury. GDC-0134 can be used for the study of amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

GDC-0134 Chemical Structure

GDC-0134 Chemical Structure

CAS No. : 1637394-01-4

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Based on 1 publication(s) in Google Scholar

GDC-0134 Related Antibodies

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Description

GDC-0134 is a potent, selective, orally active, brain-penetrant dual leucine zipper kinase (DLK) inhibitor. GDC-0134 blocks DLK activity in cellular assays and in animal models of neuronal injury. GDC-0134 can be used for the study of amyotrophic lateral sclerosis (ALS)[1].

Molecular Weight

440.39

Formula

C19H20F4N6O2
CAS No.
Appearance

Solid

SMILES

NC1=C(C=C(C=N1)C2=NC(N3CC(F)(CC3)F)=NC(N4C[C@H]5OC[C@@H]4C5)=C2)OC(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (227.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2707 mL 11.3536 mL 22.7071 mL
5 mM 0.4541 mL 2.2707 mL 4.5414 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2707 mL 11.3536 mL 22.7071 mL 56.7679 mL
5 mM 0.4541 mL 2.2707 mL 4.5414 mL 11.3536 mL
10 mM 0.2271 mL 1.1354 mL 2.2707 mL 5.6768 mL
15 mM 0.1514 mL 0.7569 mL 1.5138 mL 3.7845 mL
20 mM 0.1135 mL 0.5677 mL 1.1354 mL 2.8384 mL
25 mM 0.0908 mL 0.4541 mL 0.9083 mL 2.2707 mL
30 mM 0.0757 mL 0.3785 mL 0.7569 mL 1.8923 mL
40 mM 0.0568 mL 0.2838 mL 0.5677 mL 1.4192 mL
50 mM 0.0454 mL 0.2271 mL 0.4541 mL 1.1354 mL
60 mM 0.0378 mL 0.1892 mL 0.3785 mL 0.9461 mL
80 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7096 mL
100 mM 0.0227 mL 0.1135 mL 0.2271 mL 0.5677 mL
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GDC-0134 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GDC-01341637394-01-4GDC0134GDC 0134JNKc-Jun N-terminal kinaseDLK inhibitorbrain-penetrantorally activeamyotrophic lateral sclerosis (ALS)Inhibitorinhibitorinhibit

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