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Isoforms Recommended:	DNMT1

Results for "

DNMT1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Apoptosis (5) Autophagy (3) Deubiquitinase (1) DNA Methyltransferase (19) E1/E2/E3 Enzyme (1) HDAC (1) Histone Methyltransferase (4) Keap1-Nrf2 (1) Nucleoside Antimetabolite/Analog (1) Potassium Channel (3) Small Interfering RNA (siRNA) (3) Virus Protease (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

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Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123346

SW155246	DNA Methyltransferase	Cancer
SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC₅₀s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases ^[1].

HY-135146

GSK-3484862 10+ Cited Publications	DNA Methyltransferase	Cancer
GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity ^[1] .

HY-15228

RX-3117 1 Publications Verification TV-1360; Fluorocyclopentenylcytosine	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis ^[1] .

HY-150249

GSK3735967 1 Publications Verification	DNA Methyltransferase	Cancer
GSK3735967 is an selective, reversible, non-nucleoside inhibitor of *DNMT1* with an IC₅₀ value of 40 nM. GSK3735967 contains a planar dicyanopyridine core that can specifically embed DNMT1 bound hemimethylated CpG dinucleotides. GSK3735967 has three binding sites, one of which can bind to histone H4K20me3 ^[1] .

HY-RS03908

DNMT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DNMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for DNMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DNMT1 Human Pre-designed siRNA Set A DNMT1 Human Pre-designed siRNA Set A

HY-RS03909

Dnmt1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dnmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dnmt1 Mouse Pre-designed siRNA Set A Dnmt1 Mouse Pre-designed siRNA Set A

HY-RS03910

Dnmt1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dnmt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dnmt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dnmt1 Rat Pre-designed siRNA Set A Dnmt1 Rat Pre-designed siRNA Set A

HY-119054

DNMT1-IN-4	DNA Methyltransferase	Cancer
DNMT1-IN-4 is a potent non-nucleoside DNA methyltransferase 1 (DNMT1) inhibitor with an IC₅₀ value of 2.5 µM and selectivity towards other AdoMet-dependent protein methyltransferases. DNMT1-IN-4 significantly inhibits cancer cell proliferation ^[1].

HY-161694

DNMT1-IN-3	DNA Methyltransferase	Cancer
DNMT1-IN-3 (compound 7t-S) is an effective DNA methyltransferase 1 (DNMT1) inhibitor with an IC₅₀ value of 0.777 μM and a K_D value of 0.183 μM. DNMT1-IN-3 can bind to the methyl donor S-adenosyl-l-methionine (SAM) site in DNMT1. DNMT1-IN-3 can inhibit cell proliferation in K562 cells by inducing cells apoptosis and arresting cell cycle at G0 / G1 phase, which has the potential to be used for the research of hematologic tumor ^[1].

HY-168088

DNMT1/HDAC-IN-1	HDAC DNA Methyltransferase	Cancer
DNMT1/HDAC-IN-1 (compound (R)-23a) is a *DNMT1/HDAC* dual inhibitor (HDAC1:IC₅₀=0.05 μM), *HDAC1* is a major HDAC isoform that interacts with *DNMT1* in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities ^[1].

HY-103236

NSC232003 2 Publications Verification	E1/E2/E3 Enzyme	Cancer
NSC232003 is a highly potent and cell-permeable *UHRF1* inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.

HY-12746

DC-05 1 Publications Verification	DNA Methyltransferase	Cancer
DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 10.3 μM and 1.09 μM, respectively.

HY-12747

DC_517 2 Publications Verification	DNA Methyltransferase	Cancer
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 1.7 μM and 0.91 μM, respectively.

HY-135146A

(Rac)-GSK-3484862	Others	Cancer
(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity ^[1] .

HY-A0084

Procainamide hydrochloride 4 Publications Verification Procaine amide hydrochloride; SP 100 hydrochloride	DNA Methyltransferase Potassium Channel	Cancer
Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research ^[1] .

HY-A0084A

Procainamide 4 Publications Verification Procaine amide; SP 100	DNA Methyltransferase Potassium Channel	Cardiovascular Disease Cancer
Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research ^[1] .

HY-139664

GSK-3685032 5 Publications Verification	DNA Methyltransferase	Cancer
GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1].

HY-B2230

Hinokitiol 5 Publications Verification β-Thujaplicin	Keap1-Nrf2 DNA Methyltransferase Virus Protease	Infection Cancer
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases *DNMT1* and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-13962

SGI-1027 5+ Cited Publications	DNA Methyltransferase Apoptosis	Cancer
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC₅₀s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.

HY-15647

BRD9539 1 Publications Verification	Histone Methyltransferase	Cancer
BRD9539 is a histone methyltransferase G9a inhibitor with an IC₅₀ of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1 ^[1].

HY-101925

CM-272 3 Publications Verification	Histone Methyltransferase DNA Methyltransferase Apoptosis	Cancer
CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, *DNMT1, DNMT3A, DNMT3B* and GLP with IC₅₀s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death ^[1].

HY-139664A

(R)-GSK-3685032	DNA Methyltransferase	Cancer
(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1] .

HY-B2194

γ-Oryzanol 5+ Cited Publications	DNA Methyltransferase	Metabolic Disease Cancer
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of *DNMT1* (IC₅₀=3.2 μM), *DNMT3a* (IC₅₀=22.3 μM).

HY-146887

USP7-IN-9	Deubiquitinase Apoptosis	Cancer
USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC₅₀ value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and DNMT1 and increases the protein levels of tumor suppressors p53 and p21 ^[1].

HY-19826

Isofistularin-3	DNA Methyltransferase ADC Cytotoxin Autophagy Apoptosis	Cancer
Isofistularin-3 is a direct, DNA-competitive *DNMT1* inhibitor, with an IC₅₀ of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin ^[1].

HY-139664B

(S)-GSK-3685032	Others	Cancer
(S)-GSK-3685032 is the isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1].

HY-121093

DC-S239	Histone Methyltransferase	Cancer
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC₅₀ value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity ^[1].

HY-111544

EML741	Histone Methyltransferase	Cancer
EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC₅₀ of 23 nM, K_d of 1.13 μM for G9a. EML741 also inhibits DNMT1 (IC₅₀, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated ^[1].

HY-149389

PNMT-IN-1	Others	Endocrinology
PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a K_i value of 1.2 nM and a IC₅₀ value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC₅₀ value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor ^[1].

HY-139015

5-Aza-4'-thio-2'-deoxycytidine 5-Aza-T-dCyd; NTX-301	DNA Methyltransferase	Cancer
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects ^[1].

HY-A0084R

Procainamide hydrochloride (Standard)	DNA Methyltransferase Potassium Channel	Cancer
Procainamide (hydrochloride) (Standard) is the analytical standard of Procainamide (hydrochloride). This product is intended for research and analytical applications.

HY-17389

Genipin Maximum Cited Publications 12 Publications Verification (+)-Genipin	Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

HY-17389R

Genipin (Standard)	Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

Hinokitiol 5 Publications Verification β-Thujaplicin	Infection Structural Classification Cupressaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Chamaecyparis obtusa	Keap1-Nrf2 DNA Methyltransferase Virus Protease
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases *DNMT1* and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

γ-Oryzanol 5+ Cited Publications	Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Steroids Cancer	DNA Methyltransferase
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of *DNMT1* (IC₅₀=3.2 μM), *DNMT3a* (IC₅₀=22.3 μM).

Genipin Maximum Cited Publications 12 Publications Verification (+)-Genipin	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Iridoids Terpenoids Rubiaceae Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	Autophagy
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

Genipin (Standard)	Structural Classification Human Gut Microbiota Metabolites Iridoids Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Endogenous metabolite	Autophagy
Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

Species:	Human (2)
Tag:	Tag Free (1) GST (1) Flag (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P703564

	DNMT1 Protein, Human AIM; CXXC9; DNMT	Human	E. coli
	DNMT1 Protein, Human is the recombinant human-derived DNMT1, expressed by E. coli , with tag Free labeled tag. The total length of DNMT1 Protein, Human is 1250 a.a.,

HY-P703565

	DNMT1 Protein, Human (Sf9, GST, Flag) AIM; CXXC9; DNMT	Human	Sf9 insect cells
	DNMT1 Protein, Human (Sf9, GST, Flag) is the recombinant human-derived DNMT1, expressed by Sf9 insect cells , with GST, Flag labeled tag. The total length of DNMT1 Protein, Human (Sf9, GST, Flag) is 1616 a.a.,

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HY-P80105

	DNMT1 Antibody (YA781)	WB, IHC-P, FC	Human
	DNMT1 Antibody (YA781) is a non-conjugated and Mouse origined monoclonal antibody about 183 kDa, targeting to DNMT1. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human.

HY-P80106

	Dnmt1 Antibody (YA476)	WB, ICC/IF, IHC-P	Human, Mouse
	Dnmt1 Antibody (YA476) is a non-conjugated and Rabbit origined monoclonal antibody about 183 kDa, targeting to Dnmt1. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

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