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  4. (Rac)-GSK-3484862

(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity.

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(Rac)-GSK-3484862 Chemical Structure

(Rac)-GSK-3484862 Chemical Structure

CAS No. : 2170136-02-2

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Based on 1 publication(s) in Google Scholar

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Description

(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity[1][2].

Molecular Weight

365.45

Formula

C19H19N5OS
CAS No.
Appearance

Solid

Color

Brown to orange

SMILES

O=C(N)C(SC1=NC(N(C)C)=C(C#N)C(CC)=C1C#N)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (54.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7364 mL 13.6818 mL 27.3635 mL
5 mM 0.5473 mL 2.7364 mL 5.4727 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7364 mL 13.6818 mL 27.3635 mL 68.4088 mL
5 mM 0.5473 mL 2.7364 mL 5.4727 mL 13.6818 mL
10 mM 0.2736 mL 1.3682 mL 2.7364 mL 6.8409 mL
15 mM 0.1824 mL 0.9121 mL 1.8242 mL 4.5606 mL
20 mM 0.1368 mL 0.6841 mL 1.3682 mL 3.4204 mL
25 mM 0.1095 mL 0.5473 mL 1.0945 mL 2.7364 mL
30 mM 0.0912 mL 0.4561 mL 0.9121 mL 2.2803 mL
40 mM 0.0684 mL 0.3420 mL 0.6841 mL 1.7102 mL
50 mM 0.0547 mL 0.2736 mL 0.5473 mL 1.3682 mL
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(Rac)-GSK-3484862 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-GSK-34848622170136-02-2OthersDNAmethyltransferase1Dnmt1hypomethylationepigenetictherapies5-AzacytidineInhibitorinhibitorinhibit

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