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GDC-2992

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156751A
    GDC-2992

    RO7656594

    		 PROTACs Androgen Receptor Cancer
    GDC-2992 (Compound 28A) is an orally active degrader of androgen receptor (AR). GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. GDC-2992 can be used for prostatic cancer study. (Structure Note: Pink: target protein ligand (HY-130845); Blue: E3 ligase ligand (HY-W1003189A); Black: linker (HY-169975); E3 ligase ligand +linker (HY-169976A)) .
    GDC-2992
  • HY-156751
    (Rac)-GDC-2992

    (Rac)-RO7656594; PROTAC AR Degrader-6

    		 PROTACs Androgen Receptor Cancer
    (Rac)-GDC-2992 (Compound 1) is a PROTAC androgen receptor degrader (DC50: 10 nM in VCaP cell). (Rac)-GDC-2992 blocks the process of androgen receptor transduction and also degrades the receptor itself. (Rac)-GDC-2992 can be used for prostate cancer research. Pink: AR ligand (HY-130845); Blue: E3 ligase ligand (HY-W1003189); Black: linker (HY-169975) .
    (Rac)-GDC-2992

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