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GSK_WRN3

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162471
    GSK_WRN3

    		DNA/RNA Synthesis Cancer
    GSK_WRN3 is a selective inhibitor of WRN protease (pIC50 = 8.6). GSK_WRN3 displays a high degree of selectivity by forming a covalent binding to the Cys727 residue of the WRN protein. GSK_WRN3 reduces growth support for MSI tumor cells by inhibiting WRN protease activity, resulting in increased DNA double-strand breaks and cell growth inhibition .
    GSK_WRN3

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