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HPV16 E7 (86-93) TFA is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) TFA is immunogenic in cervical carcinomas .
Retro-2 cycl (RN 1-001) is a dihydroquinazolinone (DHQZ) inhibitor of retrograde trafficking. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus with IC50s of 54 μM and 160 μM, respectively . Antiviral agent .
A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM . A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16(HPV16) infection .
A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM . A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16(HPV16) infection .
GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by
EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes .
HPV16-E711-20 epitope is a well-known HLA-A *0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein that shows high-affinity binding to HLA-A2 in vitro. HPV16 CTL epitopes may be good candidates for the development of an effective peptide-based antitumor vaccine .
Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity .
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture .
E6-272 is an inhibitor for human papillomavirus 16(HPV 16). E6-272 inhibits the proliferation of HPV-positive cells SiHa and CaSki with GI50 of 32 nM and 62 nM. E6-272 induces apoptosis in cell SiHa and CaSki .
HPV16 E7 (86-93) TFA is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) TFA is immunogenic in cervical carcinomas .
HPV16-E711-20 epitope is a well-known HLA-A *0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein that shows high-affinity binding to HLA-A2 in vitro. HPV16 CTL epitopes may be good candidates for the development of an effective peptide-based antitumor vaccine .
LyP-2 is a peptide that homes to tumor lymphatics. LyP2 homes to lymphatics of C8161 melanomas and cervical carcinomas and K14-HPV16 skin, but not to MDA-MB435 tumors, showing heterogeneity in the molecular markers of tumor cells and lymphatics .
Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity .
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture .
B2M is a component of MHC class I complexes that present peptide antigens to the immune system. HLA-A*0201 HPV16 E7 complex Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived HLA-A*0201 HPV16 E7 complex protein, expressed by HEK293 , with C-10*His labeled tag. HLA-A*0201 HPV16 E7 complex Protein, Human (HEK293, His), has molecular weight of 55-60 kDa.
HPV protein E7 can induce dormant cells to enter the cell cycle and promote the efficient use of cellular DNA replication mechanisms for viral genome replication. Through translational and transactivation activities, E7 disrupts the RB1-E2F1 complex and activates E2F1-regulated S-phase genes. Protein E7, HPV16 (His) is the recombinant Virus-derived protein E7, HPV, expressed by E. coli , with N-6*His labeled tag.
The TRIP13 protein plays a key role in meiosis, affecting chromosome reorganization and structural development. It is critical for the formation of crossing and noncrossing pathways, homologous synapses, and synaptonemal complexes. TRIP13 Protein, Human (His, Strep) is the recombinant human-derived TRIP13 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of TRIP13 Protein, Human (His, Strep) is 432 a.a., .
The TRIP13 protein plays a key role in meiosis, affecting chromosome reorganization and structural development. It is critical for the formation of crossing and noncrossing pathways, homologous synapses, and synaptonemal complexes. TRIP13 Protein, Human is the recombinant human-derived TRIP13 protein, expressed by E. coli , with tag free. The total length of TRIP13 Protein, Human is 432 a.a., .
HLA-A*0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A*0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A*0201 HPV16 E6 Complex Protein, Human (KLPQLCTEL, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A*0201 HPV16 E6 Complex protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A*0201 HPV16 E6 Complex Protein, Human (KLPQLCTEL, HEK293, His-Avi), has molecular weight of 53-63 kDa.
The HLA-A*0201 HPV16 E7 complex, part of the MHCI family, is central to immune recognition. Associated with β2 microglobulin, it presents viral and tumor peptides on antigen-presenting cells for CD8-positive T cell recognition. This interaction guides antigen-specific T cell responses against infected or transformed cells. The complex's diverse repertoire includes self-peptides and varies in peptide length, contributing to antigen specificity. HLA-A*0201, representing this complex, presents viral and tumor-associated epitopes, highlighting its pivotal role in immune responses against pathogens and cancer. HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-A*0201 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and YMLDLQPET peptide. HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His-Avi), has molecular weight of 53-63 kDa.
HLA-A*0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A*0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A*0201 HPV16 E6 Complex Tetramer Protein, Human (KLPQLCTEL, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A*0201 HPV16 E6 Complex Tetramer protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A*0201 HPV16 E6 Complex Tetramer Protein, Human (KLPQLCTEL, HEK293, His-Avi), has molecular weight of 260-265 kDa.
The HLA-A*0201 HPV16 E7 complex, part of the MHCI family, is central to immune recognition. Associated with β2 microglobulin, it presents viral and tumor peptides on antigen-presenting cells for CD8-positive T cell recognition. This interaction guides antigen-specific T cell responses against infected or transformed cells. The complex's diverse repertoire includes self-peptides and varies in peptide length, contributing to antigen specificity. HLA-A*0201, representing this complex, presents viral and tumor-associated epitopes, highlighting its pivotal role in immune responses against pathogens and cancer. HLA-A*0201 HPV16 E7 complex Protein, Human (Biotinylated, YMLDLQPET, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-A*0201 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and YMLDLQPET peptide. HLA-A*0201 HPV16 E7 complex Protein, Human (Biotinylated, YMLDLQPET, HEK293, His-Avi), has molecular weight of 53-63 kDa.
The HLA-A*0201 HPV16 E7 complex, part of the MHCI family, is central to immune recognition. Associated with β2 microglobulin, it presents viral and tumor peptides on antigen-presenting cells for CD8-positive T cell recognition. This interaction guides antigen-specific T cell responses against infected or transformed cells. The complex's diverse repertoire includes self-peptides and varies in peptide length, contributing to antigen specificity. HLA-A*0201, representing this complex, presents viral and tumor-associated epitopes, highlighting its pivotal role in immune responses against pathogens and cancer. HLA-A*0201 HPV16 E7 complex Tetramer Protein, Human (YMLDLQPET, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-A*0201 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and YMLDLQPET peptide. HLA-A*0201 HPV16 E7 complex Tetramer Protein, Human (YMLDLQPET, HEK293, His-Avi), has molecular weight of 260-265 kDa.
Protein E6 is one of three cancer proteins encoded by human papillomavirus (HPV). The binding of Protein E6 to ubiquitin protein ligase can inhibit the expression of p53. Protein E6 suppresses the immune response through the JAK-STAT signaling pathway. Protein E6 can promote cell proliferation and inhibit cell apoptosis. Protein E6, HPV16 (His) is the recombinant Virus-derived protein E6, HPV16, expressed by E. coli , with N-6*His labeled tag.
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