2. Anti-infection
  3. EBV HPV
  4. GSK983

GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes.

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GSK983 Chemical Structure

GSK983 Chemical Structure

CAS No. : 827591-02-6

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5 mg USD 435 In-stock
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Based on 1 publication(s) in Google Scholar

GSK983 Related Antibodies

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Description

GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes[1].

In Vitro

GSK983 (0-10000 nM; 2 h) inhibits replication of adenovirus-5 (Ad-5) in primary human fibroblasts (HFF) and polyoma virus SV40 in Vero cells with the median effect concentration (K) of 21 nM, 7.5 nM; and maximum inhibition (I max) of 99%, 88%, respectively[1].
GSK983 (0-10000 nM; 72 h) inhibits the growth of cell lines immortalized by viral infection with the median effect concentration (K) of 16, 14, 7.5 nM for IM9 (EBV), B-LCL 5/2/1 (EBV), MT4 (HTLV1) cells, respectively[1].
GSK983 (10, 100 nM; 24, 48 h) induces the expression of interferon-stimulated genes in W12, HKC cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK983 Related Antibodies

RT-PCR[1]

Cell Line: W12, HKC cells
Concentration: 10, 100 nM
Incubation Time: 24, 48 h
Result: Induced the expression of interferon-stimulated genes in infected and immortalized cells, increased the gene expression of CSF2, IFIT1 (ISG56), IL6, ISG15, OAS1, OAS2, OASL and TNFSF10 (TRAIL).
Molecular Weight

325.79

Formula

C18H16ClN3O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=NC=CC=C1)N[C@H]2C3=C(CCC2)C(C=C(C=C4)Cl)=C4N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10 mg/mL (30.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0695 mL 15.3473 mL 30.6946 mL
5 mM 0.6139 mL 3.0695 mL 6.1389 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.8%

SDS (393 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0695 mL 15.3473 mL 30.6946 mL 76.7365 mL
5 mM 0.6139 mL 3.0695 mL 6.1389 mL 15.3473 mL
10 mM 0.3069 mL 1.5347 mL 3.0695 mL 7.6737 mL
15 mM 0.2046 mL 1.0232 mL 2.0463 mL 5.1158 mL
20 mM 0.1535 mL 0.7674 mL 1.5347 mL 3.8368 mL
25 mM 0.1228 mL 0.6139 mL 1.2278 mL 3.0695 mL
30 mM 0.1023 mL 0.5116 mL 1.0232 mL 2.5579 mL
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GSK983 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK983827591-02-6GSK 983GSK-983EBVHPVEpstein-Barr VirusHuman papillomavirusadenovirus-5SV40HPV-16W12HKC cellsinterferon-stimulated genesInhibitorinhibitorinhibit

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