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Results for "

Hydroxyeicosatetraenoic

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

5

Peptides

1

Natural
Products

4

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15603
    TS-011

    		Orphan Receptor Cardiovascular Disease
    TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.
    TS-011
  • HY-101527
    20-HEDE
    2 Publications Verification

    WIT 002

    		 Cytochrome P450 Cancer
    20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE).
    20-HEDE
  • HY-160187
    AAA

    		Orphan Receptor Cardiovascular Disease
    AAA is a potent blocker of 20-Hydroxyeicosatetraenoic acid (20-HETE) receptor that binds directly to GPR75 and prevents the increases in intracellular Ca2+, IP-1 and β-arrestin .
    AAA
  • HY-B0174A
    Olsalazine

    		Leukotriene Receptor Antibiotic Inflammation/Immunology
    Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .
    Olsalazine
  • HY-124527
    HET0016
    2 Publications Verification

    		 Cytochrome P450 Cardiovascular Disease Cancer
    HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth .
    HET0016
  • HY-112653
    8(S)-HETE

    8(S)-Hydroxyeicosatetraenoic acid

    		 PPAR Inflammation/Immunology
    8(S)-HETE (8(S)-Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
    8(S)-HETE
  • HY-158843
    15(S)-Hete-biotin

    15(S)-Hydroxyeicosatetraenoic acid-biotin

    		 Endogenous Metabolite Others
    15(S)-Hete-biotin (15(S)-Hydroxyeicosatetraenoic acid-biotin) can be used to detect 15(S)-HETE binding proteins and/or receptors. 15(S)-HETE is an arachidonic acid metabolite produced by the 15-lipoxygenase pathway .
    15(S)-Hete-biotin
  • HY-113453A
    11-S-Hydroxyeicosatetraenoic acid

    11(S)-Hydroxy-5(Z),8(Z),12(E),14(Z)-eicosatetraenoic acid

    		 Biochemical Assay Reagents Metabolic Disease
    11-S-Hydroxyeicosatetraenoic acid (11(S)-Hydroxy-5(Z),8(Z),12(E),14(Z)-eicosatetraenoic acid) is an ester product.
    11-S-Hydroxyeicosatetraenoic acid
  • HY-115408
    9(R)-HETE

    9(R)-Hydroxyeicosatetraenoic acid

    		 Others Others
    9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.1 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
    9(R)-HETE
  • HY-120460
    8(R)-HETE

    8(R)-Hydroxyeicosatetraenoic acid

    		 Endogenous Metabolite Inflammation/Immunology
    8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
    8(R)-HETE
  • HY-B0174AS1
    Olsalazine-d3

    		Antibiotic Leukotriene Receptor Isotope-Labeled Compounds Inflammation/Immunology
    Olsalazine-d3 is deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .
    Olsalazine-d3
  • HY-108611
    AACOCF3
    3 Publications Verification

    Arachidonyl trifluoromethyl ketone

    		 Phospholipase Cardiovascular Disease
    AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
    AACOCF3
  • HY-B0174AS2
    Olsalazine-d3,15N

    		Antibiotic Leukotriene Receptor Isotope-Labeled Compounds Inflammation/Immunology
    Olsalazine-d3, 15N is 15N and deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .
    Olsalazine-d3,15N
  • HY-113443
    12(S)-HPETE

    		AP-1 Metabolic Disease
    12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .
    12(S)-HPETE
  • HY-101016
    17-ODYA

    		Cytochrome P450 Apoptosis Cardiovascular Disease
    17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC50<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes . 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    17-ODYA
  • HY-116050A
    17(R)-HETE

    		Cytochrome P450 Others
    17R-HETE is an arachidonic acid metabolite through cytochrome P-450 pathways. 17R-HETE exhibits efficacy in inducing cardic hypertrophy with less efficiency with compared to 17S-HETE .
    17(R)-HETE
  • HY-158104
    LPPM-8

    		ATF6 Others
    LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .
    LPPM-8
  • HY-P3100
    Orfamide A

    		Parasite Infection
    Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC50 value of 34.5 μg/mL .
    Orfamide A
  • HY-15598S
    20-HETE-d6

    20-Hydroxyarachidonic acid-d6; 20-Hydroxyeicosatetraenoic acid-d6

    		 Isotope-Labeled Compounds Others
    20-HETE-d6 is the deuterium labeled 20-HETE[1].
    20-HETE-d6
  • HY-120556
    tetranor-12(R)-HETE

    8(R)-HHxTrE; tetranor-12(R)-Hydroxyeicosatetraenoic acid; 2,3,4,5-Tetranor 12(R)-HETE

    		 Drug Metabolite Metabolic Disease
    tetranor-12(R)-HETE is a metabolite of 12(R)-HETE formed via β-oxidation.
    tetranor-12(R)-HETE
  • HY-113439
    12-HETE
    1 Publications Verification

    		 Apoptosis Cardiovascular Disease Inflammation/Immunology
    12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .
    12-HETE
  • HY-145473
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

    15(S)-HETE-SAPE; 15(S)-Hydroxyeicosatetraenoic acid-SAPE; 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

    		 Endogenous Metabolite Metabolic Disease
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE (15(S)-HETE-SAPE) is a phospholipid containing stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE (HY-113336) at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is formed by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LOX in human peripheral mononuclear cells activated with the calcium ionophore A23187 (HY-N6687).
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
  • HY-P10447
    Plipastatin A1

    Fengycin IX; SNA-60-367-3

    		 Phospholipase Inflammation/Immunology
    Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD .
    Plipastatin A1
  • HY-145473S
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

    15(S)-HETE-SAPE; 15(S)-Hydroxyeicosatetraenoic acid-SAPE-d11; 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11

    		 Isotope-Labeled Compounds Others Metabolic Disease
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 (15(S)-HETE-SAPE-d11) is deuterium labeled 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 (HY-N6687) by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes .
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

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