Search Result

Results for "

IA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Adrenergic Receptor (1) Aminoacyl-tRNA Synthetase (1) Amyloid-β (1) Antibiotic (2) Apoptosis (2) Bacterial (10) Biochemical Assay Reagents (5) Casein Kinase (1) CDK (1) Cholinesterase (ChE) (2) Cytochrome P450 (2) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (2) Estrogen Receptor/ERR (1) GABA Receptor (2) HDAC (1) Histamine Receptor (1) HIV (1) HIV Protease (4) Isotope-Labeled Compounds (1) Kinesin (1) Lipase (1) MAP4K (1) OGA (1) PCSK9 (1) Potassium Channel (6) Raf (1) Reactive Oxygen Species (2) Sodium Channel (4) Tau Protein (1) TRP Channel (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (7) Endocrinology (1) Infection (18) Inflammation/Immunology (10) Metabolic Disease (13) Neurological Disease (3)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136205

IA-Alkyne Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide	TRP Channel	Infection Inflammation/Immunology
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Bacterial Antibiotic	Infection
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-N0556

Isoescin IA	HIV Protease	Infection
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-163102

IA-14069	Others	Inflammation/Immunology
IA-14069 is a TNF-alpha inhibitor that exhibits anti-inflammatory properties while also influencing the production of pro-inflammatory cytokines, making it a valuable tool in colon cancer research.

HY-156029

IA1-8H2	Others	Cancer
IA1-8H2 is a non-covalent, non-competitive inhibitor of PHPT1 (IC₅₀: 3.4 μM). IA1-8H2 can be used for research of lung cancer, hepatocarcinoma, and renal cancer .

HY-14988

I-A09	Bacterial	Infection
I-A09 and its derivatives, specifically 1,2,3-triazole-adamantylacetamide hybrids (5a–u), exhibit significant antitubercular activity. These hybrids were synthesized using copper-catalyzed click chemistry, combining bioactive fragments from antitubercular I-A09 and substituted adamantyl urea. The compound N-(1-adamantyl)-2-azido acetamide was reacted with various alkyl/aryl acetylenes to produce new analogues. Among them, N-(1-adamantan-1-yl)-2-(4-(phenanthren-2-yl)-1H-1,2,3-triazol-1-yl)acetamide (5t) showed the most promise with a minimum inhibitory concentration (MIC) of 3.12 μg/mL against Mycobacterium tuberculosis H37Rv, and a selectivity index greater than 15 .

HY-N0556R

Isoescin IA (Standard)	HIV Protease	Infection
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N1474R

Picfeltarraenin IA (Standard)	Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Picfeltarraenin IA (Standard) is the analytical standard of Picfeltarraenin IA. This product is intended for research and analytical applications. Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-124790

KSP-IA	Kinesin	Cancer
KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis .

HY-N7576

Anemarrhenasaponin Ia	Reactive Oxygen Species	Inflammation/Immunology
Anemarrhenasaponin Ia, isolated from Anemarrhenae rhizome, inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation. Anemarrhenasaponin Ia is an useful anti-inflammation reagent .

HY-N13692

Cinchonain Ia	Others	Others
Cinchonain Ia is a natural product .

HY-N1474

Picfeltarraenin IA	Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-N0554R

Escin IA (Standard)	HIV Protease	Infection Cancer
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N7039

Mogroside IA-(1-3)-glucopyranoside	Others	Metabolic Disease
Mogroside IA-(1-3)-glucopyranoside is isolated from Siraitia grosvenorii.

HY-P5721

Apidaecin IA	Bacterial	Infection
Apidaecin IA is an antibacterial peptide that can be found in honeybees .

HY-N13082

Deacetylescin Ia	Others	Metabolic Disease
Deacetylescin Ia (compound 12) is a deacetylated compound with anti-hyperglycemic effects that can be extracted from the debittered Aesculus and deacetylated at the C-22 position. Deacetylescin Ia (100 mg/kg) can inhibit blood glucose elevation in mouse glucose tolerance tests .

HY-N0554

Escin IA	HIV Protease	Infection Cancer
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC₅₀ values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N6854A

3α-Hydroxymogroside IA1	Others	Metabolic Disease Cancer
3α-Hydroxymogroside IA1 is a mogroside derivative.

HY-116622

α5IA L-822179	GABA Receptor	Neurological Disease
α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential .

HY-163970

*Heparin disaccharide I-A* sodium**	Biochemical Assay Reagents	Others
Heparin disaccharide I-A (sodium)is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W441003

DSPE-PEG-IA (MW 2000)	Biochemical Assay Reagents	Others
DSPE-PEG-IA, MW 2000 is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine. Reagent grade, for research use only.

HY-W440902

DSPE-PEG-IA (MW 3400)	Biochemical Assay Reagents	Others
DSPE-PEG-IA, MW 3400 is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage. Reagent grade, for research use only.

HY-E70304

Mannosyl-oligosaccharide 1,2-α-mannosidase IA MAN1A1	Endogenous Metabolite	Others
Mannosyl-oligosaccharide 1,2-α-mannosidase IA (MAN1A1) is a glycosidase that catalyzes the hydrolysis of α-1,2-linked mannose residues in Man(9)GlcNAc(2) to produce Man(9)GlcNAc(2) .

HY-153391

PCSK9-IN-14	PCSK9	Metabolic Disease
PCSK9-IN-14 (compound Ia-8) is a potent PCSK9 inhibitor .

HY-156256

Insecticidal agent 4	Bacterial	Infection
Insecticidal agent 4 (compound IA-8) is an aryl isoxazoline derivative with insecticidal activity against M. separate .

HY-NP005

Avidin, chiken egg white	Biochemical Assay Reagents	Inflammation/Immunology
Avidin, chicken egg white is a glycoprotein derived from egg protein. Avidin, chicken egg white has excellent affinity with biotin and is often used in combination with biotin for immunoassays to detect the location of antigens in tissues .

HY-W781271

Antitumor agent-160	Others	Cancer
Antitumor agent-160 (compound Ia) is an anticancer compound .

HY-150759

HIV-1 inhibitor-45	HIV	Infection
HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC₅₀ value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity .

HY-B0971S

Pheniramine-d6 maleate Prophenpyridamine-d₆ maleate; Tripoton-d₆ maleate	Isotope-Labeled Compounds Histamine Receptor	Inflammation/Immunology Endocrinology
Pheniramine-d₆ (maleate) is the deuterium labeled Pheniramine maleate. Pheniramine Maleate ia an antihistamine and vasoconstrictor.

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

HY-107204

Furafylline 1 Publications Verification	Cytochrome P450	Cancer
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC₅₀ of 0.07 μM.

HY-N12493

Eucomoside B	Others	Others
Eucomoside B (compound b) ia a natural product isolated from Green Leaves of Eucommia ulmoides .

HY-157313

Pancreatic lipase-IN-1	Lipase	Metabolic Disease
Pancreatic lipase-IN-1 (compound 8) ia a pancreatic lipase inhibitor with the K_i of 1.288 μM .

HY-W440903

DSPE-PEG-IA (MW 5000)	Biochemical Assay Reagents	Others
DSPE-PEG-DBCO, MW 2000 is a cyclooctyne containing phospholipid PEG polymer. The polymer can self-assemble spontaneously in water to form micelles/lipid bilayer. It can be used to prepare nanoparticles or liposomes as drug carrier in targeted drug delivery system. The DBCO can react with azide molecule via copper free click chemistry to form a stable triazole bond. Reagent grade, for research use only.

HY-N11070

23-Epi-26-deoxycimicifugoside	Others	Others
23-Epi-26-deoxycimicifugoside ia a triterpene xyloside that can be isolated from Cimicifuga racemosa .

HY-160218

HPK1-IN-42	MAP4K	Cancer
HPK1-IN-42 (compound 185) ia a HPK1 inhibitor with the IC₅₀ 50 of 0.24 nM .

HY-171036

GAPDH-IN-1	Endogenous Metabolite	Metabolic Disease
GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC₅₀ of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD ⁺, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine .

HY-121076

Berteroin	Bacterial	Infection Inflammation/Immunology Cancer
Berteroin, a naturally occurring Sulforaphane analog, ia an antimetastatic agent. Berteroin has anti-inflammatory, antitumor and bactericidal effects .

HY-120382

LY 215890	Bacterial	Infection
LY 215890 ia an orally active antibacterial agent aganist Escherichia coli EC14 and Klebsiella pneumonia X26 .

HY-112861A

Gln-AMS TFA 1 Publications Verification	Aminoacyl-tRNA Synthetase Bacterial	Infection
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a K_i of 1.32 µM.

HY-P10159

DJK-5	Bacterial	Infection
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .

HY-145120

B-Raf IN 2	Raf	Cancer
B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer .

HY-144681

LY3372689	OGA Tau Protein	Neurological Disease
LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. LY3372689 can be used for tauopathies research, including Alzheimer’s disease .

HY-107204R

Furafylline (Standard)	Cytochrome P450	Cancer
Furafylline (Standard) is the analytical standard of Furafylline. This product is intended for research and analytical applications. Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM.

HY-138802

ML089 1 Publications Verification	Others	Metabolic Disease
ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC₅₀ of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia .

HY-124890

Thr101	Others	Metabolic Disease
Thr101 is an inhibitor (IC₅₀=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .

HY-111378

Casein Kinase II Inhibitor IV	Casein Kinase	Metabolic Disease
Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC₅₀ of 9 nM. Casein Kinase II Inhibitor IV ia also a human keratinocytes (NHEK) differentiation inducer .

HY-111188

A55453	Adrenergic Receptor	Others
A55453 is a prazosin analogue and a potent α1-adrenergic antagonist. ^125I-A55453 is a high-affinity alpha 1-adrenergic receptor probe .

HY-19829

Sandramycin	ADC Cytotoxin Bacterial Antibiotic	Infection Cancer
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity .

HY-163077

Anticancer agent 175	Reactive Oxygen Species Apoptosis	Cancer
Anticancer agent 175 (complex 1) ia a near-infrared (NIR) luminescent theranostic complex. Anticancer agent 175 induces ROS accumulation, mitochondrial damage, disruption of Bax/Bcl-2 equilibrium, and tumor cell apoptosis in HepG2 cell line .

Cat. No.	Product Name	Type

HY-NP005

Avidin, chiken egg white	Native Proteins
Avidin, chicken egg white is a glycoprotein derived from egg protein. Avidin, chicken egg white has excellent affinity with biotin and is often used in combination with biotin for immunoassays to detect the location of antigens in tissues .

HY-163970

Heparin disaccharide I-A sodium

Carbohydrates

Heparin disaccharide I-A (sodium)is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W441003

DSPE-PEG-IA (MW 2000)	Drug Delivery
DSPE-PEG-IA, MW 2000 is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine. Reagent grade, for research use only.

HY-W440902

DSPE-PEG-IA (MW 3400)

Drug Delivery

DSPE-PEG-IA, MW 3400 is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage. Reagent grade, for research use only.

HY-W440903

DSPE-PEG-IA (MW 5000)

Drug Delivery

DSPE-PEG-DBCO, MW 2000 is a cyclooctyne containing phospholipid PEG polymer. The polymer can self-assemble spontaneously in water to form micelles/lipid bilayer. It can be used to prepare nanoparticles or liposomes as drug carrier in targeted drug delivery system. The DBCO can react with azide molecule via copper free click chemistry to form a stable triazole bond. Reagent grade, for research use only.

Cat. No.	Product Name	Target	Research Area

HY-P10136

IA9 human TREM-2 182-190	Peptides	Inflammation/Immunology
IA9 (human TREM-2 182-190) is a TREM-2 inhibitor , and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model .

HY-P10136A

IA9 TFA human TREM-2 182-190 TFA	Peptides	Inflammation/Immunology
IA9 TFA (human TREM-2 182-190 TFA) is a TREM-2 inhibitor , and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model .

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

HY-P5721

Apidaecin IA	Bacterial	Infection
Apidaecin IA is an antibacterial peptide that can be found in honeybees .

HY-P10159

DJK-5	Bacterial	Infection
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .

HY-P5305A

GAD65(247-266) epitope TFA	GABA Receptor	Metabolic Disease
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A ^g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Cyclopeptides Source classification Other Diseases Antibacterial Disease Research Disease Research Fields	Bacterial Antibiotic
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-N0556

Isoescin IA	Other Terpenoids Infection Aesculus chinensis Bunge Classification of Application Fields Terpenoids Hippocastanaceae Source classification Plants Disease Research Fields	HIV Protease
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N1474

Picfeltarraenin IA	Picria felterrae Lour. Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE)
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-N0556R

Isoescin IA (Standard)	Other Terpenoids Aesculus chinensis Bunge Structural Classification Terpenoids Hippocastanaceae Source classification Plants	HIV Protease
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N1474R

Picfeltarraenin IA (Standard)	Picria felterrae Lour. Triterpenes Structural Classification Terpenoids Source classification Scrophulariaceae Plants	Cholinesterase (ChE)
Picfeltarraenin IA (Standard) is the analytical standard of Picfeltarraenin IA. This product is intended for research and analytical applications. Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-N7576

Anemarrhenasaponin Ia	Structural Classification Liliaceae Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids	Reactive Oxygen Species
Anemarrhenasaponin Ia, isolated from Anemarrhenae rhizome, inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation. Anemarrhenasaponin Ia is an useful anti-inflammation reagent .

HY-N13692

Cinchonain Ia	Cinchona succirubra Pav. ex Klotzsch Structural Classification Flavonoids Source classification Rubiaceae Plants Other Flavonoids	Others
Cinchonain Ia is a natural product .

HY-N0554R

Escin IA (Standard)	Triterpenes Structural Classification other families Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants	HIV Protease
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N7039

Mogroside IA-(1-3)-glucopyranoside	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	Others
Mogroside IA-(1-3)-glucopyranoside is isolated from Siraitia grosvenorii.

HY-P5721

Apidaecin IA	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Apidaecin IA is an antibacterial peptide that can be found in honeybees .

HY-N13082

Deacetylescin Ia	Aesculus chinensis Bunge Triterpenes Structural Classification Terpenoids Hippocastanaceae Source classification Plants	Others
Deacetylescin Ia (compound 12) is a deacetylated compound with anti-hyperglycemic effects that can be extracted from the debittered Aesculus and deacetylated at the C-22 position. Deacetylescin Ia (100 mg/kg) can inhibit blood glucose elevation in mouse glucose tolerance tests .

HY-N0554

Escin IA	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants Disease Research Fields Cancer	HIV Protease
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC₅₀ values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N12493

Eucomoside B	Structural Classification Eucommia ulmoides Oliver Iridoids Terpenoids Source classification Eucommiaceae Plants	Others
Eucomoside B (compound b) ia a natural product isolated from Green Leaves of Eucommia ulmoides .

HY-N11070

23-Epi-26-deoxycimicifugoside	Triterpenes Structural Classification Terpenoids Source classification Ranunculaceae Plants Cimicifuga racemosa (L.) Nutt.	Others
23-Epi-26-deoxycimicifugoside ia a triterpene xyloside that can be isolated from Cimicifuga racemosa .

HY-19829

Sandramycin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics	ADC Cytotoxin Bacterial Antibiotic
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity .

HY-N2150

Psammaplin A	Structural Classification Classification of Application Fields Marine natural products Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Animals Antibiotics Phenols Polyphenols Sponge Anticancer Disease Research Fields	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial
Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC₅₀ of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity .

HY-B1167A

Ajmaline hydrochloride Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride	Rauvolfia verticillata (Lour.) Baill. Apocynaceae Structural Classification Natural Products Source classification Plants	Others
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.

Species:	Human (11) Mouse (4) E.coli (1) Canine (1)
Tag:	His (13) Tag Free (2) Myc (1) Fc (4)
Source:	HEK293 (7) P. pastoris (1) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P70848

	IA2 Protein, Human (His) Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	The IA2 protein is critical in the vesicle-mediated secretion process and is essential for the accumulation of secretory vesicles in the hippocampus, pituitary gland, and pancreatic islets. IA2 is critical for insulin-related functions, ensuring normal levels of insulin-containing vesicles, preventing degradation and promoting glucose-stimulated insulin secretion. IA2 Protein, Human (His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70847

	IA2 Protein, Human (293a.a, His, solution) Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	The IA2 protein is critical in the vesicle-mediated secretion process and is essential for the accumulation of secretory vesicles in the hippocampus, pituitary gland, and pancreatic islets. IA2 is critical for insulin-related functions, ensuring normal levels of insulin-containing vesicles, preventing degradation and promoting glucose-stimulated insulin secretion. IA2 Protein, Human (293a.a, His, solution) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70847A

	IA2 Protein, Human (293a.a, N-His) Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	The IA2 protein is critical in the vesicle-mediated secretion process and is essential for the accumulation of secretory vesicles in the hippocampus, pituitary gland, and pancreatic islets. IA2 is critical for insulin-related functions, ensuring normal levels of insulin-containing vesicles, preventing degradation and promoting glucose-stimulated insulin secretion. IA2 Protein, Human (293a.a, N-His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IA2 Protein, Human (293a.a, N-His) is 293 a.a., with molecular weight of ~35 kDa.

HY-P78262

	CD74 Protein, Mouse (224a.a, HEK293, His) CD74; Ii; DHLAG; HLADG; IA-GAMMA; p33; CLIP; INVG34; IA-GAMMA ; II	Mouse	HEK293
	The CD74 protein is significantly expressed in the thymus and lymph nodes, suggesting that it plays a key role in regulating immune system function. Its presence in the thymus, a key site for T cell development, underscores its important role in overseeing key cellular processes required for immune maturation. CD74 Protein, Mouse (224a.a, HEK293, His) is the recombinant mouse-derived CD74 protein, expressed by HEK293 , with N-His labeled tag.

HY-P7070

	IGF-I/IGF-1 Protein, Mouse 5+ Cited Publications rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Mouse	E. coli
	IGF-I/IGF-1 Protein, Mouse is a mitogenic cytokine.

HY-P7018

	IGF-I/IGF-1 Protein, Human (70a.a) Maximum Cited Publications 13 Publications Verification rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Human	E. coli
	IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism.

HY-P72279

	Outer membrane protein F/OmpF Protein, E.coli (His, myc) Outer membrane protein B; Outer membrane protein IA	E.coli	E. coli
	Outer membrane protein F (OmpF) facilitates the formation of pores, enabling the passive diffusion of small molecules across the bacterial outer membrane. Beyond its role in membrane permeability, OmpF serves as a crucial receptor for the bacteriophage T2 and is considered the primary receptor for colicin E5, playing a probable role in the mechanisms associated with these interactions. Outer membrane protein F/OmpF Protein, E.coli (His, myc) is the recombinant E. coli-derived Outer membrane protein F/OmpF protein, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of Outer membrane protein F/OmpF Protein, E.coli (His, myc) is 340 a.a., with molecular weight of ~44.1 kDa.

HY-P70698AF

	Animal-Free IGF-I/IGF-1 Protein, Mouse (His) rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Mouse	E. coli
	The IGF-I/IGF-1 protein is structurally similar to insulin and has potent growth-promoting activity. As a physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, exceeding the efficacy of insulin at lower concentrations. Animal-Free IGF-I/IGF-1 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag.

HY-P75594

	BMPR1A/ALK-3 Protein, Human (HEK293, His) ALK-3; BMPRIA; Bone morphogenetic protein receptor type-1A; SKR5; CD292	Human	HEK293
	BMPR1A/ALK-3 protein (ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, widely expressed in tissues. BMPR1A/ALK-3 protein mediates iron metabolism factor hepcidin expression, interacts with GDF5/6 to regulate chondrocyte differentiation and adipogenesis. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potentia target for pulmonary arterial hypertension (PAH) and other endothelial-mesenchymal transition (EndoMT)-related vascular disorders. Human BMPR1A/ALK-3 has a full length of 532 a.a., with a motif (107-109 a.a.) mediating specificity for BMP ligand. BMPR1A/ALK-3 Protein, Human (HEK293, His) is produced in HEK293 cells, with a C-terminal His-tags.

HY-P703876

	BMPR1A/ALK-3 Protein, Human (HEK293, hFc) ALK-3; BMPRIA; Bone morphogenetic protein receptor type-1A; SKR5; CD292	Human	HEK293

HY-P76173

	BMPR1A/ALK-3 Protein, Canine (HEK293, Fc) Bone morphogenetic protein receptor type-1A; ALK-3; SKR5; CD292; ACVRLK3; BMPR-IA	Canine	HEK293
	BMPR1A/ALK-3 protein (ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, widely expressed in tissues. BMPR1A/ALK-3 protein mediates iron metabolism factor hepcidin expression, interacts with GDF5/6 to regulate chondrocyte differentiation and adipogenesis. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potentia target for pulmonary arterial hypertension (PAH) and other endothelial-mesenchymal transition (EndoMT)-related vascular disorders. BMPR1A/ALK-3 Protein, Canine (HEK293, Fc) is a recombinant protein produced in the HEK293 cells with C-terminal hFc-tag.

HY-P7483

	BMPR1A/ALK-3 Protein, Mouse (HEK293, His-Fc) Bone morphogenetic protein receptor type-1A; ALK-3; SKR5; CD292; ACVRLK3; BMPR-IA	Mouse	HEK293
	BMPR1A/ALK-3 protein (ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, widely expressed in tissues. BMPR1A/ALK-3 protein mediates iron metabolism factor hepcidin expression, interacts with GDF5/6 to regulate chondrocyte differentiation and adipogenesis. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potentia target for pulmonary arterial hypertension (PAH) and other endothelial-mesenchymal transition (EndoMT)-related vascular disorders. Mouse BMPR1A/ALK-3 has a full length of 532 a.a., with a motif (107-109 a.a.) mediating specificity for BMP ligand. BMPR1A/ALK-3 Protein, Mouse (HEK293, His-Fc) is produced in HEK293 cells and has 129 amino acids (Q24-R152), with C-terminal Fc and His-tags.

HY-P7484

	BMPR1A/ALK-3 Protein, Human (HEK293, Fc-His) Bone morphogenetic protein receptor type-1A; ALK-3; SKR5; CD292; ACVRLK3; BMPR-IA	Human	HEK293
	BMPR1A/ALK-3 protein (ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, widely expressed in tissues. BMPR1A/ALK-3 protein mediates iron metabolism factor hepcidin expression, interacts with GDF5/6 to regulate chondrocyte differentiation and adipogenesis. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potentia target for pulmonary arterial hypertension (PAH) and other endothelial-mesenchymal transition (EndoMT)-related vascular disorders. Human BMPR1A/ALK-3 has a full length of 532 a.a., with a motif (107-109 a.a.) mediating specificity for BMP ligand. BMPR1A/ALK-3 Protein, Human (HEK293, Fc-His) is produced in HEK293 cells and has 129 amino acids (Q24-R152), with C-terminal Fc and His-tags.

HY-P71227

	PPM1A Protein, Human (His) Protein Phosphatase 1A; Protein Phosphatase 2C Isoform Alpha; PP2C-Alpha; Protein Phosphatase IA; PPM1A; PPPM1A	Human	E. coli
	PPM1A is a multifunctional enzyme that negatively regulates multiple signaling pathways. It significantly attenuates TGF-β signaling by dephosphorylating SMAD2 and SMAD3, leading to their dissociation from SMAD4, nuclear export, and signal termination. PPM1A Protein, Human (His) is the recombinant human-derived PPM1A protein, expressed by E. coli , with C-6*His labeled tag.

HY-P700093AF

	Animal-Free IGF-I/IGF-1 Protein, Human (His) 1 Publications Verification Somatamedin C; IGF-IA; Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1	Human	E. coli
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. Animal-Free IGF-I/IGF-1 Protein, Human (His) is the recombinant human-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag.

HY-P71792

	TYR Protein, Human (P.pastoris, His) 2 Publications Verification ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	P. pastoris
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (P.pastoris, His) is the recombinant human-derived TYR protein, expressed by P. pastoris , with N-His, N-6*His labeled tag. The total length of TYR Protein, Human (P.pastoris, His) is 359 a.a., with molecular weight of ~48 kDa.

HY-P79018

	TYR Protein, Human (HEK293, His) ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	HEK293
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (HEK293, His) is the recombinant human-derived TYR protein, expressed by HEK293 , with N-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-B0971S

Pheniramine-d6 maleate
Pheniramine-d₆ (maleate) is the deuterium labeled Pheniramine maleate. Pheniramine Maleate ia an antihistamine and vasoconstrictor.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81537

	CD74 Antibody (YA1282) CD74; DHLAG; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-assocIAted invarIAnt chain; IA antigen-assocIAted invarIAnt chain; Ii; p33; CD74	IHC-P	Human
	CD74 Antibody (YA1282) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1282), targeting CD74. CD74 Antibody (YA1282) can be used for IHC-P experiment in human background.

HY-P81112

	IGF 1 Antibody IBP1; IGF 1; IGF I; IGF-1; IGF IA; IGF IB; IGF1; IGFI; IGFIA; Insulin like growth factor 1 (somatomedin C); Full=Insulin-like growth factor I; Insulin Like Growth Factor 1; Insulin like growth factor IA; Insulin like growth factor IB; Mechano growth factor; MGF; Mechano growth factor; MGF; SomatomedIA C; Somatomedin C; IGF1_HUMAN. IGF-I;	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat, Dog
	IGF 1 Antibody is an unconjugated, approximately 7.7/21 kDa, rabbit-derived, anti-IGF 1 polyclonal antibody. IGF 1 Antibody can be used for: WB, IHC-P, IHC-F, IF, ELISA expriments in human, mouse, rat, dog, and predicted: pig, cow, rabbit, sheep background without labeling.

HY-P83362

	Integrin alpha 2 Antibody (YA3107) ITGA2; CD49B; Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein IA; GPIA; VLA-2 subunit alpha; CD49b	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Integrin alpha 2 Antibody (YA3107) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3107), targeting Integrin alpha 2, with a predicted molecular weight of 129 kDa (observed band size: 150 kDa). Integrin alpha 2 Antibody (YA3107) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P82249

	Activin Receptor Type IA Antibody (YA1994) ACTRI; Acvr1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI	WB, IP	Human, Mouse
	Activin Receptor Type IA Antibody (YA1994) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1994), targeting Activin Receptor Type IA, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). Activin Receptor Type IA Antibody (YA1994) can be used for WB, IP experiment in human, mouse background.

HY-P81388

	CD82 Antibody (YA1133) C33; CD82; IA4; Inducible membrane protein; KAI1; Kangai1; SAR2; ST6; Tetraspanin 27; Tspan27	IHC-P	Human
	CD82 Antibody (YA1133) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1133), targeting CD82. CD82 Antibody (YA1133) can be used for IHC-P experiment in human background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-136205

IA-Alkyne Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide		Alkynes
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

IA

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products