Psammaplin A

Cat. No.: HY-N2150 Purity: ≥96.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC₅₀ of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity.

For research use only. We do not sell to patients.

Psammaplin A Chemical Structure

CAS No. : 110659-91-1

Size	Stock	Quantity
100 μg	In-stock	Estimated Time of Arrival: December 31
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 0.9 nM (DAC1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.18 μM Compound: 1, PsA	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 25884112]
A549	IC₅₀	1.76 μM Compound: PsA	Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay	[PMID: 33636429]
A549	GI₅₀	4.5 μM Compound: Psammaplin A	Cytotoxicity against human A549 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay	[PMID: 27460171]
A549	GI₅₀	7.5 μM Compound: 11c	Growth inhibition of human A549 cells after 96 hrs by sulphorhodamine B assay Growth inhibition of human A549 cells after 96 hrs by sulphorhodamine B assay	[PMID: 22280363]
CHO-K1	EC₅₀	0.9 μM Compound: 4	Cytotoxicity against CHO-K1 cells by Alamar blue assay Cytotoxicity against CHO-K1 cells by Alamar blue assay	[PMID: 16962325]
HCT-116	IC₅₀	0.61 μM Compound: PsA	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay	[PMID: 33636429]
HCT-116	IC₅₀	1.62 μM Compound: 1, PsA	Cytotoxicity against human HCT116 cells by SRB assay Cytotoxicity against human HCT116 cells by SRB assay	[PMID: 25884112]
HeLa	IC₅₀	0.05 μM Compound: Psammaplin A	Inhibition of HDAC in human HeLa cells using Fluor deLys as substrate assessed as deacetylation of substrate by fluorescence assay Inhibition of HDAC in human HeLa cells using Fluor deLys as substrate assessed as deacetylation of substrate by fluorescence assay	[PMID: 27460171]
HL-60	GI₅₀	0.29 μM Compound: Psammaplin A	Cytotoxicity against human HL60 cells assessed as reduction in cell growth inhibition after 72 hrs by trypan blue-staining based hemocytometric analysis Cytotoxicity against human HL60 cells assessed as reduction in cell growth inhibition after 72 hrs by trypan blue-staining based hemocytometric analysis	[PMID: 27460171]
HL-60	GI₅₀	0.37 μM Compound: 1; PsA	Growth inhibition of human HL-60 cells after 72 hrs by trypan blue dye based assay Growth inhibition of human HL-60 cells after 72 hrs by trypan blue dye based assay	[PMID: 33488962]
MCF7	GI₅₀	1.27 μM Compound: 11c	Growth inhibition of human MCF7 cells after 96 hrs by sulphorhodamine B assay Growth inhibition of human MCF7 cells after 96 hrs by sulphorhodamine B assay	[PMID: 22280363]
MCF7	GI₅₀	2.26 μM Compound: Psammaplin A	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay	[PMID: 27460171]
MCF7	IC₅₀	5 μM Compound: 1	Antiproliferative activity against human MCF7 cells by neutral red method Antiproliferative activity against human MCF7 cells by neutral red method	[PMID: 16643023]
MCF7	EC₅₀	5.7 μM Compound: 1	Activation of PPARgamma transfected in human MCF7 cells by luciferase reporter gene assay Activation of PPARgamma transfected in human MCF7 cells by luciferase reporter gene assay	[PMID: 16643023]
MDA-MB-231	IC₅₀	1.31 μM Compound: PsA	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability by SRB assay	[PMID: 33636429]
PC-3	GI₅₀	3.52 μM Compound: Psammaplin A	Cytotoxicity against human PC3 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay	[PMID: 27460171]
SK-HEP1	IC₅₀	1.29 μM Compound: PsA	Cytotoxicity against human SK-HEP1 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human SK-HEP1 cells assessed as reduction in cell viability by SRB assay	[PMID: 33636429]
SNU-638	IC₅₀	0.56 μM Compound: PsA	Cytotoxicity against human SNU-638 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human SNU-638 cells assessed as reduction in cell viability by SRB assay	[PMID: 33636429]
T-cell	EC₅₀	0.2 μM Compound: Psammaplin A	Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis	[PMID: 24495105]
WI-38	GI₅₀	3.44 μM Compound: 11c	Growth inhibition of human WI38 cells after 96 hrs by sulphorhodamine B assay Growth inhibition of human WI38 cells after 96 hrs by sulphorhodamine B assay	[PMID: 22280363]

Molecular Weight

664.39

Formula

C₂₂H₂₄Br₂N₄O₆S₂

CAS No.

110659-91-1

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(NCCSSCCNC(/C(CC1=CC(Br)=C(O)C=C1)=N/O)=O)/C(CC2=CC(Br)=C(O)C=C2)=N/O

Structure Classification

Initial Source

Animals

Microorganisms

marine sponge

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 33.3 mg/mL (50.12 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5051 mL	7.5257 mL	15.0514 mL
5 mM	0.3010 mL	1.5051 mL	3.0103 mL
10 mM	0.1505 mL	0.7526 mL	1.5051 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥96.0%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (245 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)

References

[1]. Matthias G J Baud, et al. Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A Against Its Epigenetic Targets. J Med Chem. 2012 Feb 23;55(4):1731-50. [Content Brief]

[2]. Psammaplin A, a Natural Bromotyrosine Derivative From a Sponge, Possesses the [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5051 mL	7.5257 mL	15.0514 mL	37.6285 mL
	5 mM	0.3010 mL	1.5051 mL	3.0103 mL	7.5257 mL
	10 mM	0.1505 mL	0.7526 mL	1.5051 mL	3.7629 mL
	15 mM	0.1003 mL	0.5017 mL	1.0034 mL	2.5086 mL
	20 mM	0.0753 mL	0.3763 mL	0.7526 mL	1.8814 mL
	25 mM	0.0602 mL	0.3010 mL	0.6021 mL	1.5051 mL
	30 mM	0.0502 mL	0.2509 mL	0.5017 mL	1.2543 mL
	40 mM	0.0376 mL	0.1881 mL	0.3763 mL	0.9407 mL
	50 mM	0.0301 mL	0.1505 mL	0.3010 mL	0.7526 mL

Psammaplin A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Psammaplin A

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Psammaplin A Related Antibodies

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Complete Stock Solution Preparation Table

Psammaplin A Related Classifications

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