2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-45

HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity.

For research use only. We do not sell to patients.

HIV-1 inhibitor-45 Chemical Structure

HIV-1 inhibitor-45 Chemical Structure

CAS No. : 2677762-43-3

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1 mg USD 192 In-stock
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
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Based on 1 publication(s) in Google Scholar

HIV-1 inhibitor-45 Related Antibodies

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Description

HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity[1].

IC50 & Target

HIV-1

 

In Vitro

HIV-1 inhibitor-45 (compound IA-6) (5 d) has antiviral activity and low toxicity with CC50 value of 24.7 μM in MT-4 cells[1].
HIV-1 inhibitor-45 (compound IA-6) (Caco-2 cells) contributes to the poormembrane permeability by polyphenolic skeleton[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HIV-1 inhibitor-45 Related Antibodies
Molecular Weight

516.52

Formula

C23H24N4O8S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1N(C(C2=CC(O)=C(O)C(O)=C2)=O)CCN(S(=O)(C3=CC=C(N)C=C3)=O)C1)NCC4=CC=CO4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (193.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9360 mL 9.6802 mL 19.3603 mL
5 mM 0.3872 mL 1.9360 mL 3.8721 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9360 mL 9.6802 mL 19.3603 mL 48.4008 mL
5 mM 0.3872 mL 1.9360 mL 3.8721 mL 9.6802 mL
10 mM 0.1936 mL 0.9680 mL 1.9360 mL 4.8401 mL
15 mM 0.1291 mL 0.6453 mL 1.2907 mL 3.2267 mL
20 mM 0.0968 mL 0.4840 mL 0.9680 mL 2.4200 mL
25 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.9360 mL
30 mM 0.0645 mL 0.3227 mL 0.6453 mL 1.6134 mL
40 mM 0.0484 mL 0.2420 mL 0.4840 mL 1.2100 mL
50 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9680 mL
60 mM 0.0323 mL 0.1613 mL 0.3227 mL 0.8067 mL
80 mM 0.0242 mL 0.1210 mL 0.2420 mL 0.6050 mL
100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.4840 mL
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HIV-1 inhibitor-45 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-452677762-43-3HIVHuman immunodeficiency virusHIV-1 RNase HantiviralMT-4 cellInhibitorinhibitorinhibit

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HIV-1 inhibitor-45
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