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  4. FAZ-3532

FAZ-3532 (compound G3Ia) is an inhibitor of binding to the NTF2L domain of G3BP1/2 that binds to G3BP1 with a Kd of 0.54 μM. FAZ-3532 targets the protein-protein interaction domain of G3BP1/2 and specifically inhibits co-condensation of G3BP1, caprin 1, and RNA in vitro.

For research use only. We do not sell to patients.

FAZ-3532 Chemical Structure

FAZ-3532 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 785 In-stock
Solution
10 mM * 1 mL in DMSO USD 785 In-stock
Solid
1 mg USD 200 In-stock
5 mg USD 500 In-stock
10 mg USD 800 In-stock
25 mg USD 1600 In-stock
50 mg USD 2550 In-stock
100 mg USD 4080 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

FAZ-3532 Related Antibodies

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Description

FAZ-3532 (compound G3Ia) is an inhibitor of binding to the NTF2L domain of G3BP1/2 that binds to G3BP1 with a Kd of 0.54 μM. FAZ-3532 targets the protein-protein interaction domain of G3BP1/2 and specifically inhibits co-condensation of G3BP1, caprin 1, and RNA in vitro[1].

Molecular Weight

713.88

Formula

C38H56FN5O7
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]([C@H](NC([C@H](C(C)(C)O)NC([C@H](CC(C)(C)C)F)=O)=O)C(N[C@H](C)C(N[C@@H](CCOC)C(N(C)CC1=CC=CC=C1)=O)=O)=O)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (175.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4008 mL 7.0040 mL 14.0080 mL
5 mM 0.2802 mL 1.4008 mL 2.8016 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.66%

SDS (251 KB)

COA (248 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4008 mL 7.0040 mL 14.0080 mL 35.0199 mL
5 mM 0.2802 mL 1.4008 mL 2.8016 mL 7.0040 mL
10 mM 0.1401 mL 0.7004 mL 1.4008 mL 3.5020 mL
15 mM 0.0934 mL 0.4669 mL 0.9339 mL 2.3347 mL
20 mM 0.0700 mL 0.3502 mL 0.7004 mL 1.7510 mL
25 mM 0.0560 mL 0.2802 mL 0.5603 mL 1.4008 mL
30 mM 0.0467 mL 0.2335 mL 0.4669 mL 1.1673 mL
40 mM 0.0350 mL 0.1751 mL 0.3502 mL 0.8755 mL
50 mM 0.0280 mL 0.1401 mL 0.2802 mL 0.7004 mL
60 mM 0.0233 mL 0.1167 mL 0.2335 mL 0.5837 mL
80 mM 0.0175 mL 0.0875 mL 0.1751 mL 0.4377 mL
100 mM 0.0140 mL 0.0700 mL 0.1401 mL 0.3502 mL
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FAZ-3532 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAZ-3532FAZ3532FAZ 3532OthersG3BP inhibitorNTF2Lcaprin 1RNAco-condensationInhibitorinhibitorinhibit

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