2. Metabolic Enzyme/Protease Anti-infection
  3. Aminoacyl-tRNA Synthetase Bacterial
  4. Gln-AMS TFA

Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 µM.

For research use only. We do not sell to patients.

Gln-AMS TFA Chemical Structure

Gln-AMS TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 220 In-stock
5 mg USD 550 In-stock
10 mg USD 850 In-stock
25 mg USD 1750 In-stock
50 mg USD 2750 Get quote
100 mg USD 3950 Get quote
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Gln-AMS TFA:

Gln-AMS TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Gln-AMS TFA

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 µM.

IC50 & Target

Ki: 1.32 µM (GlnRS)[1]
In Vitro

Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gln-AMS TFA Related Antibodies
Molecular Weight

588.47

Formula

C17H23F3N8O10S
Appearance

Solid

Color

White to off-white

SMILES

NC1=C2N=CN([C@@H]3O[C@H](COS(=O)(NC([C@@H](N)CCC(N)=O)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 130 mg/mL (220.91 mM; Need ultrasonic)

DMSO : 50 mg/mL (84.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6993 mL 8.4966 mL 16.9932 mL
5 mM 0.3399 mL 1.6993 mL 3.3986 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 4.25 mg/mL (7.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 4.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (42.5 mg/mL) to 900 μL Corn oil, and mix evenly.

  • Protocol 2

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.25 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.6993 mL 8.4966 mL 16.9932 mL 42.4831 mL
5 mM 0.3399 mL 1.6993 mL 3.3986 mL 8.4966 mL
10 mM 0.1699 mL 0.8497 mL 1.6993 mL 4.2483 mL
15 mM 0.1133 mL 0.5664 mL 1.1329 mL 2.8322 mL
20 mM 0.0850 mL 0.4248 mL 0.8497 mL 2.1242 mL
25 mM 0.0680 mL 0.3399 mL 0.6797 mL 1.6993 mL
30 mM 0.0566 mL 0.2832 mL 0.5664 mL 1.4161 mL
40 mM 0.0425 mL 0.2124 mL 0.4248 mL 1.0621 mL
50 mM 0.0340 mL 0.1699 mL 0.3399 mL 0.8497 mL
60 mM 0.0283 mL 0.1416 mL 0.2832 mL 0.7081 mL
80 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.5310 mL
H2O 100 mM 0.0170 mL 0.0850 mL 0.1699 mL 0.4248 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gln-AMS TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gln-AMSAminoacyl-tRNA SynthetaseBacterialtRNA Synthetase, aaRSInhibitorinhibitorinhibit

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