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M-8

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By Targets:	Biochemical Assay Reagents (5) Isotope-Labeled Compounds (1) Succinate Dehydrogenase (1) TRP Channel (2)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Nucleosides and their Analogs (1)

9

Inhibitors & Agonists

4

Biochemical Assay Reagents

1

Natural
Products

3

Recombinant Proteins

1

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

M8-B	TRP Channel	Metabolic Disease
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb) .

Icilin 1 Publications Verification AG-3-5	TRP Channel	Neurological Disease Inflammation/Immunology
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC₅₀=1.4 μM). Icilin is a "super-cooling agent" . Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response .

FR901464	Biochemical Assay Reagents	Cancer
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects .

M8 metabolite of Carvedilol-d5	Isotope-Labeled Compounds	Others
M8 metabolite of Carvedilol-d₅ is the deuterium labeled M8 metabolite of Carvedilol[1].

M8 glycan (Man8) Mannose-8 N-linked oligosaccharide; Oligomannose 8 glycan	Biochemical Assay Reagents	Others
M8 glycan (Man8) (Mannose-8 N-linked oligosaccharide; Oligomannose 8 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

M8 glycan (Man8), procainamide labelled Mannose-8 N-linked oligosaccharide, procainamide labelled; Oligomannose 8 glycan, procainamide labelled	Biochemical Assay Reagents	Others
M8 glycan (Man8), procainamide labelled (Mannose-8 N-linked oligosaccharide, procainamide labelled; Oligomannose 8 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

M8 glycan (Man8), 2-AA labelled Mannose-8 N-linked oligosaccharide, 2-AA labelled; Oligomannose 8 glycan, 2-AA labelled	Biochemical Assay Reagents	Others
M8 glycan (Man8), 2-AA labelled (Mannose-8 N-linked oligosaccharide, 2-AA labelled; Oligomannose 8 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

M8 glycan (Man8), 2-AB labelled Mannose-8 N-linked oligosaccharide, 2-AB labelled; Oligomannose 8 glycan, 2-AB labelled	Biochemical Assay Reagents	Others
M8 glycan (Man8), 2-AB labelled (Mannose-8 N-linked oligosaccharide, 2-AB labelled; Oligomannose 8 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

Succinate dehydrogenase-IN-5	Succinate Dehydrogenase	Infection
Succinate dehydrogenase-IN-5 (Compound M8) is the inhibitor for succinate dehydrogenase. Succinate dehydrogenase-IN-5 interfers with the energy metabolism and growth of fungi, inhibits Rhizoctonia solani, Sclerotinia sclerotiorum, Botrytis cinerea and Fusarium graminearum with EC₅₀ < 0.3 μg/mL .

Cat. No.	Product Name	Type

M8 glycan (Man8) Mannose-8 N-linked oligosaccharide; Oligomannose 8 glycan	Carbohydrates
M8 glycan (Man8) (Mannose-8 N-linked oligosaccharide; Oligomannose 8 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

M8 glycan (Man8), procainamide labelled Mannose-8 N-linked oligosaccharide, procainamide labelled; Oligomannose 8 glycan, procainamide labelled	Carbohydrates
M8 glycan (Man8), procainamide labelled (Mannose-8 N-linked oligosaccharide, procainamide labelled; Oligomannose 8 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

M8 glycan (Man8), 2-AA labelled Mannose-8 N-linked oligosaccharide, 2-AA labelled; Oligomannose 8 glycan, 2-AA labelled	Carbohydrates
M8 glycan (Man8), 2-AA labelled (Mannose-8 N-linked oligosaccharide, 2-AA labelled; Oligomannose 8 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

M8 glycan (Man8), 2-AB labelled Mannose-8 N-linked oligosaccharide, 2-AB labelled; Oligomannose 8 glycan, 2-AB labelled	Carbohydrates
M8 glycan (Man8), 2-AB labelled (Mannose-8 N-linked oligosaccharide, 2-AB labelled; Oligomannose 8 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

Cat. No.	Product Name	Category	Target	Chemical Structure

FR901464	Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	Biochemical Assay Reagents
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects .

Species:	Human (2) Mouse (1)
Tag:	His (3) SUMO (1)
Source:	HEK293 (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	ATP6AP2 Protein, Human (His) APT6M8 9; APT6M8-9; ATP6AP2; ATP6IP2; ATP6M8-9; ATPase H+; -transporting lysosomal accessory protein 2; ATPase H+; -transporting lysosomal-interacting protein 2; ATPase H+ transporting lysosomal accessory protein 2; ATPase; H+ transporting; lysosomal vacuolar proton pump; membrane sector associated protein M8 9;	Human	E. coli
	The multifunctional ATP6AP2 protein serves as a cellular receptor for renin and prorenin, contributing to lysosomal V-ATPase assembly and endolysosomal acidification. It participates in renin-dependent reactions, activates ERK1/2, and may enhance the catalytic efficiency of renin in the renin-angiotensin system. ATP6AP2 Protein, Human (His) is the recombinant human-derived ATP6AP2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ATP6AP2 Protein, Human (His) is 334 a.a., with molecular weight of ~40 kDa.

	ATP6AP2 Protein, Human (His-SUMO) APT6M8 9; APT6M8-9; ATP6AP2; ATP6IP2; ATP6M8-9; ATPase H+; -transporting lysosomal accessory protein 2	Human	E. coli
	The multifunctional ATP6AP2 protein serves as a cellular receptor for renin and prorenin, contributing to lysosomal V-ATPase assembly and endolysosomal acidification. It participates in renin-dependent reactions, activates ERK1/2, and may enhance the catalytic efficiency of renin in the renin-angiotensin system. ATP6AP2 Protein, Human (His-SUMO) is the recombinant human-derived ATP6AP2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of ATP6AP2 Protein, Human (His-SUMO) is 334 a.a., with molecular weight of ~53.5 kDa.

	CADM1/IGSF4A Protein, Mouse (Q8R5M8-2, HEK293, His) Cell adhesion molecule 1; IgSF4; NECL-2; SynCAM; TSLC-1	Mouse	HEK293
	CADM1/IGSF4A proteins coordinate Ca(2+)-independent homophilic and heterophilic cell adhesion with CADM3 and NECTIN3. Interaction with CRTAM enhances NK cell cytotoxicity and CD8+ T cell function. CADM1/IGSF4A Protein, Mouse (Q8R5M8-2, HEK293, His) is the recombinant mouse-derived CADM1/IGSF4A protein, expressed by HEK293 , with C-His labeled tag.

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M8 metabolite of Carvedilol-d5
M8 metabolite of Carvedilol-d₅ is the deuterium labeled M8 metabolite of Carvedilol[1].

Cat. No.	Product Name		Classification

2′-O-Methyl-8-methyl guanosine m8Gm		Nucleosides and their Analogs
2′-O-Methyl-8-methyl guanosine (m8Gm) is a Z-form RNA stabilizer. 2′-O-Methyl-8-methyl guanosine can markedly stabilize the Z-RNA at low salt conditions . m8Gm-contained oligonucleotides stabilize the Z-DNA under low salt conditions .

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