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Results for "

NCI-H524

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W247437
    E3 ligase Ligand 56

    		Ligands for E3 Ligase Cancer
    E3 ligase Ligand 56 is the ligand for E3 ligase Cereblon and can be used for syntheisis of PROTAC CDK9 degrader-11 (HY-170978) .
    E3 ligase Ligand 56
  • HY-170978
    PROTAC CDK9 degrader-11

    		PROTACs CDK Cancer
    PROTAC CDK9 degrader-11 (Compound C3) is an orally active degrader for CDK9 with DC50 of 1.09 nM. PROTAC CDK9 degrader-11 exhibits cytotoxicity in multi small cell lung cancer cell with IC50 of nanomolar levels. PROTAC CDK9 degrader-11 arrests cell cycle at G0/G1 phase, inhibits the cell invasion in DMS114 and DMS53 cell. PROTAC CDK9 degrader-11 exhibits antitumor efficacy in NCI-H446 xenograft mouse models .(Pink: ligand for target protein CDK9 (HY-170979); Black: linker; Blue: ligand for E3 ligase CRBN (HY-W247437))
    PROTAC CDK9 degrader-11
  • HY-170979
    CDK9 ligand 3

    		Ligands for Target Protein for PROTAC CDK Cancer
    CDK9 ligand 3 is the ligand for CDK9 and can be used for synthesis of PROTAC CDK9 degrader-11 .
    CDK9 ligand 3

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