Search Result

Results for "

NK1 receptor antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (1) Cytochrome P450 (2) Drug Metabolite (2) Endogenous Metabolite (2) Interleukin Related (1) Isotope-Labeled Compounds (2) mAChR (1) Mitochondrial Metabolism (1) Neurokinin Receptor (77)
By Research Areas:	Cancer (15) Cardiovascular Disease (2) Endocrinology (18) Infection (2) Inflammation/Immunology (12) Metabolic Disease (1) Neurological Disease (63)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145250

NK1 receptor antagonist 2	Neurokinin Receptor	Neurological Disease
NK1 receptor antagonist 2 is a **NK1 receptor** antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss .

HY-109147A

Imnopitant dihydrochloride	Neurokinin Receptor	Neurological Disease
Imnopitant dihydrochloride is a neurokinin **NK1 receptor** antagonist .

HY-120928

S 16474	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
S 16474 is a cyclic peptide with antagonistic effects on *NK1* and NK2 receptors. S 16474 can be used in the study of neurogenic inflammation .

HY-105346

WIN 51708	Neurokinin Receptor	Neurological Disease
WIN 51708 is a nonpeptide antagonist of neurokinin (NK)-1 receptor. WIN 51708 has a higher affinity for the rat NK-1 receptor compared to the human NK-1 receptor .

HY-106659

SCH 900978 NK-1 antagonist 1	Neurokinin Receptor	Neurological Disease Endocrinology
SCH 900978 (NK-1 Antagonist 1) is an antagonist of **NK-1 receptor*, used in the research of NK-1* related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression .

HY-12142

Vofopitant GR 205171	Neurokinin Receptor	Neurological Disease Endocrinology
Vofopitant is potent tachykinin NK₁ receptor antagonist, with pK_is of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁ receptor, respectively.

HY-12114

Serlopitant VPD-737; MK-0594	Neurokinin Receptor	Neurological Disease Endocrinology
Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.

HY-129296

YM-44781 free acid	Others	Neurological Disease
YM-44781 free acid is a non-peptide neuropeptide receptor antagonist with efficient NK(2) and NK(1) receptor antagonist activity. YM-44781 exhibits significant binding affinity on the NK(2) receptor (pK_i = 9.94) and also on the NK(1) receptor Higher binding affinity (pK_i = 9.09). In addition, YM-44781 also showed significant inhibitory effects on bladder contraction induced by selective NK(1) receptor agonists .

HY-159842

Fosrolapitant	Neurokinin Receptor	Neurological Disease
Fosrolapitant is a neurokinin 1 (NK1) receptor antagonist .

HY-108480

SDZ NKT 343	Neurokinin Receptor	Neurological Disease
SDZ NKT 343 is a selective, orally active **NK₁ receptor** antagonist with an IC₅₀ of 0.62 nM against human NK₁ receptor. SDZ NKT 343 has good analgesic activity .

HY-133206A

Fosnetupitant chloride monohydrochloride 1 Publications Verification Pronetupitant chloride monohydrochloride	Neurokinin Receptor	Cancer
Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an *NK1* antagonist with pK_i values of 9.5, 6.1 for human NK1 and NK3 receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant .

HY-108481

L-760735	Neurokinin Receptor	Neurological Disease
L-760735 is a high affinity, selective and orally active **NK1 receptor** antagonist with an IC₅₀ of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects .

HY-19665

Lanepitant LY303870	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Lanepitant (LY303870) is a selective neurokinin-1 (NK-1) receptor antagonist. Lanepitant blocks neurogenic inflammation and pain transmission by preventing the binding of substance P to *NK-1* receptors on both neuronal and non-neuronal tissues. Lanepitant can be used to study osteoarthritis .

HY-P0061

Vapreotide 1 Publications Verification RC160; BMY 41606	Neurokinin Receptor	Cancer
Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-109147

Imnopitant	Neurokinin Receptor	Neurological Disease Endocrinology
Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .

HY-P0061B

Vapreotide diacetate RC160 diacetate; BMY 41606 diacetate	Neurokinin Receptor	Cancer
Vapreotide diacetate is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-U00207

MEN11467	Neurokinin Receptor	Neurological Disease Endocrinology
MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK₁ receptor antagonist.

HY-G0012

Netupitant metabolite Monohydroxy Netupitant Monohydroxy Netupitant	Neurokinin Receptor Drug Metabolite	Endocrinology
Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-101249

L-732138	Neurokinin Receptor	Neurological Disease Cancer
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human **NK-1 receptors than cloned rat NK-1 receptors*, and has > 1000-fold more potent than human NK-2 and NK-3 receptors*. L-732138 can reduce hyperalgesia and has antitumor action .

HY-G0011

Netupitant metabolite Netupitant N-oxide Netupitant N-oxide	Drug Metabolite	Neurological Disease Endocrinology
Netupitant N-oxide is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-108483

RP 67580	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a K_i value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation .

HY-105436

FR 113680	Neurokinin Receptor	Neurological Disease
FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor .

HY-12143

Vofopitant dihydrochloride GR 205171A	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [ ³H]SP binding to the NK1 receptor with pK_i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent .

HY-10049A

CP 122721 hydrochloride	Neurokinin Receptor	Neurological Disease
CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC₅₀ of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects .

HY-P0061A

Vapreotide acetate 1 Publications Verification RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-12142S

rac-Vofopitant-d3 rac-GR 205171-d₃	Isotope-Labeled Compounds Neurokinin Receptor	Others
rac-Vofopitant-d₃ (rac-GR 205171-d₃) is the deuterium labeled Vofopitant (HY-12142) . Vofopitant is potent tachykinin NK₁ receptor antagonist, with pK_is of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁ receptor, respectively .

HY-P1194B

[D-Pro2] Spantide I TFA	Neurokinin Receptor	Neurological Disease
[D-Pro2] Spantide I TFA is a Spantide analog. Spantide I is a selective NK1 receptor antagonist .

HY-10051

GR203040	Neurokinin Receptor	Neurological Disease
GR203040 is an orally active *NK₁* receptor antagonist with a pK_i of 10.3. GR203040 shows potent antiemetic activity .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective **NK₁ receptor** antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective **NK₁ receptor** antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-17012

Dapitant RPR 100893	Neurokinin Receptor	Inflammation/Immunology
Dapitant (RPR 100893) is a non-peptide Substance P antagonist with high affinity for the human NK1 receptor. It belongs to the 7,7,4-trimethylperhydroisoindole class of compounds. Dapitant inhibits the binding of Substance P to NK1 receptors, thereby blocking its neurokinin-mediated effects. This novel antagonist represents a potential therapeutic option for conditions involving Substance P, such as neurogenic inflammation and pain modulation .

HY-119005A

YM-49598 iodide	Neurokinin Receptor	Neurological Disease
YM-49598 iodide is a tachykinin NK-1 receptor antagonist. YM-49598 iodide can inhibit drug-induced bladder contraction in rats, with IC₅₀ of 11 μg/kg .

HY-117216

L-703606	Neurokinin Receptor	Neurological Disease
L-703606 is a potent, selective antagonist of *NK1* receptor. L-703606 can be used for study of gastric acid secretion .

HY-117216A

L-703606 oxalate	Neurokinin Receptor	Neurological Disease
L-703606 oxalate is a potent, selective antagonist of *NK1* receptor. L-703606 can be used for study of gastric acid secretion .

HY-117216B

L-703606 oxalate hydrate	Neurokinin Receptor	Neurological Disease
L-703606 oxalate hydrate is a potent, selective antagonist of *NK1* receptor. L-703606 can be used for study of gastric acid secretion .

HY-P10588

WIN 66306	Neurokinin Receptor	Others
WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both *NK1* and NK2 receptors .

HY-18006

NKP608 1 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.

HY-16346S

Netupitant-d6 CID-6451149-d₆	Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for *NK-1, NK-2,and NK-3* receptor, respectively .

HY-108479

Nolpitantium SR140333	Neurokinin Receptor	Neurological Disease
Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin **NK₁ receptor** antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-116958

SCH 206272	Neurokinin Receptor	Inflammation/Immunology
SCH 206272 is a selective antagonist of the tachykinin (NK) receptor. SCH 206272 inhibits binding at human tachykinin NK(1), NK(2), and NK(3) receptors (K_i = 1.3, 0.4, and 0.3 nM, respectively). SCH 206272 has an orally active .

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-118378

ZD6021	Neurokinin Receptor	Neurological Disease Endocrinology
ZD6021 is an orally active Neurokinin 1 Receptor antagonist, with K_i values of 0.12 nM for *NK1* and 0.62 nM for NK2. At a concentration of 100 nM, ZD6021 has a pK_B value of 8.9 for human pulmonary artery *NK1* receptors, and a pK_B value of 7.3 for human bronchial NK2 receptors. ZD6021 effectively reduces ASMSP-induced plasma protein extravasation in guinea pigs, with an ED₅₀ of 0.5 mg/kg, and also decreases NK2 mediated bronchoconstriction, with an ED₅₀ of 13 mg/kg .

HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P	Neurokinin Receptor	Neurological Disease
(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective **NK₁ receptor** antagonist .

HY-118463

Benzomalvin A	Neurokinin Receptor	Neurological Disease
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively .

HY-118356

WIN 62,577	Neurokinin Receptor mAChR	Neurological Disease
WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.

HY-10053

Maropitant	Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting .

HY-16346

Netupitant 3 Publications Verification CID 6451149	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect .

Cat. No.	Product Name	Target	Research Area

HY-P0061

Vapreotide 1 Publications Verification RC160; BMY 41606	Neurokinin Receptor	Cancer
Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P0061A

Vapreotide acetate 1 Publications Verification RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P1194B

[D-Pro2] Spantide I TFA	Neurokinin Receptor	Neurological Disease
[D-Pro2] Spantide I TFA is a Spantide analog. Spantide I is a selective NK1 receptor antagonist .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective **NK₁ receptor** antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective **NK₁ receptor** antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1193

GR 82334	Peptides	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .

HY-P0061B

Vapreotide diacetate RC160 diacetate; BMY 41606 diacetate	Neurokinin Receptor	Cancer
Vapreotide diacetate is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-105436

FR 113680	Neurokinin Receptor	Neurological Disease
FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor .

HY-P10588

WIN 66306	Neurokinin Receptor	Others
WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both *NK1* and NK2 receptors .

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for *NK-1, NK-2,and NK-3* receptor, respectively .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P	Neurokinin Receptor	Neurological Disease
(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective **NK₁ receptor** antagonist .

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P10619

[Tyr6,D-Phe7,D-His9]-Substance P (6-11)	Neurokinin Receptor	Inflammation/Immunology
[Tyr6,D-Phe7,D-His9]-Substance P (6-11) is a tachykinin *NK1* receptor antagonist that antagonizes Histamine (HY-B1204) induced hyperalgesia .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-P1722

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011978

N-Acetyl-L-tryptophan	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to *NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β* and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-118463

Benzomalvin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Quinoline Alkaloids Endogenous metabolite	Neurokinin Receptor
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively .

HY-119552

Acetylaszonalenin LL-S490β	Alkaloids Microorganisms Source classification Indole Alkaloids	Endogenous Metabolite Neurokinin Receptor
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-116620

Benzomalvin C	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Neurokinin Receptor
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC₅₀ value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

Cat. No.	Product Name	Chemical Structure

HY-16346S

Netupitant-d6
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-12142S

rac-Vofopitant-d3
rac-Vofopitant-d₃ (rac-GR 205171-d₃) is the deuterium labeled Vofopitant (HY-12142) . Vofopitant is potent tachykinin NK₁ receptor antagonist, with pK_is of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁ receptor, respectively .

HY-10053S1

Maropitant-13C,d3
Maropitant- ¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting[1][2].

Cat. No.	Product Name		Classification

HY-105346

WIN 51708		Alkynes
WIN 51708 is a nonpeptide antagonist of neurokinin (NK)-1 receptor. WIN 51708 has a higher affinity for the rat NK-1 receptor compared to the human NK-1 receptor .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

NK1 receptor antagonist

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products