2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Lanepitant

Lanepitant (LY303870) is a selective neurokinin-1 (NK-1) receptor antagonist. Lanepitant blocks neurogenic inflammation and pain transmission by preventing the binding of substance P to NK-1 receptors on both neuronal and non-neuronal tissues. Lanepitant can be used to study osteoarthritis.

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Lanepitant Chemical Structure

Lanepitant Chemical Structure

CAS No. : 170566-84-4

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Based on 1 publication(s) in Google Scholar

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Description

Lanepitant (LY303870) is a selective neurokinin-1 (NK-1) receptor antagonist. Lanepitant blocks neurogenic inflammation and pain transmission by preventing the binding of substance P to NK-1 receptors on both neuronal and non-neuronal tissues. Lanepitant can be used to study osteoarthritis[1].

Cellular Effect
Cell Line Type Value Description References
IM-9 IC50
0.15 nM
Compound: 32(R)
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
[PMID: 8576917]
Molecular Weight

559.74

Formula

C33H45N5O3
CAS No.
SMILES

O=C(N[C@H](CC1=CNC2=C1C=CC=C2)CN(C(C)=O)CC3=CC=CC=C3OC)CN4CCC(N5CCCCC5)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lanepitant Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lanepitant170566-84-4LY303870LY 303870LY-303870Neurokinin ReceptorNK receptorTachykinin receptorAntagonistsneurogenic inflammationpain transmissionosteoarthritisNK-1Inhibitorinhibitorinhibit

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