FR 113680 

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor^[1].

The inhibitory effect of FR 113680 on SP-induced guinea-pig ileum contraction is competitive and the pA₂ value is 7.53^[1].
FR 113680 has not effect on [³H]-SP binding to rat cerebral cortical membranes (NK₁), [³H]-neurokinin A ([³H]-NKA) binding to rat duodenum smooth muscle membranes (NK₂) and [³H]-eledoisin (Ele) binding to rat cerebral cortical membranes (NK₃)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FR 113680 (32 mg/kg; i.v.; once) significantly inhibits cigarette smoke-induced plasma extravasation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

625.71

C₃₅H₃₉N₅O₆

126088-92-4

Ac-Thr-{d-Trp(For)}-{Phe(NMe,Bzl)}

Ac-T-{d-Trp(For)}-{Phe(NMe,Bzl)}

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Morimoto H, et al. FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity. Br J Pharmacol. 1992 May;106(1):123-6.  [Content Brief]

  [2]. Morimoto H, et al. Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation. Eur J Pharmacol. 1992 Nov 24;224(1):1-5.  [Content Brief]