2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. FR 113680

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor.

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FR 113680 Chemical Structure

FR 113680 Chemical Structure

CAS No. : 126088-92-4

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Description

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor[1]. In Vitro:The inhibitory effect of FR 113680 on SP-induced guinea-pig ileum contraction is competitive and the pA2 value is 7.53[1].
FR 113680 has not effect on [3H]-SP binding to rat cerebral cortical membranes (NK1), [3H]-neurokinin A ([3H]-NKA) binding to rat duodenum smooth muscle membranes (NK2) and [3H]-eledoisin (Ele) binding to rat cerebral cortical membranes (NK3)[1]. In Vivo:FR 113680 (32 mg/kg; i.v.; once) significantly inhibits cigarette smoke-induced plasma extravasation[2].

In Vivo
Animal Model: Male Wistar rats, cigarette smoke-induced rat tracheal plasma extravasation model[2]
Dosage: 0, 10 and 32 mg/kg
Administration: IV, once
Result: Significantly inhibited cigarette smoke-induced rat tracheal plasma extravasation at a dose of 32 mg/kg.
Molecular Weight

625.71

Formula

C35H39N5O6
CAS No.
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Purity & Documentation
References
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FR 113680 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FR 113680126088-92-4FR113680FR-113680Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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