2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. L-760735

L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects.

For research use only. We do not sell to patients.

L-760735 Chemical Structure

L-760735 Chemical Structure

CAS No. : 188923-01-5

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5 mg USD 492 Ask For Quote & Lead Time
10 mg USD 787 Ask For Quote & Lead Time

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L-760735 Related Antibodies

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Description

L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects[1].

IC50 & Target

hNK1

0.19 nM (IC50)

Molecular Weight

611.98

Formula

C26H29ClF7N5O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@@H](OCC2)[C@@](C3=CC=C(C=C3)F)([H])N2CC4=C(N=NN4)CN(C)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30.6 mg/mL (50.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6340 mL 8.1702 mL 16.3404 mL
5 mM 0.3268 mL 1.6340 mL 3.2681 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6340 mL 8.1702 mL 16.3404 mL 40.8510 mL
5 mM 0.3268 mL 1.6340 mL 3.2681 mL 8.1702 mL
10 mM 0.1634 mL 0.8170 mL 1.6340 mL 4.0851 mL
15 mM 0.1089 mL 0.5447 mL 1.0894 mL 2.7234 mL
20 mM 0.0817 mL 0.4085 mL 0.8170 mL 2.0426 mL
25 mM 0.0654 mL 0.3268 mL 0.6536 mL 1.6340 mL
30 mM 0.0545 mL 0.2723 mL 0.5447 mL 1.3617 mL
40 mM 0.0409 mL 0.2043 mL 0.4085 mL 1.0213 mL
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L-760735 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-760735188923-01-5L760735L 760735Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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