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SOS1 Ligand intermediate-7

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169371
    SOS1 Ligand intermediate-7

    		Drug intermediate Others
    SOS1 Ligand intermediate-7 (65) is an intermediate for the synthesis of SOS1 ligand (HY-111671). SOS1 Ligand intermediate-7 (65) can be used for the synthesis of PROTAC SOS1 degrader-1 (HY-145737) .
    SOS1 Ligand intermediate-7
  • HY-162281
    PROTAC SOS1 degrader-6

    		PROTACs Ras Cancer
    PROTAC SOS1 degrader-6 (compound 23) is an effective SOS1 PROTACs degrader that synergizes with KRAS G12C inhibitors . PROTAC SOS1 degrader-6 consists of the target protein ligand (red part) SOS1 Ligand intermediate-7 (HY-169371), E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and PROTAC linker (black part) 5-Bromopentanoic acid (HY-W016456). Among them, the E3 ubiquitin ligase ligand + linker can form (S,R,S)-AHPC-CO-C4-bromine (HY-169372).
    PROTAC SOS1 degrader-6

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