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SOS1-IN-18

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-172221
    SOS1-IN-18

    		Ras ERK Cancer
    SOS1-IN-18 (Compound 8) is the inhibitor for Son of Sevenless 1 protein (SOS1) with a KD of 2.6 nM, and inhibits SOS1-KRAS G12C interaction with an IC50 of 3.4 nM. SOS1-IN-18 inhibits the phosphorylation of ERK in H358 with an IC50 of 31 nM, inhibits the proliferation of H358 with an IC50 of 5 nM .
    SOS1-IN-18

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