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TYD68

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W007732B
    Cyclohexane-1,4-diamine

    1,4-Diaminocyclohexane

    		 PROTAC Linkers Inflammation/Immunology
    Cyclohexane-1,4-diamine (1,4-Diaminocyclohexane) is a PROTAC Linker and can be used for PROTAC synthesis, such as TYD-68 (HY-173357) .
    Cyclohexane-1,4-diamine
  • HY-173357
    TYD-68

    		PROTACs JAK STAT Inflammation/Immunology
    TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 can selectively degrade TYK2 protein through the ubiquitin-proteasome pathway and significantly inhibit IL-12 and IFN-α-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis. (Pink: Target protein ligand (HY-173359); Black: Linker (HY-W007732B); Blue: E3 ligase ligand (HY-14658); E3 ligase ligand + Linker (HY-173358)) .
    TYD-68

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