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VISTA-IN-4

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168949
    VISTA-IN-4

    		VISTA Inflammation/Immunology Cancer
    VISTA-IN-4 (Compound B3) is the orally active inhibitor for immune checkpoint protein VISTA with a KD of 0.452 μM. VISTA-IN-4 degrades VISTA in HepG2 with a 77% degradation rate at 5 μM. VISTA-IN-4 activates VISTA-mediated immunosuppression, restores T cell activity, and promotes the release of cytokine IL-2. VISTA-IN-4 exhibits antitumor activity in CT26 xenograft mouse models, and exhibits good pharmacokinetic properties with a good oral exposure in serum with an AUC(0-t) of 412.9 mg·h/mL in SD rats .
    VISTA-IN-4

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