2. Signaling Pathways
  3. VISTA

VISTA

V-domain Ig suppressor of T cell activation (VISTA)

V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel inhibitory immune checkpoints (ICs) that is expressed on myeloid cells, lymphoid cells, and tumoral cells; therefore, VISTA can substantially regulate innate and

adaptive anti-tumoral immune responses. VISTA is a transmembrane protein that plays a crucial role in the regulation of antitumor immunity. Therapeutic intervention that inhibits the VISTA pathway constitutes a new approach in the treatment of cancer.

VISTA Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Q25865
    MG-V-53
    		Inhibitor
    MG-V-53 is a potent small molecule V domain T-cell activating immunoglobulin suppressor (VISTA) inhibitor with IC50 value of 121 nM. MG-V-53 has antitumor activity.
    MG-V-53
  • HY-169853
    M351-0056
    		Agonist
    M351-0056 is the agonist for the immune checkpoint protein VISTA, that reduces the secretion of VISTA-induced cytokines, promotes the T-cell proliferation induced by VISTA, and exhibits immunomodulatory activity. M351-0056 ameliorates Imiquimod (HY-B0180)-induced psoriatic dermatitis in mouse models.
    M351-0056