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anti-Multidrug resistance (MDR)

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168953
    Lysosomal P-gp targeted agent 1

    		P-glycoprotein Apoptosis Bcl-2 Family Reactive Oxygen Species Caspase Cancer
    Lysosomal P-gp targeted agent 1 (Compound 14) is an anti-tumor agent targeting lysosomal P-glycoprotein (Pgp). Lysosomal P-gp targeted agent 1 is selectively transported into lysosomes by overexpressed Pgp, release nitric oxide (NO) to generate reactive oxygen species (ROS), resulting in lysosomal membrane permeabilization (LMP) and inducing apoptosis. Lysosomal P-gp targeted agent 1 can overcome P-glycoprotein-mediated drug resistance and lead to cell cycle arrest, but relatively low toxicity to normal cells. Lysosomal P-gp targeted agent 1 has antitumor activity, significantly inhibits tumor volume .
    Lysosomal P-gp targeted agent 1

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