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Results for "

bicyclic

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

1

Screening Libraries

1

Biochemical Assay Reagents

9

Peptides

8

Natural
Products

2

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136561
    GRK5-IN-2

    		G Protein-coupled Receptor Kinase (GRK) Metabolic Disease
    GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research .
    GRK5-IN-2
  • HY-W570888
    2'-O,4'-C-Methylenecytidine

    LNA-C(Bz)

    		 Nucleoside Antimetabolite/Analog Cancer
    2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands .
    2'-O,4'-C-Methylenecytidine
  • HY-163289
    TSLP binder-1

    		Others Inflammation/Immunology
    TSLP binder-1 (compound 46) is a bicyclic peptide, which binds to thymic stromal lymphopoietin (TSLP) at the site used by IL-7Rα subunit, shows high affinity for TSLP, with KD of 13 nM. TSLP binder-1 reveals good stability in rat plasma and rat lung S9 fraction .
    TSLP binder-1
  • HY-107025
    Cf1743

    		Others Infection
    Cf1743 is a potent anti-varicella-zoster virus (VZV) bicyclic nucleoside analogue. Cf1743 has antiviral activity, with an IC50 of 3.3 μM for VZV thymidine kinase (TK) .
    Cf1743
  • HY-10116
    PI-540

    		PI3K mTOR Cancer
    PI-540 is a bicyclic thienopyrimidine derivative and an orally active PI3K inhibitor. PI-540 has anti-cancer cell proliferation properties and high tissue distribution. PI-540 can inhibit different isoforms of PI3K, with IC50s of 10 nM (P110α), 3510 nM (P110β), 410 nM (P110δ), and 33110 nM (P110γ). PI-540 also inhibits mTOR (IC50: 61 nM) and DNA-PK (IC50: 525 nM) .
    PI-540
  • HY-108943
    Sabinene
    1 Publications Verification

    		 Others Others
    Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways .
    Sabinene
  • HY-N7366
    Taxachitriene A

    		Others Others
    Taxachitriene A is a bicyclic taxane diterpenoid that can be found in the needles of Taxus chinensis .
    Taxachitriene A
  • HY-N10793
    RA-XI

    		Others Cancer
    RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity .
    RA-XI
  • HY-W068697
    3-Butenoic acid

    Vinylacetic acid

    		 Others Others
    3-Butenoic acid (Vinylacetic acid) can be used to synthesize bicyclic 3,6-dihydro-1,2-oxazine. Strained bicyclic 3,6-dihydro-1,2-oxazine is a reactive substrate in domino metathesis with an external alkene .
    3-Butenoic acid
  • HY-111639
    2’-O,4’-C-Methyleneuridine

    		Nucleoside Antimetabolite/Analog Others
    2’-O,4’-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
    2’-O,4’-C-Methyleneuridine
  • HY-N10663A
    (±)-7-epi-Kadsurenone

    		Others Others
    (±)-7-epi-Kadsurenone is a novel lignan with hydrobenzofuran and bicyclic [3.2.1] octane. .
    (±)-7-epi-Kadsurenone
  • HY-111638
    1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Infection
    1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
    1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine
  • HY-126027
    (+)-3-Carene

    		Others Inflammation/Immunology
    (+)-3-Carene, a bicyclic monoterpene, is one of the major components of the pine tree essential oils. (+)-3-Carene is a (+)-enantiomer of 3-Carene .
    (+)-3-Carene
  • HY-139798
    Iboxamycin

    		Bacterial Infection
    Iboxamycin is a potent antibiotic candidate bearing a fused bicyclic amino acid residue. Iboxamycin is orally bioavailable, safe and effective in researching both Gram-positive and Gram-negative bacterial infections in mice .
    Iboxamycin
  • HY-161423
    Antimicrobial agent-28

    		Bacterial Infection
    Antimicrobial agent-28 (Compound Bicycle molecule) is an antibacterial agent with good affinity for the penicillin-binding protein (PBP3) of Escherichia coli, which can inhibit the activity of Escherichia coli .
    Antimicrobial agent-28
  • HY-N11977
    Stenophyllol B

    		Others Others
    Stenophyllol B (compound 4) is a trimeric stilbene with bicyclic and bridged tricyclic skeletons. Stenophyllol B was first discovered in the dipterocarps plant and has been found in many species of Hopea, Neobalanocarpus, Shorea, Stemonoporus and Vateri .
    Stenophyllol B
  • HY-134772
    AS1810722

    		STAT Cytochrome P450 Inflammation/Immunology
    AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .
    AS1810722
  • HY-149872
    DCA-RMR1

    		Biochemical Assay Reagents Others
    DCA-RMR1 is a cross-linker. DCA-RMR1 elicits facile bicyclization of native peptides via N-terminus Cys-Cys cross-linking. DCA-RMR1 derivatizes RMR1 with 1,3-dichloroacetone (DCA) .
    DCA-RMR1
  • HY-N6663
    3-Carene

    		COX Inflammation/Immunology
    3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation .
    3-Carene
  • HY-P10033
    SFTI-1

    		Ser/Thr Protease Others
    SFTI-1 is a cyclic peptide trypsin inhibitor comprising 14 amino acid residues. SFTI-1 is a potent Bowman-Birk inhibitor.
    SFTI-1
  • HY-109016
    Valnivudine

    FV-100 free base

    		 Antibiotic Bacterial Infection
    Valnivudine (FV-100 free base), a proagent of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV). Valnivudine is rapidly and extensively converted to CF-1743 in vivo .
    Valnivudine
  • HY-N5132
    (-)-Fenchone

    		Others Others
    (-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Foeniculum vulgare. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6 .
    (-)-Fenchone
  • HY-150568
    SIRT1/2/3-IN-1

    		Sirtuin Cancer
    SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of SIRT1, SIRT2 and SIRT3 with IC50s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer .
    SIRT1/2/3-IN-1
  • HY-151829
    Fmoc-L-Asn(EDA-N3)-OH

    		ADC Linker Others
    Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II .
    Fmoc-L-Asn(EDA-N3)-OH
  • HY-P10027
    Clovibactin

    		Antibiotic Bacterial Infection
    Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
    Clovibactin
  • HY-P10027A
    Clovibactin TFA

    		Antibiotic Bacterial Infection
    Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
    Clovibactin TFA
  • HY-P1206
    CH 275

    		Somatostatin Receptor Neurological Disease
    CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM . CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively . CH 275 can be used for the research of alzheimer’s disease .
    CH 275
  • HY-W111141
    BCN-OH

    endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne

    		 Biochemical Assay Reagents Others
    BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .
    BCN-OH
  • HY-P10298
    RA-XII

    		Autophagy Apoptosis Akt mTOR Inflammation/Immunology Cancer
    RA-XII is bicyclic hexapeptidic glucoside , which exhibits antitumor and anti-inflammatory activity. RA-XII activates Akt-mTOR singaling pathway, inhibits the formation of autophagosomes, and thus suppresses autophagy. RA-XII induces apoptosis through AMPK/mTOR/P70S6K pathway. RA-XII inhibit metastasis via reducing cell adhesion and invasion in breast cancer cells. RA-XII attenuates anti-inflammatory efficacy against acute kidney injury through HO-1/Nrf2 pathway .
    RA-XII

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