2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 2'-O,4'-C-Methylenecytidine

2'-O,4'-C-Methylenecytidine  (Synonyms: LNA-C(Bz))

Cat. No.: HY-W570888 Purity: 98.59%
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2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands.

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2'-O,4'-C-Methylenecytidine Chemical Structure

2'-O,4'-C-Methylenecytidine Chemical Structure

CAS No. : 206055-69-8

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2'-O,4'-C-Methylenecytidine Related Antibodies

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Description

2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands[1][2].

Molecular Weight

255.23

Formula

C10H13N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@]1(CO2)[C@@H](O)[C@@H]2[C@H](N3C=CC(N)=NC3=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (391.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9180 mL 19.5902 mL 39.1803 mL
5 mM 0.7836 mL 3.9180 mL 7.8361 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9180 mL 19.5902 mL 39.1803 mL 97.9509 mL
5 mM 0.7836 mL 3.9180 mL 7.8361 mL 19.5902 mL
10 mM 0.3918 mL 1.9590 mL 3.9180 mL 9.7951 mL
15 mM 0.2612 mL 1.3060 mL 2.6120 mL 6.5301 mL
20 mM 0.1959 mL 0.9795 mL 1.9590 mL 4.8975 mL
25 mM 0.1567 mL 0.7836 mL 1.5672 mL 3.9180 mL
30 mM 0.1306 mL 0.6530 mL 1.3060 mL 3.2650 mL
40 mM 0.0980 mL 0.4898 mL 0.9795 mL 2.4488 mL
50 mM 0.0784 mL 0.3918 mL 0.7836 mL 1.9590 mL
60 mM 0.0653 mL 0.3265 mL 0.6530 mL 1.6325 mL
80 mM 0.0490 mL 0.2449 mL 0.4898 mL 1.2244 mL
100 mM 0.0392 mL 0.1959 mL 0.3918 mL 0.9795 mL
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2'-O,4'-C-Methylenecytidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-O,4'-C-Methylenecytidine206055-69-8LNA-C(Bz)Nucleoside Antimetabolite/Analogbicyclic nucleoside analogueN-type conformationsynthesize oligonucleotidesduplexesInhibitorinhibitorinhibit

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