2. MAPK/ERK Pathway
  3. p38 MAPK
  4. Sabinene

Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways.

For research use only. We do not sell to patients.

Sabinene Chemical Structure

Sabinene Chemical Structure

CAS No. : 3387-41-5

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 69 In-stock
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Liquid
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500 mg USD 132 In-stock
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Based on 2 publication(s) in Google Scholar

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2 Publications Citing Use of MCE Sabinene

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways[1][2].

In Vitro

Sabinene (10-300 μM; 18 h) induces predominant recovery of reductions of myotube diameters under starvation[2].
Sabinene (300 μM; 18 h) diminishes the elevated E3 ubiquitin ligase muscle ring-finger protein-1 (MuRF-1) expression and p38 mitogen-activated protein kinase (MAPK), and attenuates extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylations in starved myotubes[2].
Sabinene (300 μM; 18 h) decreases the increased level of reactive oxygen species (ROS) in myotubes under starvation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: IL-6 myoblasts
Concentration: 300 μM
Incubation Time: 18 and 48 hours
Result: Failed to affect the viability of IL-6 myoblasts after 48 h incubation and recovered more than 50% of starvation-induced myoblast atrophy after 18 h.

Western Blot Analysis[2]

Cell Line: IL-6 myoblasts
Concentration: 300 μM
Incubation Time: 18 hours
Result: Attenuated muscle atrophy-related signaling proteins phosphorylation in starved myotubes.
In Vivo

Sabinene (6.4 mg/kg; p.o.; once daily; during the fasting for 2 d) attenuates skeletal muscle atrophy by regulating the activation mechanism of ROS-mediated MAPK/MuRF-1 pathways in starved myotubes, probably leading to the reverse of reduced muscle fiber size in fasted rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fasted animal model in rat[2]
Dosage: 6.4 mg/kg
Administration: Oral gavage; once daily; during the fasting for 2 days
Result: Reduced the levels of muscle fiber atrophy and MuRF-1 expression in gastrocnemius from fasted rats.
Molecular Weight

136.24

Formula

C10H16
CAS No.
Appearance

Liquid (Density: 0.842 g/cm3)

Color

Colorless to light yellow

SMILES

CC(C12CCC(C1C2)=C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (734.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3401 mL 36.7005 mL 73.4010 mL
5 mM 1.4680 mL 7.3401 mL 14.6802 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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Volume (final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (36.70 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.3401 mL 36.7005 mL 73.4010 mL 183.5024 mL
5 mM 1.4680 mL 7.3401 mL 14.6802 mL 36.7005 mL
10 mM 0.7340 mL 3.6700 mL 7.3401 mL 18.3502 mL
15 mM 0.4893 mL 2.4467 mL 4.8934 mL 12.2335 mL
20 mM 0.3670 mL 1.8350 mL 3.6700 mL 9.1751 mL
25 mM 0.2936 mL 1.4680 mL 2.9360 mL 7.3401 mL
30 mM 0.2447 mL 1.2233 mL 2.4467 mL 6.1167 mL
40 mM 0.1835 mL 0.9175 mL 1.8350 mL 4.5876 mL
50 mM 0.1468 mL 0.7340 mL 1.4680 mL 3.6700 mL
60 mM 0.1223 mL 0.6117 mL 1.2233 mL 3.0584 mL
80 mM 0.0918 mL 0.4588 mL 0.9175 mL 2.2938 mL
100 mM 0.0734 mL 0.3670 mL 0.7340 mL 1.8350 mL
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Sabinene Related Classifications

Keywords:

Sabinene3387-41-5p38 MAPKflavoringsperfume additivesfine chemicalsadvanced biofuelbicyclic monoterpeneChrysanthemum borealeMakino essential oilskeletal muscle atrophyL6 cellsInhibitorinhibitorinhibit

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