2. Anti-infection
  3. Antibiotic Bacterial
  4. Clovibactin TFA

Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Clovibactin TFA Chemical Structure

Clovibactin TFA Chemical Structure

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500 μg USD 750 In-stock
1 mg USD 1200 In-stock
5 mg USD 3000 In-stock
10 mg USD 4800 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Clovibactin TFA:

Clovibactin TFA Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors[1].

In Vitro

Clovibactin TFA inhibits Staphylococcus strains with MICs of 0.125-2 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clovibactin TFA Related Antibodies
In Vivo

Clovibactin TFA (20 mg/kg, iv, single dose) exhibits a pharmacokinetic profil with a Cmax of 219.3 μg/mL, an AUCto last of 31.9 μg·h/mL, t1/2 of 2 h, CL of 9.4 mL/kg/min and a Vdss of 189.8 mL/kg in mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

903.08 (free base)

Formula

C43H70N10O11.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Phe-{d-Leu}-{d-Lys}-Ser-{Hyn}-Ala-Leu-Leu (Cyclic ester: Hyn5-Leu8)
Sequence Shortening

F-{d-Leu}-{d-Lys}-S-{Hyn}-ALL (Cyclic ester: Hyn5-Leu8)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
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Clovibactin TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ClovibactinAntibioticBacterialStaphylococcusStaphylococcus aureusCD-1 miceInhibitorinhibitorinhibit

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HY-P10027A
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