2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. CH 275

CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM. CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively. CH 275 can be used for the research of alzheimer’s disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CH 275 Chemical Structure

CH 275 Chemical Structure

CAS No. : 174688-78-9

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1 mg USD 260 In-stock
5 mg USD 830 In-stock
10 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of CH 275:

CH 275 Related Antibodies

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • Biological Activity

  • Purity & Documentation

  • References

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Description

CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM[1]. CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively[2]. CH 275 can be used for the research of alzheimer’s disease[3].

IC50 & Target

SSTR1

 

In Vitro

CH275 (100 nM) activates neprilysin activity, wheras treatment with cyclo-SRIF can complete this activation in vitro in primary neuron-based cell culture system, a mixture of wildtype hippocampal, cortical and striatal neuron[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CH 275 Related Antibodies
In Vivo

CH275 (osmotic pump administration; 56 μM; two weeks) decreases the level of neprilysin/SRIF in the App knock-in mice[3].
CH275 directly injects into the Lacunosum molecular layer (Lmol) layer of 2-month-old AppNL-G-F mice for four months. AppNL-G-F mice begin to exhibit Aβ plaques at two months of age, but CH275 leads to robustly increased the expression of neprilysin in hippocampus which is paralleled by a clear reduction in Aβ plaque load in the same region, and without causing any toxic side effects[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1485.77

Formula

C74H96N14O15S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Lys-Phe-Phe-{d-Trp}-Phe-Thr-Phe-Thr-Ser-Cys (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe)
Sequence Shortening

CKFF-{d-Trp}-XTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (67.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (33.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6731 mL 3.3653 mL 6.7305 mL
5 mM 0.1346 mL 0.6731 mL 1.3461 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.6731 mL 3.3653 mL 6.7305 mL 16.8263 mL
5 mM 0.1346 mL 0.6731 mL 1.3461 mL 3.3653 mL
10 mM 0.0673 mL 0.3365 mL 0.6731 mL 1.6826 mL
15 mM 0.0449 mL 0.2244 mL 0.4487 mL 1.1218 mL
20 mM 0.0337 mL 0.1683 mL 0.3365 mL 0.8413 mL
25 mM 0.0269 mL 0.1346 mL 0.2692 mL 0.6731 mL
30 mM 0.0224 mL 0.1122 mL 0.2244 mL 0.5609 mL
DMSO 40 mM 0.0168 mL 0.0841 mL 0.1683 mL 0.4207 mL
50 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.3365 mL
60 mM 0.0112 mL 0.0561 mL 0.1122 mL 0.2804 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CH 275 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CH 275174688-78-9CH275CH-275Somatostatin ReceptorSSTRsSSTRSst Aβ plaqueneprilysinhippocampalcorticalstriatal neuronAlzheimer’s diseaseInhibitorinhibitorinhibit

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