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Results for "

chronic liver fibrosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (1) Bcl-2 Family (1) Caspase (1) CDK (1) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (1) ERK (1) Ferroptosis (1) Glutathione S-transferase (1) HBV (1) HCV (1) HSP (1) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (1) Microtubule/Tubulin (1) mTOR (1) Necroptosis (1) NF-κB (2) P-glycoprotein (1) p38 MAPK (1) Potassium Channel (1) Reactive Oxygen Species (1) Sirtuin (1) TGF-β Receptor (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (5) Neurological Disease (1)

By Targets:

Apoptosis (2)

Autophagy (1)

Bcl-2 Family (1)

Caspase (1)

CDK (1)

Cyclin G-associated Kinase (GAK) (1)

Cyclophilin (1)

ERK (1)

Ferroptosis (1)

Glutathione S-transferase (1)

HBV (1)

HCV (1)

HSP (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

JNK (1)

Microtubule/Tubulin (1)

mTOR (1)

Necroptosis (1)

NF-κB (2)

P-glycoprotein (1)

p38 MAPK (1)

Potassium Channel (1)

Reactive Oxygen Species (1)

Sirtuin (1)

TGF-β Receptor (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (3)

Cardiovascular Disease (1)

Infection (1)

Inflammation/Immunology (5)

Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: LXR CFTR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0698

Thioacetamide 2 Publications Verification Acetothioamide; TAA; Thiacetamide	Necroptosis	Inflammation/Immunology
Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model .

HY-135644

Rencofilstat CRV431	Cyclophilin Sirtuin	Cancer
Rencofilstat (CRV431) is a pan-cyclophilin inhibitor with IC₅₀ values of 2.5 nM, 3.1 nM, 2.8 nM, 7.3 nM for Cyp A, CypB, Cyp D and Cyp G, respectively. Rencofilstat reduces fibrosis and tumor growth in models of chronic liver disease .

HY-W011641

(±)-Naringenin 3 Publications Verification	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

HY-B0766

Bicyclol SY801	Autophagy Apoptosis HBV HCV HSP Reactive Oxygen Species Bcl-2 Family Glutathione S-transferase p38 MAPK NF-κB Microtubule/Tubulin ERK JNK TNF Receptor Interleukin Related CDK Cyclin G-associated Kinase (GAK) mTOR P-glycoprotein Ferroptosis	Infection Inflammation/Immunology Cancer
Bicyclol (SY801) is an orally active derivative of the traditional Chinese medicine Schisandra chinensis, which has antiviral, anti-inflammatory, immunomodulatory, antioxidant, anti-steatosis, anti-fibrotic and anti-tumor activities. Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Bicyclol can change the expression of Mdr-1, GSH/GST and Bcl-2, increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs. Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the Ras/Raf/MEK/ERK pathway. Bicyclol can be used in the study of chronic hepatitis, acute liver injury, nonalcoholic fatty liver disease, liver fibrosis and hepatocellular carcinoma .

HY-B0149S3

Tranexamic acid-13C2,15N Cyclocapron-¹³C₂,¹⁵N	Isotope-Labeled Compounds	Inflammation/Immunology
Tranexamic acid- ¹³C₂, ¹⁵N (Cyclocapron- ¹³C₂, ¹⁵N) is the ¹³C₂ and ¹⁵N labeled Tranexamic acid. Tranexamic acid is an antifibrinolytic agent that alleviates liver damage and fibrosis in mouse models of chronic bile duct injury .

HY-122179

NUCC-555	TGF-β Receptor	Inflammation/Immunology
NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice .

Cat. No.	Product Name

HY-L185

Anti-Fibrosis Compound Library	1,805 compounds
Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening. MCE contains 1,805 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Anti-Fibrosis Compound Library

1,805 compounds

Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening.

MCE contains 1,805 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011641

(±)-Naringenin 3 Publications Verification	Cardiovascular Disease Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

Cat. No.	Product Name	Chemical Structure

HY-B0149S3

Tranexamic acid-13C2,15N
Tranexamic acid- ¹³C₂, ¹⁵N (Cyclocapron- ¹³C₂, ¹⁵N) is the ¹³C₂ and ¹⁵N labeled Tranexamic acid. Tranexamic acid is an antifibrinolytic agent that alleviates liver damage and fibrosis in mouse models of chronic bile duct injury .

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