Search Result

Results for "

dioxygenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HPPD (6) Indoleamine 2,3-Dioxygenase (IDO) (39) Apoptosis (5) ATP Synthase (2) Aurora Kinase (4) Bacterial (4) Endogenous Metabolite (11) Histone Demethylase (5) mAChR (4) Methionine Adenosyltransferase (MAT) (1) Molecular Glues (1) mTOR (2) Parasite (4) PROTACs (2) Reactive Oxygen Species (6) Sirtuin (1) Virus Protease (4)
By Research Areas:	Cancer (44) Infection (14) Inflammation/Immunology (12) Metabolic Disease (8) Neurological Disease (10)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Indoleamine 2,3-Dioxygenase (IDO) HPPD TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2915

Protocatechuate 3,4-dioxygenase	Others	Others
Protocatechuate 3,4-dioxygenase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Histone Demethylase Endogenous Metabolite	Cancer
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Histone Demethylase Endogenous Metabolite	Cancer
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-P2976

Lipoxygenase, general LOX	Endogenous Metabolite	Others
Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid .

HY-144900

Topramezone	Reactive Oxygen Species	Others
Topramezone is a potent 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide, used for the post-emergence control of broadleaf and grass weeds in corn .

HY-128355

IDO/TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and *tryptophan 2,3-dioxygenase* (TDO) inhibitor with IC₅₀**s of 9.7 and 47 nM, respectively .

HY-33298

LM10	Others	Cancer
LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases .

HY-15683

IDO5L 3 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 67 nM.

HY-133597

4-Chlorocatechol	Others	Others
4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP). 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase .

HY-144900R

Topramezone (Standard)	Reactive Oxygen Species	Others
Topramezone (Standard) is the analytical standard of Topramezone. This product is intended for research and analytical applications. Topramezone is a potent 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor. Topramezone is a herbicide, used for the post-emergence control of broadleaf and grass weeds in corn .

HY-W016584

4,5-Dichlorocatechol	Others	Infection
4,5-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71. The K_i values for 4,5-dichlorocatechol is 30 nM for the dioxygenase of the Chlorobenzoate-degrading strain Pseudomonas putida AC27 and 4 nM for the dioxygenase of Acidovorax sp. strain PS14 .

HY-16987

IDO-IN-3	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 290 nM.

HY-79531

IDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC₅₀ of 59 nM.

HY-145346

NLG802	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
NLG802 is a proagent of indoximod, an orally active *indoleamine 2,3-dioxygenase* (IDO)** inhibitor.

HY-D0033

Roxyl-9	Indoleamine 2,3-Dioxygenase (IDO)	Others
Roxyl-9 is a IDO1 (Indoleamine 2,3-dioxygenase 1) inhibitor .

HY-W012814

4-Methylcatechol	Endogenous Metabolite	Others
4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase.

HY-151425

TDO-IN-1	Others	Cancer
TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over *indoleamine-2,3-dioxygenase* (IDO), with an IC₅₀ value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo .

HY-115122

IDO-IN-12	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1.

HY-133609

3,5-Dichlorocatechol	Others	Infection
3,5-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71 .

HY-133611

3,4-Dichlorocatechol	Others	Infection
3,4-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71 .

HY-133612

3,6-Dichlorocatechol	Others	Infection
3,6-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71 .

HY-151886

NU223612	PROTACs Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Cancer
NU223612 is a potent PROTAC (PROTACs) that degrades *indoleamine 2,3-dioxygenase* 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a K_d of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN**-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB) .

HY-18770B

Navoximod 5+ Cited Publications GDC-0919; NLG-919	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Navoximod (GDC-0919; NLG-919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with K_i/EC₅₀ of 7 nM/75 nM.

HY-129749

IDO-IN-13	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
IDO-IN-13 is a potent *indoleamine 2,3-dioxygenase* 1 (IDO1) inhibitor with an EC₅₀** of 17 nM, extracted from patent WO2019040102A1, example 43 .

HY-148383

DP00477	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
DP00477 is a potent *IDO1 (indoleamine 2,3-dioxygenase* 1) inhibitor with an IC₅₀** value of 7.0 µM. DP00477 has the potential for the research of cancer .

HY-139204

BMS-986242 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer .

HY-18769

BMS-978587 1 Publications Verification IDO-IN-4	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

HY-18770A

IDO-IN-6 NLG-1486	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, Compound 1486, has an IC₅₀ of <1 μM.

HY-18770

IDO-IN-5 NLG-1489	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC₅₀ of 1-10 μM.

HY-100687

GNF-PF-3777 8-Nitrotryptanthrin	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with K_i of 0.97 μM.

HY-N0707

(S)-Indoximod 1-Methyl-L-tryptophan; (S)-NLG-8189	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Cancer
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of *indoleamine 2,3-dioxygenase* (IDO) (K_i**: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease .

HY-18770C

IDO-IN-8 NLG-1487	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC₅₀ of 1-10 μM.

HY-N12125

Entadamide A	Others	Infection
Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

HY-P4149

Imsamotide IDO194-214	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Imsamotide (IDO194-214) is a *Indoleamine 2,3-Dioxygenase* (IDO)** peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent .

HY-135767

Bicyclopyrone	Others	Metabolic Disease
Bicyclopyrone is an inhibitor of *4-hydroxyphenylpyruvate dioxygenase* (Hpd)** .

HY-16724

Indoximod 5+ Cited Publications 1-Methyl-D-tryptophan; NLG-8189	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer .

HY-W012814S

4-Methylcatechol-d3	Endogenous Metabolite	Others
4-Methylcatechol-d₃ is the deuterium labeled 4-Methylcatechol[1]. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase[2].

HY-W012814S1

4-Methylcatechol-d8	Endogenous Metabolite	Others
4-Methylcatechol-d₈ is the deuterium labeled 4-Methylcatechol[1]. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase[2].

HY-W012814S2

4-Methylcatechol-d6	Endogenous Metabolite	Others
4-Methylcatechol-d₆ is the deuterium labeled 4-Methylcatechol[1]. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase[2].

HY-N2463

Kushenol E	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive *indoleamine 2,3-dioxygenase* 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i** of 9.5 µM, has anti-tumor activity .

HY-151093

IDO2-IN-1 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
IDO2-IN-1 is an orally active and potent *Indoleamine 2,3-dioxygenase* 2 (IDO2) inhibitor with an IC₅₀** value of 112 nM. IDO2-IN-1 can be used for inflammatory autoimmunity research .

HY-W025799

N-Benzylideneaniline N-Benzalaniline; N-Phenylbenzylimine	Histone Demethylase	Cancer
N-Benzylideneaniline is an inhibitor of xylinostilbene-α,β-dioxygenase (LSD) .

HY-111234

IDO-IN-11	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC₅₀s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 13.

HY-110387

IDO-IN-9	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC₅₀s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6.

HY-N0707S

(S)-Indoximod-d3 1-Methyl-L-tryptophan-d₃; (S)-NLG-8189-d₃	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(S)-Indoximod-d₃ is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].

HY-108681

680C91 1 Publications Verification	Others	Neurological Disease Inflammation/Immunology Cancer
680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a K_i of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease .

HY-107368

Sulcotrione	Reactive Oxygen Species	Others
Sulcotrione is a β-triketone herbicide which can inhibit hydroxyphenylpyruvate dioxygenase (HPPD).

HY-101560

Linrodostat 4 Publications Verification BMS-986205; ONO-7701	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) is a selective and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO1) inhibitor with an IC₅₀ value of 1.1 nM in IDO1**-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers .

HY-161348

AT-0174	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
AT-0174 is an orally active dual inhibitor of IDO1/TDO2 (tryptophan 2,3-dioxygenase-2) with IC₅₀ values of 0.17 and 0.25 μM, respectively. AT-0174 has antitumor activity .

HY-108331

3-TYP Maximum Cited Publications 60 Publications Verification	Sirtuin Methionine Adenosyltransferase (MAT) Indoleamine 2,3-Dioxygenase (IDO)	Others
3-TYP is an inhibitor of SIRT3 (IC₅₀: ~377 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases .

Cat. No.	Product Name	Target	Research Area

HY-P4149

Imsamotide IDO194-214	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Imsamotide (IDO194-214) is a *Indoleamine 2,3-Dioxygenase* (IDO)** peptide with sequences of DTLLKALLEIASCLEKALQVF, the IDO194-214. Imsamotide is also an immunological agent for active immunization, as well as an antineoplastic agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-W012814

4-Methylcatechol	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase.

HY-N0707

(S)-Indoximod 1-Methyl-L-tryptophan; (S)-NLG-8189	Structural Classification Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Abrus precatorius Linn. Plants Disease Research Fields Cancer	Indoleamine 2,3-Dioxygenase (IDO)
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of *indoleamine 2,3-dioxygenase* (IDO) (K_i**: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease .

HY-N12125

Entadamide A	Structural Classification Natural Products Petasites formosanus Kitam. Leguminosae Source classification Plants	Others
Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

HY-N2463

Kushenol E	Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Moghania philippinensis (Merr. Et Rolfe) L. Plants Disease Research Fields Cancer	Indoleamine 2,3-Dioxygenase (IDO)
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive *indoleamine 2,3-dioxygenase* 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i** of 9.5 µM, has anti-tumor activity .

HY-128355A

(R)-IDO/TDO-IN-1	Classification of Application Fields Disease Research Fields Cancer	Indoleamine 2,3-Dioxygenase (IDO)
(R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties. (R)-IDO/TDO-IN-1 exhibits anti-tumor activity in MC38 xenograft model. (R)-IDO/TDO-IN-1 shows synergistic effect with anti-PD-1 monoclonal antibody (SHR-1210) .

HY-N0110

Palmatine chloride Maximum Cited Publications 6 Publications Verification	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine chloride is an orally active and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀** of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-116620

Benzomalvin C	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC₅₀ value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

HY-114991

Leptospermone	Leptospermum scoparium J. R. Forst. et G. Forst. Structural Classification Natural Products Source classification Myrtaceae Plants	HPPD
Leptospermone is a competitive, reversible inhibitor for p-Hydroxyphenylpyruvate dioxygenase (HPPD), with an IC₅₀ of 12.1 μM. Leptospermone exhibits herbicidal activity for its bleaching effect .

HY-N0110A

Palmatine	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine is an orally active and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀** of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110B

Palmatine hydroxide Maximum Cited Publications 6 Publications Verification	Alkaloids Phellodendron amurense Rupr. Other Alkaloids Source classification Rutaceae Plants	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine hydroxide is an orally active and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀** of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110R

Palmatine chloride (Standard)	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible *indoleamine 2,3-dioxygenase* 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀** of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N12196

Terretonin	Structural Classification Other Monoterpenes Microorganisms Terpenoids Source classification	Others
Terretonin is a fungal terpenoid isolated from Aspergillus terreus. The complete biosynthetic pathway of terretonin includes: cytochrome P450 Trt6 catalyzes the oxidation of terrenoid to obtain an unstable intermediate; then it is catalyzed by isomerase Trt14 and processed by non-heme iron-dependent dioxygenase Trt7 to complete the biosynthesis of terretonin .

HY-N11854

Brassicanate A sulfoxide	Structural Classification Alkaloids Pyrrole Alkaloids Brassica oleracea L. Source classification Plants Brassicaceae	Others
Brassicanate A sulfoxide has herbicidal activity. Brassicanate A sulfoxide inhibits the biosynthesis of essential amino acids in plants. Brassicanate A sulfoxide binds to dihydroxyacid dehydratase (DHAD), hydroxymethylpyruvate dioxygenase (HPPD), acetolactate synthase (ALS), PYL family proteins and transport inhibitor response 1 (TIR1), and reduces their activity. Brassicanate A sulfoxide can be isolated from Brassica oleracea .

HY-113038

D-α-Hydroxyglutaric acid (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Classification of Application Fields Neurological Disease Anti-aging Source classification Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases *reactive oxygen* species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR** signaling .

HY-100542

D-α-Hydroxyglutaric acid disodium 3 Publications Verification Disodium (R)-2-hydroxyglutarate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases *reactive oxygen* species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR** signaling .

Species:	Human (13) Mouse (1) Rat (1) E.coli (1)
Tag:	His (16) SUMO (2) Tag Free (5) Myc (1) GST (2) Flag (2) CL7 (1)
Source:	P. pastoris (1) Sf9 insect cells (2) E. coli (18)

Cat. No.	Compare	Product Name	Species	Source

HY-P72616

	IDO Protein, Mouse (His) Indoleamine 2,3-dioxygenase 1; IDO-1; Indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO	Mouse	E. coli
	IDO Protein, an enzyme, is involved in the metabolism of tryptophan. Dysregulation of IDO Protein has been linked to immune escape mechanisms and tumor progression. Targeting IDO Protein may provide potential therapeutic interventions in cancer by modulating tryptophan metabolism, enhancing immune responses, and inhibiting tumor growth. IDO Protein, Mouse (His) is the recombinant mouse-derived IDO protein, expressed by E. coli , with N-6*His labeled tag. The total length of IDO Protein, Mouse (His) is 407 a.a., with molecular weight of 40-50 kDa.

HY-P76324

	ETHE1 Protein, Human (His) Persulfide dioxygenase ETHE1; Sulfur dioxygenase ETHE1; HSCO	Human	E. coli
	The ETHE1 protein is an important sulfur dioxygenase that plays an integral role in mitochondrial hydrogen sulfide catabolism.It cooperates with SQRDL to oxidize cysteine persulfide residues formed from hydrogen sulfide (H2S), preventing the accumulation of toxic H2S and maintaining metabolic homeostasis.ETHE1 Protein, Human (His) is the recombinant human-derived ETHE1 protein, expressed by E.coli , with N-His labeled tag.

HY-P70066

	*CDO1/Cysteine dioxygenase* type 1 Protein, Human (His)** 1 Publications Verification rHuCysteine dioxygenase type 1/CDO1, His; Cysteine dioxygenase Type 1; Cysteine dioxygenase Type I; CDO; CDO-I; CDO1	Human	E. coli
	Cysteine dioxygenase (CDO1) plays a crucial role in cellular metabolism by catalyzing the oxidation of cysteine to cysteine sulfenic acid, a key step involving the addition of molecular dioxygen . This enzymatic process underlies cysteine catabolism and helps regulate sulfur amino acid metabolism. CDO1/Cysteine dioxygenase type 1 Protein, Human (His) is the recombinant human-derived CDO1/Cysteine dioxygenase type 1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDO1/Cysteine dioxygenase type 1 Protein, Human (His) is 200 a.a., with molecular weight of 20-28 kDa.

HY-P70679

	IDO Protein, Human (His) Indole 2; 3-dioxygenase; Indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO	Human	E. coli
	IDO proteins catalyze the first step in tryptophan catabolism via the kynurenine pathway, which is critical for immune tolerance and homeostasis maintenance. IDO Protein, Human (His) is the recombinant human-derived IDO protein, expressed by E. coli , with N-6*His labeled tag. The total length of IDO Protein, Human (His) is 403 a.a., with molecular weight of 40-50 kDa.

HY-P70863

	IDO-2 Protein, Human (His) Indoleamine 2,3-dioxygenase 2; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine pyrrole 2,3-dioxygenase-like protein 1; IDO2; INDOL1	Human	E. coli
	The IDO-2 protein plays a key role in cellular processes, catalyzing the initial and rate-limiting steps in the catabolism of the essential amino acid tryptophan in the kynurenine pathway. This enzymatic activity has been confirmed in multiple studies, establishing IDO-2 as a key regulator of tryptophan metabolism with important implications for immune regulation. IDO-2 Protein, Human (His) is the recombinant human-derived IDO-2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of IDO-2 Protein, Human (His) is 407 a.a., with molecular weight of ~41.43 kDa.

HY-P70024

	HPD/HPPDase Protein, Human (His) rHu4-hydroxyphenylpyruvate dioxygenase /HPD, His; 4-Hydroxyphenylpyruvate dioxygenase; 4-Hydroxyphenylpyruvic Acid Oxidase; 4HPPD; HPD; HPPDase; HPD; PPD	Human	E. coli
	HPD is a key enzyme in tyrosine catabolism and plays a key role in catalyzing the conversion of 4-hydroxyphenylpyruvate into homogentisate. This enzymatic process represents a key step in the tyrosine metabolic pathway and contributes to the breakdown of this amino acid. HPD/HPPDase Protein, Human (His) is the recombinant human-derived HPD/HPPDase protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71743

	IDO-2 Protein, Human (P.pastoris, His) 3-dioxygenase 2; Indoleamine-pyrrole 2	Human	P. pastoris
	The IDO-2 protein plays a key role in cellular processes, catalyzing the initial and rate-limiting steps in the catabolism of the essential amino acid tryptophan in the kynurenine pathway. This enzymatic activity has been confirmed in multiple studies, establishing IDO-2 as a key regulator of tryptophan metabolism with important implications for immune regulation. IDO-2 Protein, Human (P.pastoris, His) is the recombinant human-derived IDO-2 protein, expressed by P. pastoris , with N-His labeled tag. The total length of IDO-2 Protein, Human (P.pastoris, His) is 407 a.a., with molecular weight of ~50.4 kDa.

HY-P73121

	IDO Protein, Human Indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO	Human	E. coli
	IDO proteins catalyze the first step in tryptophan catabolism via the kynurenine pathway, which is critical for immune tolerance and homeostasis maintenance. IDO Protein, Human is the recombinant human-derived IDO protein, expressed by E. coli , with tag free.

HY-P702105

	*Phytanoyl-CoA dioxygenase* Protein, Actinophytocola oryzae** Ectoine hydroxylase	Others	E. coli
	Phytyl-CoA dioxygenase (PHYH) is an enzyme involved in the alpha-oxidation of phytanic acid, a branched-chain fatty acid. PHYH catalyzes the conversion of phytyl-CoA to 2-hydroxyphytyl-CoA, initiating the degradation pathway. Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae is the recombinant Phytanoyl-CoA dioxygenase protein, expressed by E. coli , with tag free. The total length of Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae is 266 a.a., .

HY-P702106

	*Phytanoyl-CoA dioxygenase* Protein, Actinophytocola oryzae (His)** Ectoine hydroxylase	Others	E. coli
	Phytyl-CoA dioxygenase (PHYH) is an enzyme involved in the alpha-oxidation of phytanic acid, a branched-chain fatty acid. PHYH catalyzes the conversion of phytyl-CoA to 2-hydroxyphytyl-CoA, initiating the degradation pathway. Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae (His) is the recombinant Phytanoyl-CoA dioxygenase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Phytanoyl-CoA dioxygenase Protein, Actinophytocola oryzae (His) is 266 a.a., .

HY-P76544

	PHYH Protein, Human Phytanoyl-CoA dioxygenase, peroxisomal; Phytanic acid oxidase; PhyH; PAHX	Human	E. coli
	PHYH protein catalyzes 2-hydroxylation of various mono-branched and straight-chain acyl-CoA esters, including racemic phytanoyl-CoA and isomers of 3-methylhexadecanoyl-CoA. It acts on acyl-CoAs with a chain length of at least seven carbon atoms, excluding long, very long straight-chain, and 2-methyl or 4-methyl-branched acyl-CoAs. PHYH Protein, Human is the recombinant human-derived PHYH protein, expressed by E. coli , with tag free. The total length of PHYH Protein, Human is 308 a.a., with molecular weight of 32 kDa.

HY-P76963

	HAAO Protein, Rat (His) 3-hydroxyanthranilate 3,4-dioxygenase; 3-HAO; HAD	Rat	E. coli
	HAAO Protein, an enzyme, is involved in the metabolism of tryptophan and the production of quinolinic acid. Dysregulation of HAAO Protein has been associated with neurodegenerative diseases and psychiatric disorders. HAAO Protein, Rat (His) is the recombinant rat-derived HAAO protein, expressed by E. coli , with N-His labeled tag. The total length of HAAO Protein, Rat (His) is 286 a.a., with molecular weight of ~34.8 KDa.

HY-P702162

	ido Protein, Bacillus thuringiensis ido; L-isoleucine-4-hydroxylase; L-isoleucine dioxygenase; IDO	Others	E. coli
	IDO Protein, an enzyme, is involved in the conversion of tryptophan to kynurenine. Dysregulation of IDO Protein has been associated with immune suppression and tumor development. Targeting IDO Protein may present potential therapeutic approaches in cancer by modulating tryptophan metabolism, restoring immune responses, and inhibiting tumor growth. ido Protein, Bacillus thuringiensis is the recombinant ido protein, expressed by E. coli , with tag free. The total length of ido Protein, Bacillus thuringiensis is 240 a.a., .

HY-P76962

	HAAO Protein, Human (sf9, His-GST) 3-hydroxyanthranilate 3,4-dioxygenase; 3-HAO; HAD	Human	Sf9 insect cells
	HAAO proteins play a key role in cellular metabolism, catalyzing the oxidative ring-opening of 3-hydroxyanthranilic acid.This leads to the formation of 2-amino-3-carboxymuconic acid semialdehyde, which spontaneously cyclizes to quinolinic acid.HAAO Protein, Human (sf9, His-GST) is the recombinant human-derived HAAO protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

HY-P702163

	ido Protein, Bacillus thuringiensis (FLAG, His) ido; L-isoleucine-4-hydroxylase; L-isoleucine dioxygenase; IDO	Others	E. coli
	IDO Protein, an enzyme, is involved in the conversion of tryptophan to kynurenine. Dysregulation of IDO Protein has been associated with immune suppression and tumor development. Targeting IDO Protein may present potential therapeutic approaches in cancer by modulating tryptophan metabolism, restoring immune responses, and inhibiting tumor growth. ido Protein, Bacillus thuringiensis (FLAG, His) is the recombinant ido protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of ido Protein, Bacillus thuringiensis (FLAG, His) is 240 a.a., .

HY-P76163

	BBOX1 Protein, Human (sf9, His-GST) Gamma-butyrobetaine dioxygenase; Gamma-BBH; BBH; BBOX	Human	Sf9 insect cells
	The BBOX1 protein plays a central role in cellular processes as it catalyzes the formation of L-carnitine from gamma-butybetaine. This enzyme activity is essential for the biosynthesis of L-carnitine, an important compound involved in fatty acid metabolism and energy production. BBOX1 Protein, Human (sf9, His-GST) is the recombinant human-derived BBOX1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of BBOX1 Protein, Human (sf9, His-GST) is 387 a.a., with molecular weight of ~65 KDa.

HY-P702161

	Hyoscyamine 6 beta-hydroxylase Protein, Hyoscyamus niger H6H; Hyoscyamine 6-dioxygenase; Hyoscyamine 6-beta-hydroxylase	Others	E. coli
	Hyoscyamine 6 beta-hydroxylase Protein, Hyoscyamus niger is the recombinant Hyoscyamine 6 beta-hydroxylase protein, expressed by E. coli , with tag free. The total length of Hyoscyamine 6 beta-hydroxylase Protein, Hyoscyamus niger is 344 a.a., .

HY-P703511

	lipoxygenase Protein, Human (Flag, His, CL7) Linoleate 9/13-lipoxygenase; Oleate 10S-lipoxygenase; 1.13.11.77; lox; Pseudomonas aeruginosa; dioxygenase; Oxidoreductase; 1.13.11.12	Human	E. coli
	The lipoxygenase protein catalyzes the oxygen-mediated conversion of linoleic acid to 9HPOD and spontaneously decomposes it into 9HOD. It converts linolenic acid into 13HPOD, which breaks down into 13HOD. lipoxygenase Protein, Human (Flag, His, CL7) is the recombinant human-derived lipoxygenase, expressed by E. coli , with CL7, His, Flag labeled tag. ,

HY-P72092

	ASPH Protein, Human (His-SUMO) ASPH; BAHAspartyl/asparaginyl beta-hydroxylase; EC 1.14.11.16; Aspartate beta-hydroxylase; ASP beta-hydroxylase; Peptide-aspartate beta-dioxygenase	Human	E. coli
	ASPH protein phosphorylates SPRTN, facilitating its chromatin recruitment and decreasing replication stress. ASPH activates the G2/M checkpoint by phosphorylating and inhibiting PABIR1/FAM122A, leading to serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity. ASPH Protein, Human (His-SUMO) is the recombinant human-derived ASPH protein, expressed by E. coli, with N-6*His, N-SUMO labeled tag. The total length of ASPH Protein, Human (His-SUMO) is 196 a.a., with molecular weight of ~38.2 kDa.

HY-P71479

	AlkB Protein, E.coli (Myc, His-SUMO) alkB; aidD; b2212; JW2200Alpha-ketoglutarate-dependent dioxygenase AlkB; EC 1.14.11.33; Alkylated DNA repair protein AlkB; DNA oxidative demethylase AlkB	E.coli	E. coli
	AlkB Protein, E.coli (Myc, His-SUMO) is a protein found in E. coli, plays a major role in oxidative dealkylation processes.

HY-P701888

	FTO Protein, Human (His) FTO; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; m6A(m)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; tRNA N1-methyl adenine demethylase FTO	Human	E. coli
	FTO protein is an RNA demethylase that regulates fat mass, lipogenesis, and energy homeostasis by targeting N(6)-methyladenosine in mRNA. It also demethylates m6A in U6 snRNA and m6A(m) in 5'-cap, affecting mRNA stability. FTO Protein, Human (His) is the recombinant human-derived FTO protein, expressed by E. coli , with N-6*His labeled tag. The total length of FTO Protein, Human (His) is 474 a.a., .

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Cat. No.	Product Name	Chemical Structure

HY-W012814S2

4-Methylcatechol-d6
4-Methylcatechol-d₆ is the deuterium labeled 4-Methylcatechol[1]. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase[2].

HY-N0707S

(S)-Indoximod-d3
(S)-Indoximod-d₃ is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].

HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium

α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

HY-113038AS1

α-Hydroxyglutaric acid-d4 disodium

α-Hydroxyglutaric acid-d₄ (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

HY-W012814S

4-Methylcatechol-d3
4-Methylcatechol-d₃ is the deuterium labeled 4-Methylcatechol[1]. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase[2].

HY-W012814S1

4-Methylcatechol-d8
4-Methylcatechol-d₈ is the deuterium labeled 4-Methylcatechol[1]. 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase[2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83355

	*Indoleamine 2,3-dioxygenase* Antibody (YA3100)** 3-dioxygenase; IDO 1; IDO; IDO1; INDO; indolamine 2; 3 dioxygenase; Indole 2 3 dioxygenase	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Indoleamine 2,3-dioxygenase Antibody (YA3100) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3100), targeting Indoleamine 2,3-dioxygenase, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). Indoleamine 2,3-dioxygenase Antibody (YA3100) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

HY-P83297

	HPDL Antibody (YA3042) 4-hydroxyphenylpyruvate dioxygenase like; GLOXD1; 4-HPPD-L	WB, IP	Human
	HPDL Antibody (YA3042) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3042), targeting HPDL, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). HPDL Antibody (YA3042) can be used for WB, IP experiment in human background.

HY-P80680

	FTO Antibody FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein	WB, IHC-P	Human
	FTO Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 58 kDa, targeting to FTO. It can be used for WB,IHC-P assays with tag free, in the background of Human.