HPPD

4-Hydroxyphenylpyruvate dioxygenase

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an Fe(II)-dependent, non-heme oxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. HPPD catalyzes the second step in the pathway for the catabolism of tyrosine, that is common to essentially all aerobic forms of life. In plants this pathway has an anabolic branch from homogentisate that forms essential isoprenoid redox cofactors such as plastoquinone and tocopherol.he transformation catalyzed by HPPD has both agricultural and therapeutic significance

HPPD Inhibitors (5)

HPPD Related Products (10):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0607

Nitisinone		99.83%
Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism.

HY-118742

Benzobicyclon		99.25%
Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds.

HY-B0607R

Nitisinone (Standard)
Nitisinone (Standard) is the analytical standard of Nitisinone. This product is intended for research and analytical applications. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism.

HY-155135

HPPD-IN-1	Inhibitor
HPPD-IN-1 (compound II-3) is a HPPD inhibitor. HPPD-IN-1 shows inhibitory activity of Arabidopsis thaliana HPPD (AtHPPD) with an IC₅₀ value of 0.248 μM, which was superior to that of mesotrione (HY-12853) (0.283 μM) in vitro. HPPD-IN-1 shows excellent herbicidal activity against broadleaf and monocotyledonous weeds.

HY-111957

Fenquinotrione
Fenquinotrione is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor with IC₅₀s of 27.2 and 44.7nM against rice and Arabidopsis thaliana HPPD, respectively. Fenquinotrione is an herbicide that can control a wide range of broadleaf and sedge weeds with excellent rice selectivity.

HY-114991

Leptospermone	Inhibitor
Leptospermone is a competitive, reversible inhibitor for p-Hydroxyphenylpyruvate dioxygenase (HPPD), with an IC₅₀ of 12.1 μM. Leptospermone exhibits herbicidal activity for its bleaching effect.

HY-163559

HPPD-IN-4	Inhibitor
HPPD-IN-4 (Compound III-29) is a selective inhibitor of HPPD with anIC₅₀ of 0.19 μM. HPPD-IN-4 is primarily used in the study of high-efficiency herbicides.

HY-161308

HPPD-IN-3	Inhibitor
HPPD-IN-3 (compound 25) is a potent inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD), with IC50 of 10 nM, more potency than Mesotrione (HY-12853).

HY-155465

HPPD-IN-2	Inhibitor
HPPD-IN-2 (compound 28) is a herbicide based on HPPD inhibitors. HPPD-IN-2 potently targets AtHPPD and exhibits enhanced safety in canola crops.

HY-118742R

Benzobicyclon (Standard)
Benzobicyclon (Standard) is the analytical standard of Benzobicyclon. This product is intended for research and analytical applications. Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds.

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