2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO-IN-8

IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.

For research use only. We do not sell to patients.

IDO-IN-8 Chemical Structure

IDO-IN-8 Chemical Structure

CAS No. : 1402837-77-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in Ethanol USD 990 In-stock
Solid
1 mg USD 360 In-stock
5 mg USD 900 In-stock
10 mg USD 1440 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of IDO-IN-8:

IDO-IN-8 Related Antibodies

Top Publications Citing Use of Products

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

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IDO1 IDO2 IDO

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.

IC50 & Target[1]

IDO

1-10 μM (IC50)

In Vitro

IDO-IN-8 (Compound 1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 1-10 μM (this is the concentration of IDO-IN-8 at which inhibits 50% of enzymatic activity using recombinant human IDO)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDO-IN-8 Related Antibodies
Molecular Weight

316.37

Formula

C18H21FN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H](CC1)CC[C@]1([H])[C@@H](O)C[C@H]2N3C(C4=C2C(F)=CC=C4)=CN=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (316.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1609 mL 15.8043 mL 31.6086 mL
5 mM 0.6322 mL 3.1609 mL 6.3217 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.1609 mL 15.8043 mL 31.6086 mL 79.0214 mL
5 mM 0.6322 mL 3.1609 mL 6.3217 mL 15.8043 mL
10 mM 0.3161 mL 1.5804 mL 3.1609 mL 7.9021 mL
15 mM 0.2107 mL 1.0536 mL 2.1072 mL 5.2681 mL
20 mM 0.1580 mL 0.7902 mL 1.5804 mL 3.9511 mL
25 mM 0.1264 mL 0.6322 mL 1.2643 mL 3.1609 mL
30 mM 0.1054 mL 0.5268 mL 1.0536 mL 2.6340 mL
40 mM 0.0790 mL 0.3951 mL 0.7902 mL 1.9755 mL
50 mM 0.0632 mL 0.3161 mL 0.6322 mL 1.5804 mL
60 mM 0.0527 mL 0.2634 mL 0.5268 mL 1.3170 mL
80 mM 0.0395 mL 0.1976 mL 0.3951 mL 0.9878 mL
100 mM 0.0316 mL 0.1580 mL 0.3161 mL 0.7902 mL
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IDO-IN-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO-IN-81402837-77-7NLG-1487NLG1487NLG 1487Indoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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