2. Metabolic Enzyme/Protease
  3. HPPD
  4. Leptospermone

Leptospermone is a competitive, reversible inhibitor for p-Hydroxyphenylpyruvate dioxygenase (HPPD), with an IC50 of 12.

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Leptospermone Chemical Structure

Leptospermone Chemical Structure

CAS No. : 567-75-9

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Leptospermone Related Antibodies

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Description

Leptospermone is a competitive, reversible inhibitor for p-Hydroxyphenylpyruvate dioxygenase (HPPD), with an IC50 of 12.1 μM. Leptospermone exhibits herbicidal activity for its bleaching effect[1]. IC50 & Target:IC50: 12.1 μM (HPPD)

Molecular Weight

266.33

Formula

C15H22O4
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C1C(C)(C(C(C)(C(C1C(CC(C)C)=O)=O)C)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (375.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7547 mL 18.7737 mL 37.5474 mL
5 mM 0.7509 mL 3.7547 mL 7.5095 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7547 mL 18.7737 mL 37.5474 mL 93.8685 mL
5 mM 0.7509 mL 3.7547 mL 7.5095 mL 18.7737 mL
10 mM 0.3755 mL 1.8774 mL 3.7547 mL 9.3869 mL
15 mM 0.2503 mL 1.2516 mL 2.5032 mL 6.2579 mL
20 mM 0.1877 mL 0.9387 mL 1.8774 mL 4.6934 mL
25 mM 0.1502 mL 0.7509 mL 1.5019 mL 3.7547 mL
30 mM 0.1252 mL 0.6258 mL 1.2516 mL 3.1290 mL
40 mM 0.0939 mL 0.4693 mL 0.9387 mL 2.3467 mL
50 mM 0.0751 mL 0.3755 mL 0.7509 mL 1.8774 mL
60 mM 0.0626 mL 0.3129 mL 0.6258 mL 1.5645 mL
80 mM 0.0469 mL 0.2347 mL 0.4693 mL 1.1734 mL
100 mM 0.0375 mL 0.1877 mL 0.3755 mL 0.9387 mL
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Leptospermone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leptospermone567-75-9HPPD4-Hydroxyphenylpyruvate dioxygenasecompetitivereversibleLeptospermum scopariummanukaInhibitorinhibitorinhibit

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