BMS-978587 (Synonyms: IDO-IN-4)

Name: BMS-978587
Brand: MedChemExpress
SKU: HY-18769
Rating: 4.5 (1 reviews)

Cat. No.: HY-18769 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

For research use only. We do not sell to patients.

BMS-978587 Chemical Structure

CAS No. : 1629125-65-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 319	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 319	In-stock	Estimated Time of Arrival: December 31
Solid
2 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 435	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 830	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1880	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE BMS-978587

•Patent. US20190382356A1.

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IDO1 IDO2 IDO

Biological Activity
Purity & Documentation
References
Customer Review

Description

BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

IC₅₀ & Target^[1]

IDO-1

In Vitro

BMS-978587 (IDO-IN-4) (Compound example 1 enantiomer 1) is a IDO-1 inhibitor in human IDO1/HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

437.57

Formula

C₂₆H₃₅N₃O₃

CAS No.

1629125-65-0

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(NC1=CC=C(C)C=C1)NC2=CC([C@@H](C3)[C@@H]3C(O)=O)=CC=C2N(CC(C)C)CC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (228.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2853 mL	11.4267 mL	22.8535 mL
5 mM	0.4571 mL	2.2853 mL	4.5707 mL
10 mM	0.2285 mL	1.1427 mL	2.2853 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Balog, et al. Preparation of cycloalkylaryl amide compounds as indoleamine 2,3-dioxygenase and therapeutic uses thereof. From PCT Int. Appl. (2014), WO 2014150677 A1 20140925.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2853 mL	11.4267 mL	22.8535 mL	57.1337 mL
	5 mM	0.4571 mL	2.2853 mL	4.5707 mL	11.4267 mL
	10 mM	0.2285 mL	1.1427 mL	2.2853 mL	5.7134 mL
	15 mM	0.1524 mL	0.7618 mL	1.5236 mL	3.8089 mL
	20 mM	0.1143 mL	0.5713 mL	1.1427 mL	2.8567 mL
	25 mM	0.0914 mL	0.4571 mL	0.9141 mL	2.2853 mL
	30 mM	0.0762 mL	0.3809 mL	0.7618 mL	1.9045 mL
	40 mM	0.0571 mL	0.2857 mL	0.5713 mL	1.4283 mL
	50 mM	0.0457 mL	0.2285 mL	0.4571 mL	1.1427 mL
	60 mM	0.0381 mL	0.1904 mL	0.3809 mL	0.9522 mL
	80 mM	0.0286 mL	0.1428 mL	0.2857 mL	0.7142 mL
	100 mM	0.0229 mL	0.1143 mL	0.2285 mL	0.5713 mL

BMS-978587 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9785871629125-65-0IDO-IN-4BMS978587BMS 978587Indoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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BMS-978587 (Synonyms: IDO-IN-4)

Customer Review

BMS-978587 Related Antibodies

1 Publications Citing Use of MCE BMS-978587

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

BMS-978587 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

BMS-978587 Related Classifications

Keywords:

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Customer Review

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