2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO-IN-3

IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM.

For research use only. We do not sell to patients.

IDO-IN-3 Chemical Structure

IDO-IN-3 Chemical Structure

CAS No. : 2070018-30-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 341 In-stock
Solution
10 mM * 1 mL in DMSO USD 341 In-stock
Solid
2 mg USD 210 In-stock
5 mg USD 310 In-stock
10 mg USD 530 In-stock
50 mg USD 1650 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

IDO-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

View All Isoforms
IDO1 IDO2 IDO

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM.

IC50 & Target[1]

IDO

290 nM (IC50)

IDO

98 nM (IC50, in HeLa cell)

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
98 nM
Compound: 4c
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
[PMID: 28523098]
In Vitro

IDO-IN-3 (Compound 4c) is a potent (HeLa IC50=98 nM) inhibitor of IDO[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDO-IN-3 Related Antibodies
Molecular Weight

359.15

Formula

C11H12BrFN6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O/N=C(NC1=CC(Br)=C(F)C=C1)\C2=NON=C2NCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 27.5 mg/mL (76.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7844 mL 13.9218 mL 27.8435 mL
5 mM 0.5569 mL 2.7844 mL 5.5687 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7844 mL 13.9218 mL 27.8435 mL 69.6088 mL
5 mM 0.5569 mL 2.7844 mL 5.5687 mL 13.9218 mL
10 mM 0.2784 mL 1.3922 mL 2.7844 mL 6.9609 mL
15 mM 0.1856 mL 0.9281 mL 1.8562 mL 4.6406 mL
20 mM 0.1392 mL 0.6961 mL 1.3922 mL 3.4804 mL
25 mM 0.1114 mL 0.5569 mL 1.1137 mL 2.7844 mL
30 mM 0.0928 mL 0.4641 mL 0.9281 mL 2.3203 mL
40 mM 0.0696 mL 0.3480 mL 0.6961 mL 1.7402 mL
50 mM 0.0557 mL 0.2784 mL 0.5569 mL 1.3922 mL
60 mM 0.0464 mL 0.2320 mL 0.4641 mL 1.1601 mL
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IDO-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO-IN-32070018-30-1Indoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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