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isomerases

" in MedChemExpress (MCE) Product Catalog:

74

Inhibitors & Agonists

1

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2

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2

Biochemical Assay Reagents

6

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15

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114086

    PDI Cardiovascular Disease
    ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo .
    ML359
  • HY-148077

    Bacterial Fungal Infection
    Phosphoglycolohydroxamic acid is a potent aldolase and triose-phosphate isomerase inhibitor. Phosphoglycolohydroxamic acid can be used in the research of antibacterial and antifungal area .
    Phosphoglycolohydroxamic acid
  • HY-P4202

    Suc-AEPF-pNA

    Biochemical Assay Reagents Others
    Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .
    Suc-Ala-Glu-Pro-Phe-pNA
  • HY-W011184

    Endogenous Metabolite Metabolic Disease
    6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite .
    6-Phosphogluconic acid trisodium
  • HY-113407A

    Endogenous Metabolite Metabolic Disease
    D-Fructose-6-phosphate disodium is an endogenous metabolite. D-Fructose-6-phosphate can be converted into D-glucose 6-phosphate (HY-112537) under the action of phosphoglucose isomerase. D-Fructose-6-phosphate disodium is a sugar intermediate of the glycolytic pathway .
    D-Fructose-6-phosphate disodium
  • HY-13751

    Sigma Receptor Inflammation/Immunology
    SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .
    SR-31747
  • HY-124890

    Others Metabolic Disease
    Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .
    Thr101
  • HY-P4202A

    Suc-AEPF-pNA TFA

    Biochemical Assay Reagents Others
    Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .
    Suc-Ala-Glu-Pro-Phe-pNA TFA
  • HY-113514

    Endogenous Metabolite Metabolic Disease
    6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite .
    6-Phosphogluconic acid
  • HY-13751A

    Sigma Receptor Inflammation/Immunology
    SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase .
    SR-31747 free base
  • HY-P3480

    Fluorescent Dye Others
    H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins .
    H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA
  • HY-138802
    ML089
    1 Publications Verification

    Others Metabolic Disease
    ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC50 of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia .
    ML089
  • HY-130588A

    GSAO TFA

    Mitochondrial Metabolism Cancer
    Glutathione arsenoxide (GSAO) TFA is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide TFA targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide TFA causes cell proliferation arrest and cell death. Glutathione arsenoxide TFA can be used to identify cell-surface proteins, such as Protein disulphide isomerase .
    Glutathione arsenoxide TFA
  • HY-100430

    Apoptosis PDI Cancer
    CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .
    CCF642
  • HY-107420
    AY 9944
    3 Publications Verification

    Others Metabolic Disease
    AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol .
    AY 9944
  • HY-122895
    E64FC26
    2 Publications Verification

    Apoptosis PDI Cancer
    E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity .
    E64FC26
  • HY-E70022

    Others Others
    D-Mannose isomerase (PsMaSeAF) is a carbohydrate isomerase catalyzing the reversible isomerization of d-mannose to d-fructose. D-Mannose isomerase (PsMaSeAF) belongs to the N-acylglucosamine 2-epimerase (AGE) superfamily along with AGE, cellobiose 2-epimerase (CE), and aldose-ketose isomerase (AKI) .
    D-Mannose isomerase (PsMaSeAF)
  • HY-E70308

    Endogenous Metabolite Others
    Glucose isomerase is a glucose isomerase that catalyzes the reversible isomerization of D-glucose and D-xylose into D-fructose and D-xylulose, respectively. Glucose isomerase is thermally stable and can be used to produce fructose syrup at high temperatures above 90°C. Glucose isomerase is widely distributed in prokaryotes .
    Glucose isomerase
  • HY-E70120

    Fungal Infection
    Phosphomannose isomerase is the first enzyme involved in the biosynthesis pathway of GDP-Man. Phosphomannose isomerase catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P). Phosphomannose isomerase is important for cell wall synthesis and protein glycosylation. Phosphomannose isomerase is a potent antifungal target to curb the threats posed by A. flavus .
    Phosphomannose isomerase
  • HY-P2931

    TPI

    Endogenous Metabolite Others Cancer
    Triosephosphate isomerase (TPI) is a glycolytic enzyme. Triosephosphate isomerase fast interconverts dihydroxyacetone phosphate and D: -glyceraldehyde-3-phosphate, its catalytic site is at the dimer interface .
    Triosephosphate isomerase
  • HY-P2918

    GPI; Phosphoglucose Isomerase

    Endogenous Metabolite Metabolic Disease Cancer
    Phosphoglucose Isomerase, Rabbit muscle (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .
    Phosphoglucose Isomerase, Rabbit muscle
  • HY-P2918A

    Endogenous Metabolite Metabolic Disease
    Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .
    Phosphoglucose isomerase, bacillus stearothermophilus
  • HY-P2918B

    Endogenous Metabolite Metabolic Disease
    Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .
    Phosphoglucose isomerase, Baker's Yeast
  • HY-122895A

    Apoptosis PDI Cancer
    (E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity .
    (E/Z)-E64FC26
  • HY-111117
    3-Methyltoxoflavin
    1 Publications Verification

    PDI Cancer
    3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM.
    3-Methyltoxoflavin
  • HY-P4359

    PIN1 Others
    Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .
    Suc-AEPF-AMC
  • HY-P2930

    Biochemical Assay Reagents Others
    Peptidylprolyl isomerase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Peptidylprolyl isomerase
  • HY-P2927

    Biochemical Assay Reagents Others
    Protein disulfide isomerase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Protein disulfide isomerase
  • HY-W016508

    Others Others
    L-Mannose is a monosaccharide. L-Mannose can be used as the substrate of mannose-6-phosphate isomerase .
    L-Mannose
  • HY-112945
    MLS0315771
    2 Publications Verification

    Others Metabolic Disease
    MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM.
    MLS0315771
  • HY-N0537
    Xylose
    3 Publications Verification

    D-(+)-Xylose; (+)-Xylose; Wood sugar

    Endogenous Metabolite Others
    D-(+)-xylose (Xylose) is a natural compound that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of xylose.
    Xylose
  • HY-N7386A

    Endogenous Metabolite Metabolic Disease
    D-Erythrose 4-phosphate sodium is a phosphate sodium of the simple sugar Erythrose. Erythritol is actually converted into D-Erythrose 4-phosphate that involves three isomerases .
    D-Erythrose 4-phosphate sodium
  • HY-113317

    Endogenous Metabolite Cardiovascular Disease
    L-Xylulose is an endogenous metabolite present in Blood, Cerebrospinal_Fluid and Urine that can be used for the research of Ribose 5 Phosphate Isomerase Deficiency .
    L-Xylulose
  • HY-P2886

    Phosphoriboisomerase

    Biochemical Assay Reagents Others
    Ribose-5-phosphate isomerase (Phosphoriboisomerase) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Ribose-5-phosphate isomerase
  • HY-124866

    PDI Neurological Disease
    PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability .
    PDI-IN-3
  • HY-N3007
    Naringenin chalcone
    2 Publications Verification

    Others Inflammation/Immunology
    Naringenin chalcone is an intermediate in flavonol biosynthesis and is spontaneously metabolized into naringenin (NAR) by chalcone isomerase. Naringenin chalcone is an orally active anti-inflammatory and antiallergic agent .
    Naringenin chalcone
  • HY-W040141

    Endogenous Metabolite Metabolic Disease
    L-Arabinitol is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean, and is also associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency.
    L-Arabinitol
  • HY-128592

    PIN1 Cancer
    TAB29 is a potent inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with an IC50 of 874 nM, possesses therapeutic potential for human cancers .
    TAB29
  • HY-113375

    D-Ribose

    Endogenous Metabolite Cardiovascular Disease
    D-Ribofuranose (D-Ribose) is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Ribose 5 Phosphate Isomerase Deficiency and Medium Chain Acyl Co A Dehydrogenase Deficiency .
    D-Ribofuranose
  • HY-E70440

    Biochemical Assay Reagents Others
    L-Arabinose isomerase is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
    L-Arabinose isomerase
  • HY-E70430

    Biochemical Assay Reagents Others
    N-Acylhexosamine oxidase is an isomerase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
    N-Acylhexosamine oxidase
  • HY-110172

    PDI Cancer
    PDI-IN-1 (Compound P1) is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC50 of 1.7 μM. PDI-IN-1 has anti-cancer activity.
    PDI-IN-1
  • HY-N0537R

    Endogenous Metabolite Others
    Xylose (Standard) is the analytical standard of Xylose. This product is intended for research and analytical applications. D-(+)-xylose (Xylose) is a natural compound that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of xylose.
    Xylose (Standard)
  • HY-P2734

    Biochemical Assay Reagents Others
    Phosphopentomutase (EC 5.4.2.7) is an isomerase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
    Phosphorylase a, rabbit muscle
  • HY-126825

    Others Metabolic Disease
    NE21650 potently inhibits farnesyl diphosphate (FPP) synthase. NE21650 is a weak inhibitor of isopentenyl diphosphate (IPP) isomerase. NE21650 is a potent inhibitor of protein prenylation in osteoclasts and macrophages and bone resorption in vitro .
    NE21650
  • HY-167805

    Biochemical Assay Reagents
    D-Glucose 6-phosphate potassium is a biologically active compound that has the activity of being a substrate for glucose-6-phosphate isomerase. D-Glucose 6-phosphate potassium can participate in the sugar metabolism process and promote the production and utilization of energy in cells.
    D-Glucose 6-phosphate potassium
  • HY-B1228
    Ribostamycin sulfate
    1 Publications Verification

    Vistamycin sulfate

    Bacterial Antibiotic PDI Infection
    Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies
    Ribostamycin sulfate
  • HY-107193
    Bacitracin
    1 Publications Verification

    Bacterial Antibiotic PDI Infection Cancer
    Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .
    Bacitracin
  • HY-139361
    Sulfopin
    2 Publications Verification

    PIN1-3

    PIN1 Cancer
    Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors .
    Sulfopin
  • HY-116716

    MicroRNA Cancer
    PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .
    PIN1 inhibitor API-1

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