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NE21650 potently inhibits farnesyl diphosphate (FPP) synthase. NE21650 is a weak inhibitor of isopentenyl diphosphate (IPP) isomerase. NE21650 is a potent inhibitor of protein prenylation in osteoclasts and macrophages and bone resorption in vitro.

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NE21650 Chemical Structure

NE21650 Chemical Structure

CAS No. : 427899-21-6

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Description

NE21650 potently inhibits farnesyl diphosphate (FPP) synthase. NE21650 is a weak inhibitor of isopentenyl diphosphate (IPP) isomerase. NE21650 is a potent inhibitor of protein prenylation in osteoclasts and macrophages and bone resorption in vitro[1].

Molecular Weight

297.14

Formula

C8H13NO7P2
CAS No.
SMILES

OC(P(O)(O)=O)(P(O)(O)=O)CC1=CC=CC=C1N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NE21650 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NE21650427899-21-6NE 21650NE-21650Othersfarnesyl diphosphateFPPisopentenyl diphosphateIPPprotein prenylationosteoclastsmacrophagesbone resorptionInhibitorinhibitorinhibit

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