2. Apoptosis Immunology/Inflammation
  3. Caspase Apoptosis Cyclophilin
  4. C105SR

C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model.

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C105SR Chemical Structure

C105SR Chemical Structure

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C105SR Related Antibodies

Top Publications Citing Use of Products

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

  • Biological Activity

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Description

C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model[1].

IC50 & Target[1]

Caspase 3

 

Caspase-7

 

Cyclophilin D

5 nM (IC50)

In Vitro

C105SR (0.5/1/5/10/50/100 μM) inhibit CypD PPIase activity in Mitochondria[1].
C105SR (1μM, 4 h for hypoxia (1% O2) plus 1 h for reoxygenation (21% O2)) prevent mPTP opening [1].
C105SR (0.5/1/5/10/50/100 μM, 4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)) reducing hypoxia/reoxygenation-induced cell death in AML-12 cell[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C105SR Related Antibodies

Cell Viability Assay[1]

Cell Line: AML-12 cell
Concentration: 0.5/1/10/50/100 μM
Incubation Time: 4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)
Result: Reduced LDH release and increased cell viability by approximatively 75% at 0.5μM.
In Vivo

C105SR (50 mg/kg, Subcutaneous injection (s.c.), 24 h before ischaemia–reperfusion injury (IRI) surgical procedure, single dose) has protective properties in hepatic IRI model [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hepatic IRI model [1]
Dosage: 50 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Protected mouse livers against the effects of ischaemia and reperfusion.
Molecular Weight

633.60

Formula

C32H33BrN4O3S
SMILES

O=C([C@@H](NC(NCC1=CC2=C(NCCC2)C=C1)=O)C3=CC(Br)=CC=C3OC)N4[C@@H](C5=C6C(C=CS6)=CC=C5)CCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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C105SR Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C105SRCaspaseApoptosisCyclophilincyclophilin D inhibitorhepatocyte cell lineAML-12ischaemia-reperfusion injuryhypoxia and reoxygenationInhibitorinhibitorinhibit

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