2. Apoptosis Immunology/Inflammation
  3. Caspase Apoptosis Cyclophilin
  4. C105SR

C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model.

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C105SR Chemical Structure

C105SR Chemical Structure

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Based on 1 publication(s) in Google Scholar

C105SR Related Antibodies

Top Publications Citing Use of Products

View All Caspase Isoform Specific Products:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

View All Cyclophilin Isoform Specific Products:

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Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

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  • Purity & Documentation

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Description

C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model[1].

IC50 & Target[1]

Caspase 3

 

Caspase-7

 

Cyclophilin D

5 nM (IC50)

In Vitro

C105SR (0.5/1/5/10/50/100 μM) inhibit CypD PPIase activity in Mitochondria[1].
C105SR (1μM, 4 h for hypoxia (1% O2) plus 1 h for reoxygenation (21% O2)) prevent mPTP opening [1].
C105SR (0.5/1/5/10/50/100 μM, 4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)) reducing hypoxia/reoxygenation-induced cell death in AML-12 cell[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C105SR Related Antibodies

Cell Viability Assay[1]

Cell Line: AML-12 cell
Concentration: 0.5/1/10/50/100 μM
Incubation Time: 4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)
Result: Reduced LDH release and increased cell viability by approximatively 75% at 0.5μM.
In Vivo

C105SR (50 mg/kg, Subcutaneous injection (s.c.), 24 h before ischaemia–reperfusion injury (IRI) surgical procedure, single dose) has protective properties in hepatic IRI model [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hepatic IRI model [1]
Dosage: 50 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Protected mouse livers against the effects of ischaemia and reperfusion.
Molecular Weight

633.60

Formula

C32H33BrN4O3S
Appearance

Solid

Color

White to light yellow

SMILES

O=C([C@@H](NC(NCC1=CC2=C(NCCC2)C=C1)=O)C3=CC(Br)=CC=C3OC)N4[C@@H](C5=C6C(C=CS6)=CC=C5)CCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (394.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5783 mL 7.8914 mL 15.7828 mL
5 mM 0.3157 mL 1.5783 mL 3.1566 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5783 mL 7.8914 mL 15.7828 mL 39.4571 mL
5 mM 0.3157 mL 1.5783 mL 3.1566 mL 7.8914 mL
10 mM 0.1578 mL 0.7891 mL 1.5783 mL 3.9457 mL
15 mM 0.1052 mL 0.5261 mL 1.0522 mL 2.6305 mL
20 mM 0.0789 mL 0.3946 mL 0.7891 mL 1.9729 mL
25 mM 0.0631 mL 0.3157 mL 0.6313 mL 1.5783 mL
30 mM 0.0526 mL 0.2630 mL 0.5261 mL 1.3152 mL
40 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9864 mL
50 mM 0.0316 mL 0.1578 mL 0.3157 mL 0.7891 mL
60 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6576 mL
80 mM 0.0197 mL 0.0986 mL 0.1973 mL 0.4932 mL
100 mM 0.0158 mL 0.0789 mL 0.1578 mL 0.3946 mL
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C105SR Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C105SRCaspaseApoptosisCyclophilincyclophilin D inhibitorhepatocyte cell lineAML-12ischaemia-reperfusion injuryhypoxia and reoxygenationInhibitorinhibitorinhibit

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