2. Anti-infection Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Bacterial Antibiotic PDI
  4. Ribostamycin sulfate

Ribostamycin sulfate  (Synonyms: Vistamycin sulfate)

Cat. No.: HY-B1228 Purity: 99.84%
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Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies.

For research use only. We do not sell to patients.

Ribostamycin sulfate Chemical Structure

Ribostamycin sulfate Chemical Structure

CAS No. : 53797-35-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Ribostamycin sulfate:

Ribostamycin sulfate Related Antibodies

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Description

Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies

In Vitro

Ribostamycin is as an intermediate in the biosynthesis of neomycin[1].
Ribostamycin inhibited the chaperone activity of protein disulfide isomerase (PDI), but it did not inhibit the isomerase activity[3].
Ribostamycin is effective against both gram-positive and gram-negative cocci and bacilli including drug-resistant strains. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ribostamycin sulfate Related Antibodies
Molecular Weight

552.55

Formula

C17H36N4O14S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(O)=O.O[C@@H]([C@H](O)[C@@H](CN)O1)[C@@H](N)[C@@]1([H])O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@@]2([H])O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
Structure Classification
Initial Source

Streptomyces ribosidicus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 130 mg/mL (235.27 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8098 mL 9.0490 mL 18.0979 mL
5 mM 0.3620 mL 1.8098 mL 3.6196 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (90.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8098 mL 9.0490 mL 18.0979 mL 45.2448 mL
5 mM 0.3620 mL 1.8098 mL 3.6196 mL 9.0490 mL
10 mM 0.1810 mL 0.9049 mL 1.8098 mL 4.5245 mL
15 mM 0.1207 mL 0.6033 mL 1.2065 mL 3.0163 mL
20 mM 0.0905 mL 0.4524 mL 0.9049 mL 2.2622 mL
25 mM 0.0724 mL 0.3620 mL 0.7239 mL 1.8098 mL
30 mM 0.0603 mL 0.3016 mL 0.6033 mL 1.5082 mL
40 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1311 mL
50 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9049 mL
60 mM 0.0302 mL 0.1508 mL 0.3016 mL 0.7541 mL
80 mM 0.0226 mL 0.1131 mL 0.2262 mL 0.5656 mL
100 mM 0.0181 mL 0.0905 mL 0.1810 mL 0.4524 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ribostamycin sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ribostamycin53797-35-6VistamycinBacterialAntibioticPDIProtein Disulfide IsomerasesInhibitorinhibitorinhibit

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