2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. PDI
  4. PDI-IN-3

PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability.

For research use only. We do not sell to patients.

PDI-IN-3 Chemical Structure

PDI-IN-3 Chemical Structure

CAS No. : 922507-80-0

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1 mg USD 240 In-stock
5 mg USD 500 In-stock
10 mg USD 755 In-stock
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Based on 1 publication(s) in Google Scholar

PDI-IN-3 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability[1].

In Vitro

PDI-IN-3 (compound 16F16) (0.1, 1, 10, 100 µM; 48 h) inhibits cell viability in htt-Q25 and htt-Q103 cells[1].
PDI-IN-3 (1, 2, 3, 4, 10 µM) suppress htt-N90Q73-induced toxicity in brain slice MSNs (medium spiny neurons)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDI-IN-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: htt-Q25, htt-Q103 cells
Concentration: 0.1, 1, 10, 100 µM
Incubation Time: 48 h
Result: Inhibited cell growth in a dose-dependent manner.
Molecular Weight

320.77

Formula

C16H17ClN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(C)C2=C(CCN1C(CCl)=O)C3=C(C=CC=C3)N2)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12 mg/mL (37.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1175 mL 15.5875 mL 31.1750 mL
5 mM 0.6235 mL 3.1175 mL 6.2350 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1175 mL 15.5875 mL 31.1750 mL 77.9375 mL
5 mM 0.6235 mL 3.1175 mL 6.2350 mL 15.5875 mL
10 mM 0.3117 mL 1.5587 mL 3.1175 mL 7.7937 mL
15 mM 0.2078 mL 1.0392 mL 2.0783 mL 5.1958 mL
20 mM 0.1559 mL 0.7794 mL 1.5587 mL 3.8969 mL
25 mM 0.1247 mL 0.6235 mL 1.2470 mL 3.1175 mL
30 mM 0.1039 mL 0.5196 mL 1.0392 mL 2.5979 mL
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PDI-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDI-IN-3922507-80-0PDIProtein Disulfide Isomeraseshtt-Q25htt-Q103 cellshtt-N90Q73Inhibitorinhibitorinhibit

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