Search Result
Results for "
narrow
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B1358
-
|
Bacterial
Antibiotic
|
Infection
|
Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic, has similar effects to erythromycin, which has a good effect on gram-positive coccus, mainly used to inhibit the synthesis of bacterial cell protein .
|
-
-
- HY-141715
-
|
Antibiotic
|
Infection
|
BRD-8000.3, as a specific EfpA inhibitor, is a narrow-spectrum, bactericidal antimycobacterial agent with good wild-type activity. BRD-8000.3 can be used for the research of tuberculosis .
|
-
-
- HY-108909
-
|
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
|
Chymopapain is a non-specific proteo-glycanase derived from the papaya plant. Chymopapain directly into the intervertebral disc caused disc narrowing due to dissolution of the extruded material. Chymopapain has the potential for the research of herniated lumbar discs .
|
-
-
- HY-D1040
-
Cyanine 5.5 carboxylic acid
|
Fluorescent Dye
|
Others
|
CY5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH shows narrow absorption spectrum, and high sensitivity and stability .
|
-
-
- HY-162926
-
|
Bacterial
|
Infection
|
Antituberculosis agent-12 (compound 3408) is a narrow-spectrum antituberculosis prodrug phosphate that has the ability to inhibit drug-resistant tuberculosis infection .
|
-
-
- HY-W110781
-
|
DNA Stain
|
Others
|
Basic Blue 20 is a very convenient red-emitting DNA stains. Basic Blue 20 has relatively narrow excitation and emission spectra, with peaks at 633 and 677 nm, respectively. Basic Blue 20 also has a very high resistance to photobleaching .
|
-
-
- HY-18324
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REP-3123
|
Antibiotic
|
Inflammation/Immunology
|
CRS3123 is a potent and orally active narrow-spectrum antibiotic. CRS3123 inhibits bacterial methionyl-tRNA synthetase. CRS3123 has potent activity against Clostridium difficile (C. difficile) and aerobic Gram-positive bacteria but little activity against Gram-negative bacteria, including anaerobes. CRS3123 has the potential for the research of C. difficile infections .
|
-
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- HY-B0925S
-
-
-
- HY-160930
-
|
p38 MAPK
Src
Syk
|
Inflammation/Immunology
|
TOP1288 is a narrow spectrum kinase inhibitor for P38α, Src and Syk kinase, with IC50 of 116nM, 24nM and 659nM, respectively. TOP1288 inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts .
|
-
-
- HY-D1040A
-
Cyanine 5.5 carboxylic acid chloride
|
Fluorescent Dye
|
Others
|
CY5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH chloride shows narrow absorption spectrum, and high sensitivity and stability .
|
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- HY-B0977
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Dicloxacillin sodium salt monohydrate
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus .
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-
-
- HY-121544A
-
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
Histamine Receptor
|
Infection
|
Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis .
|
-
-
- HY-121544
-
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
Histamine Receptor
|
Infection
|
Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis .
|
-
-
- HY-B1358R
-
|
Bacterial
Antibiotic
|
Infection
|
Lincomycin (hydrochloride monohydrate) (Standard) is the analytical standard of Lincomycin (hydrochloride monohydrate). This product is intended for research and analytical applications. Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic, has similar effects to erythromycin, which has a good effect on gram-positive coccus, mainly used to inhibit the synthesis of bacterial cell protein .
|
-
-
- HY-151437
-
|
Fungal
|
Infection
|
Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51. Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation .
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-
- HY-157808
-
|
Bacterial
|
Infection
|
Antibacterial agent 185 (compound IP-01) is a potent antibacterial agent. Antibacterial agent 185 inhibits filamentous temperature-sensitive mutant Z (FtsZ) polymerization and bundling by increasing GTP hydrolysis. Antibacterial agent 185 inhibits Streptococcus pneumoniae and shows narrow-spectrum activity .
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-
- HY-17580
-
Fidaxomicin
Maximum Cited Publications
6 Publications Verification
OPT-80; PAR-101
|
DNA/RNA Synthesis
Bacterial
Apoptosis
Antibiotic
|
Infection
|
Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .
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-
-
- HY-B0977R
-
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Dicloxacillin (Sodium hydrate) (Standard) is the analytical standard of Dicloxacillin (Sodium hydrate). This product is intended for research and analytical applications. Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus .
|
-
-
- HY-121544AR
-
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
Histamine Receptor
|
Infection
|
Methicillin (sodium hydrate) (Standard) is the analytical standard of Methicillin (sodium hydrate). This product is intended for research and analytical applications. Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis .
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-
-
- HY-13858A
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P-005672 hydrochloride
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne
.
|
-
-
- HY-16770
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P-005672
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne .
|
-
-
- HY-D2194
-
|
Fluorescent Dye
|
Others
|
AgAuSe-COOH (1000 nm) is a fluorescent quantum dot that emits fluorescence in the near-infrared II region, with an emission peak reaching 1000 nm. AgAuSe-COOH (1000 nm) has the advantages of narrow band gap, large Stokes shift, and good photostability. AgAuSe-COOH (1000 nm) can bind proteins, antibodies, peptides, PEG, etc., and can be widely used in the field of biological imaging.
|
-
-
- HY-17580S
-
|
Isotope-Labeled Compounds
Bacterial
Apoptosis
Antibiotic
|
Infection
|
Fidaxomicin-d7 (OPT-80-D7) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora[1][2].
|
-
-
- HY-150781
-
|
EGFR
|
Cancer
|
EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma . EGFR-IN-71 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-W250168B
-
Polyethylene glycol oleyl ether, average Mn~357; Polyethylene glycol monooleyl ether, n~2
|
Biochemical Assay Reagents
|
Others
|
Polyoxyethylene(2) oleyl ether (Polyethylene glycol oleyl ether, average Mn~357; Polyethylene glycol monooleyl ether, n~2) is a nonionic surfactant. Polyoxyethylene(2) oleyl ether promoting the formation of spherical-shaped nanosystems with a narrow size distribution. Polyoxyethylene(2) oleyl ether can be used for the delivery of several active compounds .
|
-
-
- HY-120595
-
RV568
|
p38 MAPK
Src
|
Inflammation/Immunology
|
JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma .
|
-
-
- HY-157232
-
|
Biochemical Assay Reagents
|
Others
|
AC Antibody purification resin 2 is based on spherical, highly cross-linked agarose beads with a narrow size distribution and high mechanical stability. Used for the separation and purification of complex antibodies such as monoclonal antibody, double antibody, multi-antibody and Fc fusion protein .
Substrate: highly crosslinked agarose microspheres; Particle size: 65μm; Ligand: alkali-resistant recombinant Protein A; ADC purified resin.
|
-
-
- HY-D2264
-
|
Fluorescent Dye
|
Others
|
Caffeine orange (Compound 1) is an aqueous-phase fluorescence turn-on sensor for caffeine that is highly selective to caffeine. Caffeine orange makes caffeinated coffee appear orange when exposed to 532 nM of green excitation light. Caffeine orange has excellent photophysical properties such as high extinction coefficient, high light stability and narrow emission bandwidth, which can be used in the research of caffeine detection devices 。
|
-
-
- HY-17580R
-
|
DNA/RNA Synthesis
Bacterial
Apoptosis
Antibiotic
|
Infection
|
Fidaxomicin (Standard) is the analytical standard of Fidaxomicin. This product is intended for research and analytical applications. Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .
|
-
-
- HY-13858AR
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
Sarecycline (hydrochloride) (Standard) is the analytical standard of Sarecycline (hydrochloride). This product is intended for research and analytical applications. Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .
|
-
-
- HY-A0083C
-
Acetyl-β-methylcholine iodide
|
mAChR
|
Cardiovascular Disease
|
Methacholine iodide is a potent muscarinic-3 (M3) agonist. Methacholine iodide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine iodide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine iodide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .
|
-
-
- HY-A0083
-
Acetyl-β-methylcholine chloride
|
mAChR
|
Others
|
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .
|
-
-
- HY-A0083B
-
Acetyl-β-methylcholine bromide
|
mAChR
|
Cardiovascular Disease
|
Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .
|
-
-
- HY-139337
-
|
Fluorescent Dye
|
Metabolic Disease
|
SMCy5.5 is an SMCy dye used for lipid droplet labeling with a very high two-photon absorption cross-section. SMCy, unlike the well-known lipid droplet marker Nile Red, has narrow absorption and emission bands in visible light, allowing for multicolor imaging. SMCy is shown to be compatible with fixation, producing high-quality 3D images of lipid droplets in cells and tissues. The high brightness of SMCy5.5 enables efficient tracking and imaging of lipid droplet exchange between adipocytes .
|
-
-
- HY-A0083R
-
|
mAChR
|
Others
|
Methacholine (chloride) (Standard) is the analytical standard of Methacholine (chloride). This product is intended for research and analytical applications. Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .
|
-
-
- HY-125387
-
|
Src
|
Inflammation/Immunology
|
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .
|
-
-
- HY-115440
-
REP-3123 dihydrochloride
|
Bacterial
Antibiotic
|
Infection
|
CRS3123 (REP-3123) dihydrochloride, a fully synthetic antibacterial agent, potently inhibits methionyl-tRNA synthetase (MetRS) of Clostridioides difficile, inhibiting Clostridioides difficile toxin production and spore formation. CRS3123 dihydrochloride is an oral agent for the research of Clostridioides difficile infection (CDI) .
|
-
-
-
HY-L052
-
|
1,470 compounds
|
COVID-19 poses a serious threat to people's health, and it is urgent to develop drugs to treat COVID-19 quickly. The screening of anti-COVID-19 drugs by using the clinical and approved compounds can greatly shorten the research and development cycle. In addition, the virtual screening technology can effectively narrow the scope of screening and improve the screening efficiency in the pre-screening of new drugs.
Taking advantage of our virtual screening, we conduct virtual screening of approved compound library and clinical compound library based on the 3CL protease (PDB ID: 6LU7), Spike Glycoprotein (PDB ID: 6VSB), NSP15 (PDB ID: 6VWW), RDRP, PLPro and ACE2 (Angiotensin Converting Enzyme 2) structure. We design a unique collection of 1,470 compounds which may have anti-COVID-19 activity. Anti-COVID-19 Compound Library will be a powerful tool for screening new anti-COVID-19 activity drugs.
|
Cat. No. |
Product Name |
Type |
-
- HY-D1040
-
Cyanine 5.5 carboxylic acid
|
Fluorescent Dyes/Probes
|
CY5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH shows narrow absorption spectrum, and high sensitivity and stability .
|
-
- HY-D2264
-
|
Fluorescent Dyes/Probes
|
Caffeine orange (Compound 1) is an aqueous-phase fluorescence turn-on sensor for caffeine that is highly selective to caffeine. Caffeine orange makes caffeinated coffee appear orange when exposed to 532 nM of green excitation light. Caffeine orange has excellent photophysical properties such as high extinction coefficient, high light stability and narrow emission bandwidth, which can be used in the research of caffeine detection devices 。
|
-
- HY-139337
-
|
Fluorescent Dyes/Probes
|
SMCy5.5 is an SMCy dye used for lipid droplet labeling with a very high two-photon absorption cross-section. SMCy, unlike the well-known lipid droplet marker Nile Red, has narrow absorption and emission bands in visible light, allowing for multicolor imaging. SMCy is shown to be compatible with fixation, producing high-quality 3D images of lipid droplets in cells and tissues. The high brightness of SMCy5.5 enables efficient tracking and imaging of lipid droplet exchange between adipocytes .
|
-
- HY-D1040A
-
Cyanine 5.5 carboxylic acid chloride
|
Fluorescent Dyes/Probes
|
CY5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH chloride shows narrow absorption spectrum, and high sensitivity and stability .
|
-
- HY-D2194
-
|
Fluorescent Dyes/Probes
|
AgAuSe-COOH (1000 nm) is a fluorescent quantum dot that emits fluorescence in the near-infrared II region, with an emission peak reaching 1000 nm. AgAuSe-COOH (1000 nm) has the advantages of narrow band gap, large Stokes shift, and good photostability. AgAuSe-COOH (1000 nm) can bind proteins, antibodies, peptides, PEG, etc., and can be widely used in the field of biological imaging.
|
Cat. No. |
Product Name |
Type |
-
- HY-W250168B
-
Polyethylene glycol oleyl ether, average Mn~357; Polyethylene glycol monooleyl ether, n~2
|
Surfactants
|
Polyoxyethylene(2) oleyl ether (Polyethylene glycol oleyl ether, average Mn~357; Polyethylene glycol monooleyl ether, n~2) is a nonionic surfactant. Polyoxyethylene(2) oleyl ether promoting the formation of spherical-shaped nanosystems with a narrow size distribution. Polyoxyethylene(2) oleyl ether can be used for the delivery of several active compounds .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-17580S
-
|
Fidaxomicin-d7 (OPT-80-D7) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora[1][2].
|
-
-
- HY-B0925S
-
|
Oxacillin- 13C6 (sodium) is the 13C6 labeled Oxacillin (sodium). Oxacillin sodium salt is a narrow-spectrum β-lactam antibiotic of the penicillin class.
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-139337
-
|
|
Alkynes
|
SMCy5.5 is an SMCy dye used for lipid droplet labeling with a very high two-photon absorption cross-section. SMCy, unlike the well-known lipid droplet marker Nile Red, has narrow absorption and emission bands in visible light, allowing for multicolor imaging. SMCy is shown to be compatible with fixation, producing high-quality 3D images of lipid droplets in cells and tissues. The high brightness of SMCy5.5 enables efficient tracking and imaging of lipid droplet exchange between adipocytes .
|
-
- HY-150781
-
|
|
Alkynes
|
EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma . EGFR-IN-71 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-125387
-
|
|
Alkynes
|
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .
|
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