2. Anti-infection
  3. Bacterial Antibiotic
  4. Dicloxacillin Sodium hydrate

Dicloxacillin Sodium hydrate  (Synonyms: Dicloxacillin sodium salt monohydrate)

Cat. No.: HY-B0977 Purity: 98.94%
COA Handling Instructions

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Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus.

For research use only. We do not sell to patients.

Dicloxacillin Sodium hydrate Chemical Structure

Dicloxacillin Sodium hydrate Chemical Structure

CAS No. : 13412-64-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 28 In-stock
Solution
10 mM * 1 mL in Water USD 28 In-stock
Solid
5 mg USD 25 In-stock
10 mg USD 35 In-stock
50 mg USD 60 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Dicloxacillin Sodium hydrate:

Dicloxacillin Sodium hydrate Related Antibodies

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2 Publications Citing Use of MCE Dicloxacillin Sodium hydrate

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  • Biological Activity

  • Purity & Documentation

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Description

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus[1][2][3].

IC50 & Target

β-lactam

 

In Vitro

Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dicloxacillin Sodium hydrate Related Antibodies

Cell Viability Assay[3]

Cell Line: Strains ATCC 25923 and E19977.
Concentration: 0-500 mg/L.
Incubation Time: Up to 24 h.
Result: Exhibited EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively.
In Vivo

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)[4].
Dosage: 125 mg/kg.
Administration: IV injection, single doses.
Result: All the mice survived.
Clinical Trial
Molecular Weight

510.32

Formula

C19H18Cl2N3NaO6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])[C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)N1C2=O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (48.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9596 mL 9.7978 mL 19.5955 mL
5 mM 0.3919 mL 1.9596 mL 3.9191 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (48.99 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.94%

COA (263 KB) HNMR (166 KB) LCMS (276 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9596 mL 9.7978 mL 19.5955 mL 48.9889 mL
5 mM 0.3919 mL 1.9596 mL 3.9191 mL 9.7978 mL
10 mM 0.1960 mL 0.9798 mL 1.9596 mL 4.8989 mL
15 mM 0.1306 mL 0.6532 mL 1.3064 mL 3.2659 mL
20 mM 0.0980 mL 0.4899 mL 0.9798 mL 2.4494 mL
25 mM 0.0784 mL 0.3919 mL 0.7838 mL 1.9596 mL
30 mM 0.0653 mL 0.3266 mL 0.6532 mL 1.6330 mL
40 mM 0.0490 mL 0.2449 mL 0.4899 mL 1.2247 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dicloxacillin Sodium hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dicloxacillin Sodium13412-64-1Dicloxacillin sodium saltBacterialAntibioticperitonitissepsisInhibitorinhibitorinhibit

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