2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. p38 MAPK Src
  4. JNJ-49095397

JNJ-49095397  (Synonyms: RV568)

Cat. No.: HY-120595 Purity: 99.85%
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JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma.

For research use only. We do not sell to patients.

JNJ-49095397 Chemical Structure

JNJ-49095397 Chemical Structure

CAS No. : 1220626-82-3

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5 mg USD 260 In-stock
10 mg USD 420 In-stock
25 mg USD 840 In-stock
50 mg USD 1350 In-stock
100 mg USD 2160 In-stock
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Based on 1 publication(s) in Google Scholar

JNJ-49095397 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All Src Isoform Specific Products:

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Lck Fyn Blk

  • Biological Activity

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Description

JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma[1].

IC50 & Target[1]

p38α

 

p38γ

 

Haematopoietic Kinase (HCK)

 

In Vitro

JNJ-49095397 (RV568) (1 pg-1 μg/mL; 4 h) inhibits LPS-induced CXCL8 release in PBMCs and d-U937 cells[1].
JNJ-49095397 (1 μg-1 g/mL; 4 h) inhibits TNFα-induced interleukin (IL)-6 and CXCL8 release in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-49095397 Related Antibodies
In Vivo

JNJ-49095397 (RV568) (1-20 μg/mouse; intratracheal; once) shows anti-inflammatory activities in LPS-induced neutrophil accumulation mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonfasted Balb/c mice, LPS-induced neutrophil accumulation model[1]
Dosage: 1, 4 and 20 μg/mouse
Administration: Intratracheal administration, 2, 8 or 12 h prior to LPS inhalation
Result: Prevented the accumulation of neutrophils in the BAL fluid. Significantly inhibited neutrophil accumulation when administered up to 8 h prior to LPS inhalation.
Clinical Trial
Molecular Weight

592.69

Formula

C34H36N6O4
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C(NC1=NC=CC(COC2=C3C=CC=CC3=C(NC(NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5)=O)C=C2)=C1)COC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (168.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6872 mL 8.4361 mL 16.8722 mL
5 mM 0.3374 mL 1.6872 mL 3.3744 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6872 mL 8.4361 mL 16.8722 mL 42.1806 mL
5 mM 0.3374 mL 1.6872 mL 3.3744 mL 8.4361 mL
10 mM 0.1687 mL 0.8436 mL 1.6872 mL 4.2181 mL
15 mM 0.1125 mL 0.5624 mL 1.1248 mL 2.8120 mL
20 mM 0.0844 mL 0.4218 mL 0.8436 mL 2.1090 mL
25 mM 0.0675 mL 0.3374 mL 0.6749 mL 1.6872 mL
30 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4060 mL
40 mM 0.0422 mL 0.2109 mL 0.4218 mL 1.0545 mL
50 mM 0.0337 mL 0.1687 mL 0.3374 mL 0.8436 mL
60 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.7030 mL
80 mM 0.0211 mL 0.1055 mL 0.2109 mL 0.5273 mL
100 mM 0.0169 mL 0.0844 mL 0.1687 mL 0.4218 mL
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JNJ-49095397 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-490953971220626-82-3RV568JNJ49095397JNJ 49095397RV 568RV-568p38 MAPKSrcanti-inflammatoryCOPDchronic obstructive pulmonary disease. AsthmaHCKhaematopoietic kinaseCXCL8neutrophil accumulationInhibitorinhibitorinhibit

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