2. Anti-infection
  3. Antibiotic
  4. CRS3123

CRS3123 is a potent and orally active narrow-spectrum antibiotic. CRS3123 inhibits bacterial methionyl-tRNA synthetase. CRS3123 has potent activity against Clostridium difficile (C. difficile) and aerobic Gram-positive bacteria but little activity against Gram-negative bacteria, including anaerobes. CRS3123 has the potential for the research of C. difficile infections.

For research use only. We do not sell to patients.

CRS3123 Chemical Structure

CRS3123 Chemical Structure

CAS No. : 1013915-71-3

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CRS3123 Related Antibodies

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Description

CRS3123 is a potent and orally active narrow-spectrum antibiotic. CRS3123 inhibits bacterial methionyl-tRNA synthetase. CRS3123 has potent activity against Clostridium difficile (C. difficile) and aerobic Gram-positive bacteria but little activity against Gram-negative bacteria, including anaerobes. CRS3123 has the potential for the research of C. difficile infections[1].

Clinical Trial
Molecular Weight

513.25

Formula

C19H19Br2N3O2S
CAS No.
SMILES

BrC1=C(OCC2)C([C@@H]2NCCCNC3=CC(C(SC=C4)=C4N3)=O)=CC(Br)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (194.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9484 mL 9.7418 mL 19.4837 mL
5 mM 0.3897 mL 1.9484 mL 3.8967 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9484 mL 9.7418 mL 19.4837 mL 48.7092 mL
5 mM 0.3897 mL 1.9484 mL 3.8967 mL 9.7418 mL
10 mM 0.1948 mL 0.9742 mL 1.9484 mL 4.8709 mL
15 mM 0.1299 mL 0.6495 mL 1.2989 mL 3.2473 mL
20 mM 0.0974 mL 0.4871 mL 0.9742 mL 2.4355 mL
25 mM 0.0779 mL 0.3897 mL 0.7793 mL 1.9484 mL
30 mM 0.0649 mL 0.3247 mL 0.6495 mL 1.6236 mL
40 mM 0.0487 mL 0.2435 mL 0.4871 mL 1.2177 mL
50 mM 0.0390 mL 0.1948 mL 0.3897 mL 0.9742 mL
60 mM 0.0325 mL 0.1624 mL 0.3247 mL 0.8118 mL
80 mM 0.0244 mL 0.1218 mL 0.2435 mL 0.6089 mL
100 mM 0.0195 mL 0.0974 mL 0.1948 mL 0.4871 mL
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CRS3123 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRS31231013915-71-3REP-3123CRS 3123CRS-3123REP3123REP 3123Antibiotic(C. difficile)orally activeinfectionsantibioticgut microbiotanarrow spectrumphase 1Inhibitorinhibitorinhibit

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