2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. SIB-1757

SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM.

For research use only. We do not sell to patients.

SIB-1757 Chemical Structure

SIB-1757 Chemical Structure

CAS No. : 31993-01-8

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5 mg USD 110 In-stock
10 mg USD 175 In-stock
25 mg USD 350 In-stock
50 mg USD 550 In-stock
100 mg USD 770 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

SIB-1757 Related Antibodies

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  • Biological Activity

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Description

SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM[1].

IC50 & Target

human mGluR5

0.4 μM (IC50)

In Vitro

SIB-1757 (2 μM) reduces the 3,5-DHPG-induced membrane depolarization of the recorded neuron in striatal cholinergic interneurons[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIB-1757 Related Antibodies
In Vivo

SIB-1757 (20 mg/kg, i.p.) reduces the Acetaminophen (HY-66005) induced increased expression and activity of liver iNOS in mice[2].
SIB-1757 (intraplantar injection of 100 μg, or s.c. injection of 20 mg/kg) reverses spinal nerve ligation-induced thermal hyperalgesia in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

213.24

Formula

C12H11N3O
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

OC1=CC=C(C)N=C1/N=N/C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (58.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6896 mL 23.4478 mL 46.8955 mL
5 mM 0.9379 mL 4.6896 mL 9.3791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6896 mL 23.4478 mL 46.8955 mL 117.2388 mL
5 mM 0.9379 mL 4.6896 mL 9.3791 mL 23.4478 mL
10 mM 0.4690 mL 2.3448 mL 4.6896 mL 11.7239 mL
15 mM 0.3126 mL 1.5632 mL 3.1264 mL 7.8159 mL
20 mM 0.2345 mL 1.1724 mL 2.3448 mL 5.8619 mL
25 mM 0.1876 mL 0.9379 mL 1.8758 mL 4.6896 mL
30 mM 0.1563 mL 0.7816 mL 1.5632 mL 3.9080 mL
40 mM 0.1172 mL 0.5862 mL 1.1724 mL 2.9310 mL
50 mM 0.0938 mL 0.4690 mL 0.9379 mL 2.3448 mL
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SIB-1757 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIB-175731993-01-8SIB1757SIB 1757mGluRMetabotropic glutamate receptorshyperalgesiaglutamateInhibitorinhibitorinhibit

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