2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. SK-7041

SK-7041 is a HDAC inhibitor with the IC50 of 172 nM. SK-7041 induces the hyperacetylation of histones H3 and H4 .SK-7041 inhibits tumor cell growth in vivo and in vitro, induces cell apoptosis, and arrests cell cycle at the G1 phase.

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SK-7041 Chemical Structure

SK-7041 Chemical Structure

CAS No. : 617690-98-9

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SK-7041 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

SK-7041 is a HDAC inhibitor with the IC50 of 172 nM. SK-7041 induces the hyperacetylation of histones H3 and H4 .SK-7041 inhibits tumor cell growth in vivo and in vitro, induces cell apoptosis, and arrests cell cycle at the G1 phase[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.48 μM
Compound: 5a
Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
[PMID: 14667227]
Molecular Weight

339.39

Formula

C19H21N3O3
CAS No.
SMILES

ONC(/C=C/C(C=C1)=CC=C1CNC(C2=CC=C(C=C2)N(C)C)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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SK-7041 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK-7041617690-98-9SK7041SK 7041HDACApoptosisHistone deacetylasesSNU-16 cells,rat intestinal epithelial cellshuman gastric cancer cellsInhibitorinhibitorinhibit

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